Beta-adrenergic stimulation of cAMP and progesterone in rat ovarian tissue

Ratner, Albert; Sanborn, Carolyn R.; Weiss, Gerald K.

doi:10.1152/ajpendo.1980.239.2.e139

Cited by 20 publications

(20 citation statements)

References 17 publications

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“…Progesterone production has been reported to be stimulated by catecholamines (Condon & Black, 1976;Jordan, Chaffrey & Niswender, 1978;Ratner, Sanborn & Weiss, 1980; Adashi & Hseuh, 1981 ;Zsolnai, Varga & Horvath, 1982). In the present study, removal of ovarian adrenergic nerves at Day 3 of the cycle did not alter progesterone concentrations at Day 15, a period when progesterone production is low (Joshi, Watson & Labhsetwar, 1973;Blatchley, Donovan & ter Haar, 1976).…”

supporting

confidence: 46%

Effect of ovarian sympathectomy on follicular development during compensatory ovarian hypertrophy in the guinea-pig

Curry¹,

Lawrence²,

Burden³

1984

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Selective ovarian sympathectomy was achieved by injecting 6-hydroxydopamine into a surgically closed periovarian bursa on Day 3 of the oestrous cycle (Day 1 = day of oestrus). Control ovaries had the periovarian bursa surgically closed and were injected with solvent. On Day 15 of the cycle, serum was collected for progesterone determination and ovaries were processed for morphometric analysis of follicles. In both control and sympathectomized ovaries remaining after unilateral ovariectomy on Day 3, there was an increase in ovarian weight and an increase in healthy preovulatory follicles (greater than 700 microns diam.). Sympathectomy of the ovary remaining after unilateral ovariectomy increased healthy follicles 510-700 microns diameter but decreased the total number of follicles per ovary. In animals bearing both ovaries, unilateral sympathectomy did not affect any of the characteristics measured. Serum progesterone concentrations were unaffected by any of the treatments. These results indicate that adrenergic nerves play a role in follicular dynamics in ovaries undergoing compensatory hypertrophy but are not necessary for compensatory increases in weight and number of preovulatory follicles.

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supporting

confidence: 46%

Effect of ovarian sympathectomy on follicular development during compensatory ovarian hypertrophy in the guinea-pig

Curry¹,

Lawrence²,

Burden³

1984

Reproduction

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“…The role of catecholamins in progesterone production is more controversial. Although catecholamines increase CAMP and progesterone production in luteal tissue in vitro (Harwood et al, 1980;Ratner et al, 1980;Norjavaara et al, 1982), their physiological significance in vivo is unclear. Our studies reveal that the lowest NE synthesis occurs at the time of peak plasma progesterone levels.…”

Section: Discussionmentioning

confidence: 99%

“…It is difficult t o envision a major role for NE in promoting progesterone production at a time when both NE synthesis and content are reduced. Another apparent paradox is that progesterone production during the luteal phase is coupled to 0-adrenergic receptors (Condon and Black, 1976;Jordan et al, 1978;Ratner et al, 1980), which have a higher affinity for epinephrine than NE. Yet, NE is the only intrinsic catecholamine of the ovary and is the final product of the biosynthetic pathway.…”

Section: Discussionmentioning

confidence: 99%

Changes in Ovarian Norepinephrine Synthesis throughout the Follicular and Luteal Phases1

