Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of β-amyloid in APP/tau/PS1 mouse model of Alzheimer's disease

Huang, Min; Jiang, Xin; Liang, Yubin; Liu, Qiong; Chen, Siyan; Guo, Yi

doi:10.1016/j.exger.2017.02.004

Cited by 132 publications

(98 citation statements)

References 44 publications

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“…Furthermore, intracerebral administration of STZ led to features characteristic of AD, including cognitive impairment and ACh homeostasis disturbances [160], which could be alleviated by insulin sensitizers [15,161]. Our literature survey indicated that berberine directly protects the brain cells against damages associated with dementia [27,29,32,34,39], possibly via antioxidative and anti-inflammatory effects [28,35,37,42], and also by reducing A levels [31,38]. Berberine was able to promote cognitive functions [38,40], through enhancing cholinergic neurotransmission [30,33,36,41].…”

Section: Direct Evidence Supporting Berberine's Antidementia Effectsmentioning

confidence: 97%

“…Potential benefits were demonstrated in 16 nondiabetic studies (Table 1) and in 9 studies using diabetic models (Table 2). In nondiabetic models, berberine protected learning and memory in heavy metal-induced AD [28], Aβ-induced memory deficits model [34], familial AD models [29,35,38] and D-galactose-induced brain damage [40,145]. In the rat VaD model induced by chronic cerebral hypoperfusion, berberine protected hippocampal calyculin A1 (CA1) neurons and prevented memory deficit [27].…”

Section: Ischemia-reperfusion Injury In T2dmmentioning

confidence: 99%

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Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Shinjyo

Parkinson

Bell

et al. 2020

Journal of Integrative Medicine

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Section: Direct Evidence Supporting Berberine's Antidementia Effectsmentioning

confidence: 97%

Section: Ischemia-reperfusion Injury In T2dmmentioning

confidence: 99%

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Shinjyo

Parkinson

Bell

et al. 2020

Journal of Integrative Medicine

View full text Add to dashboard Cite

show abstract

“…For instance, besides normal defense of inflammation and oxidative stress, decreased Aβ 40 and increased Aβ 42 in the hippocampal region were noticed in BBR treated rat model (Ghareeb et al, ). It was reported that BBR improves spatial learning capacity and memory retention in the hippocampus of triple‐transgenic mouse model of AD by promoting autophagic clearance (Aβ clearance) and inhibit Aβ production (Huang et al, ). In calyculin‐induced neuroblastoma‐2a cells, BBR attenuates cytotoxicity in metabolism and viability and reverses axonal transport impairment significantly, which underlie memory deficits in rates by modulating the activity of PP‐2A (Liu et al, ).…”

Section: Other Neuroprotective Pathwaysmentioning

confidence: 99%

“…In calyculin‐induced neuroblastoma‐2a cells, BBR attenuates cytotoxicity in metabolism and viability and reverses axonal transport impairment significantly, which underlie memory deficits in rates by modulating the activity of PP‐2A (Liu et al, ). One more way of BBR's treatment to AD is the processing of APP to reduce Aβ peptide (Huang et al, ). In the transgenic mouse model of AD, BBR is found to regulate APP processing by decreasing the levels of C‐terminal fragments of APP and hyperphosphorylation of APP and tau (Mendelson, Evans, & Hla, ).…”

Section: Other Neuroprotective Pathwaysmentioning

confidence: 99%

Berberine: Pathways to protect neurons

Lin

Zhang

2018

Phytotherapy Research

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Berberine, an isoquinoline alkaloid, is demonstrated to have a variety of pharmacologic effects. Widely used as nonprescription drug for diarrhea, berberine has also broadened its applications in therapies of cardiovascular diseases, diabetes mellitus, tumor, and so forth. However, researches about berberine's protective effects on nervous system are still so insufficient that clinical uses cannot popularize and underlying molecules mechanisms are confused and incomplete. Well-known pathways such as Pl3K/Akt/Bcl-2 pathway, Nrf2/HO-1 pathway, and MAPK signaling pathway help berberine to protect neurons through antiapoptotic, antioxidative, and anti-inflammatory activities. New hypotheses have been raised consistently to explore more possible ways of berberine preventing nerves from injuries as attention on its neuroprotective properties is increasing. Therefore, this review is trying to analyze these mechanisms, which actually play roles in neuronal disease models such as brain ischemia, Alzheimer's disease, and experimental autoimmune encephalomyelitis. Much more understanding about how berberine mediates these pathways provides novel insights into the clinical treatment of neurological disorders.

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“…BBR could reduce the accumulation of Aβ by activating AMPactivated protein kinase in N2a/APP695sw cells (23), alleviate Aβ induced mitochondrial dysfunction and synaptic loss in primary cultured hippocampal neurons (24). In addition, BBR improves cognitive impairment by promoting autophagic clearance and inhibiting production of Aβ in APP/Tau/PS1 mouse (25).…”

Section: Introductionmentioning

confidence: 99%

Ameliorating Ribosylation-induced Aβ Pathology by Berberine via Inhibiting mTOR/p70S6K Signaling

Wang

Qian

Huang

et al. 2020

Preprint

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Abstract Background: Berberine (BBR) plays a neuroprotective role in the pathogenesis of Alzheimer’s disease (AD), inhibiting β-amyloid (Aβ) production and promoting Aβ clearance. Advanced glycation end products (AGEs) promote Aβ aggregation and tau hyperphosphorylation. The activation of mTOR signaling occurring at the early stage of AD has a prominent impact on the Aβ production. This work focused on whether BBR regulates the production and clearance of ribosylation-induced Aβ pathology via inhibiting mTOR signaling.Methods: Western Blot and Immunofluorescence staining were used to detect the related proteins of the mammalian target of Rapamycin(mTOR) signaling pathway and autophagy, as well as the related kinases of Aβ generation and clearance. Tissue sections and Immunofluorescence staining were used to observe Aβ1-42 in APP/PS1 mice hippocampal. Morris water maze (MWM) test was used to measure the spatial learning and memory of APP/PS1 mice.Results: BBR improves spatial learning and memory of APP/PS1 mice. BBR limits the activation of mTOR/p70S6K signaling pathway and enhances autophagy process. BBR reduces the activity of BACE1and γ-secretase induced by D-ribose, and enhances Aβ-degrading enzymes and Neprilysin, and inhibits the expression of Aβin APP/PS1 mice.Conclusions: BBR ameliorates ribosylation-induced Aβ pathology via inhibiting mTOR/p70S6K signaling, and improves spatial learning and memory of the APP/PS1 mice.

show abstract

Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of β-amyloid in APP/tau/PS1 mouse model of Alzheimer's disease

Cited by 132 publications

References 44 publications

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Berberine: Pathways to protect neurons

Ameliorating Ribosylation-induced Aβ Pathology by Berberine via Inhibiting mTOR/p70S6K Signaling

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