Berberine inhibits the proliferation and migration of breast cancer ZR-75-30 cells by targeting Ephrin-B2

Ma, Weina; Zhu, Man; Zhang, Dongdong; Yang, Lei; Yang, Tianfeng; Li, Xin; Zhang, Yanmin

doi:10.1016/j.phymed.2016.12.013

Cited by 70 publications

(53 citation statements)

References 22 publications

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“…2257 cancer cell (TNBC) lines (IC 50 : 43.28 µM for BT549 and 47.51 µM for MDA-MB-231 cells) in vitro 169 and inhibited the proliferation and migration of breast cancer ZR-75-30 cells (IC 50 : 5.30 µM) by targeting Ephrin-B2 170. …”

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confidence: 99%

Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

133

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Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014-2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti-inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.

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mentioning

confidence: 99%

Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

133

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“…In breast cancer cells, BBR inhibited cell proliferation and metastasis by targeting ephrin-B2 and inhibiting the expression of MMP-2 and MMP-9. 48 In addition, BBR inhibited the expression of MMP-2 and MMP-9 via downregulation of TGF-β1. 49 In melanoma, BBR inhibited the EMT through downregulation of RARα and upregulation of RARβ, which resulted in inhibition of the PI3K/Akt signaling pathway.…”

Section: Bbr Inhibits Cell Invasion and Metastasismentioning

confidence: 98%

<p>The Anti-Cancer Mechanisms of Berberine: A Review</p>

Wang¹,

Liu²,

Du³

et al. 2020

CMAR

143

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Berberine (BBR) has been extensively studied in vivo and vitro experiments. BBR inhibits cell proliferation by regulating cell cycle and cell autophagy, and promoting cell apoptosis. BBR also inhibits cell invasion and metastasis by suppressing EMT and down-regulating the expression of metastasis-related proteins and signaling pathways. In addition, BBR inhibits cell proliferation by interacting with microRNAs and suppressing telomerase activity. BBR exerts its anti-inflammation and antioxidant properties, and also regulates tumor microenvironment. This review emphasized that BBR as a potential antiinflammation and antioxidant agent, also as an effective immunomodulator, is expected to be widely used in clinic for cancer therapy.

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“…( S )‐scoulerine is the branch point intermediate in the biosynthetic pathway that leads to the formation of protoberberine, protobine and benzophenanthridine alkaloids ,. These alkaloids and their substituents have been demonstrated to possess antimicrobial, antiprotozoal, antibacterial, antitumor, and anti‐HIV properties, along with several other pharmacological properties, such as antihypertensive, antiarrhythmic, and anti‐diabetic . Berberine has also been shown to possess a cholesterol‐lowering property, thereby exerting a protective role in atherosclerosis .…”

Section: Berberine Bridge Enzyme (Bbe)mentioning

confidence: 99%

Biocatalyzed C−C Bond Formation for the Production of Alkaloids

2018

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Traditional methods of chemical synthesis of alkaloids exhibit various problems such as lack of enantioselectivity, the use of toxic chemical and intermediates, and multiple numbers of synthetic steps. Consequently, various enzymatic methods for the formation of CÀC bonds in the alkaloid skeleton have been developed. Herein, we report advances achieved in the enzymatic or chemo-enzymatic synthesis of pharmaceutically important alkaloids that employ three CÀC bond forming enzymes: two Pictet-Spenglerases and the oxidative CÀC bond forming flavoenzyme Berberine Bridge Enzyme. Protein engi-neering studies, improving the substrate scope of these enzymes, and thereby leading to the synthesis of non-natural alkaloids possessing higher or newer pharmacological activities, are also discussed. Furthermore, the integration of these biocatalysts with other enzymes, in multi-enzymatic cascades for the enantioselective synthesis of alkaloids, is also reviewed. Current results suggest that these enzymes hold great promise for the generation of CÀC bonds in the selective synthesis of alkaloid compounds possessing diverse pharmacological properties.

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Berberine inhibits the proliferation and migration of breast cancer ZR-75-30 cells by targeting Ephrin-B2

Cited by 70 publications

References 22 publications

Biologically active isoquinoline alkaloids covering 2014–2018

Biologically active isoquinoline alkaloids covering 2014–2018

<p>The Anti-Cancer Mechanisms of Berberine: A Review</p>

Biocatalyzed C−C Bond Formation for the Production of Alkaloids

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