Arbogast

Garris

Rhoades

et al. 1987

Biology of Reproduction

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The aims of this study were to determine norepinephrine (NE) synthesis in follicle-dominated and luteal-dominated ovaries as compared to oviducts, and to correlate NE synthesis with NE content and turnover rates. Rats were injected with pregnant mare's serum gonadotropin (PMSG) on Day 28. Ovaries and oviducts were removed during the follicular (Days 28-30) and luteal (Days 31-40) phases and incubated for 2 h with [3H] tyrosine. Tritiated and endogenous NE were determined by high-performance liquid chromatography. Ovarian NE synthesis from [3H] tyrosine was reduced by more than 50% within 24 h after PMSG injection, with a second 50% reduction on Day 30, concomitant with the endogenous gonadotropin surge. The lowest NE synthesis (15% of control values) was observed in the luteinized ovary on Day 33. Ovarian NE synthesis from [3H] L-dihydroxyphenylalanine (DOPA) was similar in control and PMSG-injected rats on selected days during the follicular and luteal phases. Oviductal NE synthesis decreased after PMSG injection, but was similar to control values during the luteal phase. Ovarian NE content was modestly reduced between Days 30 and 35, whereas oviductal NE content was not altered. After an injection of alpha-methyl-p-tyrosine on Day 33, ovarian and oviductal NE content decreased exponentially over a period of 10 h. The NE turnover rates were similar in control and PMSG-injected rats in both tissues. The following conclusions were reached: Circulating gonadotropins appear to suppress ovarian NE synthesis during the follicular phase. The low NE synthesis by the luteinized ovary is consistent with previous reports that follicles, but not corpora lutea (CL), contain catecholamine elements.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…The primary catecholamines noradrenaline and adrenaline can regulate the synthesis in vitro of cAMP and progesterone by luteal tissue from a variety of species (cow: Condon & Black, 1976;Godkin, Black & Duby, 1977;Milvae, Alila & Hansel, 1983; rat: Harwood, Dufau & Catt, 1979;Ratner, Sanborn & Weiss, 1980;Norjavaara, Selstam & Ahren, 1982;rabbit: Birnbaumer, Yang, Hunzicker-Dunn, Brockaert & Duran, 1976; ewe: Jordan, Caffrey & Niswender, 1978). Noradrenaline and adrenaline can interact with both a-and ß-adrenergic receptors although their stimulatory effects on luteal steroidogenesis are mediated by ß-receptors, since their response can be inhibited by ß-adrenergic antagonists but not by a-adrenergic antagonists (Condon & Black, 1976;Jordan et al, 1978;Harwood, Richert, Dufau & Catt, 1980;Ratner et al, 1980;Norjavaara et al 1982).…”

Section: Introductionmentioning

confidence: 99%

“…Noradrenaline and adrenaline can interact with both a-and ß-adrenergic receptors although their stimulatory effects on luteal steroidogenesis are mediated by ß-receptors, since their response can be inhibited by ß-adrenergic antagonists but not by a-adrenergic antagonists (Condon & Black, 1976;Jordan et al, 1978;Harwood, Richert, Dufau & Catt, 1980;Ratner et al, 1980;Norjavaara et al 1982). In contrast, nothing is known about the catecholamines derived through the alternative catecholamine pathway ( Fig.…”

Section: Introductionmentioning

confidence: 99%

A role for alternative pathway catecholamines in the regulation of steroidogenesis in cow luteal cells

Battista¹,

Condon²

1986

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Summary. Incubation of bovine luteal cells with the alternative pathway catecholamines octopamine, synephrine and deoxyadrenaline at concentrations of 10 \ m=-\ 6 to 10\m=-\3 m enhanced the production of progesterone (P < 0\m=.\05).Tryamine did not alter basal progesterone production (P > 0\m=.\05). Addition of noradrenaline and adrenaline at concentrations of 10 \ m=-\ 4 to 10\m=-\7 m significantly elevated the production of progesterone (P < 0\m=.\05). The steroidogenic response to noradrenaline and adrenaline was greater than that for octopamine, synephrine and deoxyadrenaline (P < 0\m=.\05).Response to both primary (10\m=-\6 m) and alternative (10\m=-\4 m) pathway catecholamines was inhibited by propranolol (10\m=-\5m, P < 0\m=.\05) but not phentolamine (10\m=-\5m, P > 0\m=.\05). These results demonstrate that octopamine, synephrine and deoxyadrenaline can affect steroidogenesis by bovine luteal cells, and their action is mediated by \g=b\-adrenergicreceptors.

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Beta-adrenergic stimulation of cAMP and progesterone in rat ovarian tissue

Cited by 20 publications

References 17 publications

Effect of ovarian sympathectomy on follicular development during compensatory ovarian hypertrophy in the guinea-pig

Effect of ovarian sympathectomy on follicular development during compensatory ovarian hypertrophy in the guinea-pig

Changes in Ovarian Norepinephrine Synthesis throughout the Follicular and Luteal Phases1

A role for alternative pathway catecholamines in the regulation of steroidogenesis in cow luteal cells

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