Beschleunigung von Entgiftungsreaktionen durch verschiedene Insecticide

Effect of environmental factors on drug metabolism: Decreased plasma half‐life of antipyrine in workers exposed to chlorinated hydrocarbon insecticides

“…However, evidence in favor of an inducing effect of benzene hexachloride on drug hydroxylation has been reported in dogs 16 and in rats. 9 Experiments in progress'* in this laboratory show that the metabolism of antipyrine in the isolated perfused rat liver is significantly enhanced 4 days after a single dose of lindane ( 60 mg. per kilogram intra peritoneally) compared with that in controls.…”

Interactions between DDT Analogs and Microsomal Epoxidase Systems

“…Unaware of this discovery and seeking to conserve tissue, Wong used microsomes from rats fed DDT to study the effect of dietary DDT on soluble liver proteins (29) in experiments on aldrin epoxidation and found them to be more active than microsomes from untreated rats (2,9). Subsequently, others (9,10) demonstrated an inductive effect of DDT on microsomal oxidations. The phenomenon of induction, noted by the appearance of increased amounts of an enzymic activity, may be contrasted too with alterations in metabolism brought about by genetic selection, as in the case of developing insecticidal resistance, in that changes occur in only one generation and after only brief exposure to the inducing agent.…”

Nutritional Interactions in Dieldrin Toxicity

“…Mixed function oxidases have been studied extensively in recent years, particularly the induction of these enzymes by exogenous chemicals. Dieldrin is active as an inducer of these systems (2) along with many other chemicals and thus its influence on the metabolism of polyunsaturated fatty acids may be another manifestation of the induction of microsomal oxidases. This induction results in a stimulation of the transformation of oleic and linoleic acids to their derivative acids.…”