Nutritional Interactions in Dieldrin Toxicity

Tinsley, Ian J.

doi:10.1021/jf60148a005

Cited by 15 publications

(7 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…toxicity is accentuated in rats raised on rations containing low levels of protein, whereas in our laboratory we have observed that dieldrin accentuated an essential fatty acid deficiency in the rat (2). In extending these studies to include other nutritional variables it seemed prubable that a tmhiamine deficiency should influence dieldrin toxicity.…”

mentioning

confidence: 65%

See 1 more Smart Citation

An Interaction of Dieldrin with Thiamine

Tinsley

1968

Experimental Biology and Medicine

Self Cite

View full text Add to dashboard Cite

mentioning

confidence: 65%

“…A more detailed description of the composition of this ration is given in a previous publication (2). Dieldrin (analytical standard grade) was added to the ration dissolved in corn oil.…”

mentioning

confidence: 99%

An Interaction of Dieldrin with Thiamine

Tinsley

1968

Experimental Biology and Medicine

Self Cite

View full text Add to dashboard Cite

“…Tinsley (1966) and Tinsley and Lowry (1969) noted increased conversion of long chain fatty acids to more unsaturated acids such as 18:2 and 20:4 when dieldrin was fed to rats. These workers attributed this accumulation by the dieldrin to the blockage in the synthesis of more complex lipids since stearic, palmitic and polyunsaturated fatty acids are most likely associated with phosphoglycerides.…”

Section: Discussionmentioning

confidence: 99%

“…Lee et al (1964) decreased vitamin A stores in rats by feeding dieldrin. Tinsley (1966) demonstrated that dieldrin ingestion would accentuate an essential fatty acid deficiency in rats. Srivastava et al (1960) noted perosis-like lesions of the hocks of chicks fed chlorinated hydrocarbons.…”

mentioning

confidence: 99%

Interaction of Vitamin A and Dieldrin on Mallard Liver Lipids and Biotin Content ,

et al. 1972

View full text Add to dashboard Cite

The effect of chronic ingestion of a low level of dieldrin (1 mg./kg. body weight) was studied on Mallards fed a diet either adequate or deficient in vitamin A. No gross symptoms of dieldrin toxicity were observed after twelve weeks on experimental diets. After five weeks marked foot pad keratinzation occurred in pesticide-fed ducks. Vitamin A deficient birds had significantly reduced liver weight when compared to the other treatment ducks. There was no effect of feeding pesticide on vitamin A content of the liver, but biotin per gram of liver was significantly (P <0.05) lower in the pesticide-fed ducks than in the nonpesticidefed birds.Liver fatty acid composition was altered either by pesticide ingestion or vitamin A deficiency. There were significant (P<0.05) accumulations of stearic and palmitic acids with a comparable reduction of their monoenoic derivatives in the dieldrin-fed ducks when vitamin A was adequate in the diet. There were higher levels of long chain polyunsaturated fatty acids (18:2, 18:3 and 20:4) in the dieldrin-fed birds when vitamin A was deficient.Ingestion of dieldrin at this level had a marked depressant effect on liver biotin content and altered fatty acid composition possibly by interference in enzyme systems involved in lipid metabolism. ABSTRACTFree plasma amino acid levels were studied in five pure strains of White Leghorns. Two blood samples were drawn from the birds at 275 and 500 days of age respectively. The preliminary results, on the purebred array only, show that lines A and E have, in general, the highest level, while line C has the lowest level. Five of the twenty-one amino acids investigated show significant line differences: threonine, serine, proline, valine and isoleucine. Estimates of heritability of these amino acids are also reported. These line differences offer a strong indication that heredity plays an important role in the control of free plasma amino acid levels on fasted chickens.

show abstract

“…Ration Composition. With the exception that a-protein was substituted for casein, the composition of the semisynthetic ration used was the same as that given in a previous publication (Tinsley, 1966). The ration contained 22% protein, 5% fat, 4% salts, and 67% carbohydrate, with adequate amounts of micronutrients being incorporated as the pure compounds.…”

Section: Methodsmentioning

confidence: 99%