Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Shinjyo, Noriko; Parkinson, James; Bell, Jimmy D.; Katsuno, Tatsuro; Bligh, S. W. Annie

doi:10.1016/j.joim.2020.01.004

Cited by 32 publications

(39 citation statements)

References 224 publications

(423 reference statements)

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“…Large-scale researches have demonstrated a wide range of BBR pharmacological activities including antibacterial, antidiabetic, anti-inflammatory, antidiarrheal, antiparasitic, antihypertensive, hypolipidemic, and fungicide properties. [55][56][57][58][59][60] Many experiments on BBR have demonstrated its anti-inflammatory effects on the gastrointestinal system. 20,61 BBR has been also used as an effective therapeutic agent for Inflammatory Bowel Disease (IBD) for several years.…”

Section: Cancer Therapymentioning

confidence: 99%

Berberine: A novel therapeutic strategy for cancer

et al. 2020

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Cancer, even currently, is one of the main reasons for mortality and morbidity, worldwide. In recent years, a great deal of effort has been made to find efficient therapeutic strategies for cancer, however, particularly with regards to side effects and the possibility of complete remission. Berberine (BBR) is a nature‐driven phytochemical component originated from different plant groups such as Berberis vulgaris, Berberis aquifolium, and Berberis aristata. BBR is a well‐known nutraceutical because of its wide range of pharmacological activities including anti‐inflammatory, antidiabetic, antibacterial, antiparasitic, antidiarrheal, antihypertensive, hypolipidemic, and fungicide. In addition, it exhibits inhibitory effects on multiple types of cancers. In this review, we have elaborated on the anticancer effects of BBR through the regulation of different molecular pathways such as: inducing apoptosis, autophagy, arresting cell cycle, and inhibiting metastasis and invasion.

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Section: Cancer Therapymentioning

confidence: 99%

Berberine: A novel therapeutic strategy for cancer

et al. 2020

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“…In recent years, a growing number of studies have discovered the potential value of Chinese traditional medicine in diseases' treatment (Hao P et al, 2017). Berberine (BBR), a famous herb extract generally isolated from rhizoma coptidis rhizomes and cortex phellodendri, has been regarded as a potential and promising drug for preventing diabetes and its complications (Wu Z et al, 2020;Shinjyo N et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Berberine Interferes With the Abnormal Glomerular Mesangial Cell C Ycle Re-Distribution to Alleviate Diabetic Nephropathy via PI3K/AKT/AS160/GLUT4 Signaling Pathway

Guan

Zeng

et al. 2021

Preprint

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Background: Berberine plays a critical role of the glomerular mesangial cells (GMCs) abnormal proliferation during diabetic nephropathy (DN). This study aims to explore the intervention effect of BBR on DN mice and investigate the potential mechanism targeting abnormal GMCs proliferation. Methods: Streptozotocin-induced mice were used to determine the effect of BBR on the renal injury. In vitro, GMCs are cultured in high glucose (30 mmol/L). EdU and MTT assay are used for screening the optimum BBR concentration and intervention time. Flow cytometry is applied to analyze the cell cycle re-distribution. Western blot and RT-qPCR are devoted to studying the relative expression of molecules in PI3K/AKT/AS160/GLUT4 signaling pathway. Additionally, 2-NBDG assay is selected for measuring the glucose uptake of GMCs. Results: HE and PAS staining revealed that the notable mesangial matrix expansion, glomerular hypertrophy and glycogen deposition in diabetic kidney can be alleviated after BBR treatment. Moreover, BBR significantly reduced the positive expression of GLUT4 in tubulointerstitium and glomerular region. EdU shows that high glucose induces the abnormal proliferation of GMCs, which becomes more apparently as time goes on (20h→28h). Meantime, BBR (60 and 90 μmol/L) can not only increase the proportion of G1 phase, but also reduce the proportion of S phase. After 24 h, the same sort of phenomenon has cropped up in BBR (30 μmol/L) group. BBR (60 μmol/L)) significantly degraded the levels of PI3K-p85, p-AKT, p-AS160, and the membrane-GLUT4, while indistinguishable changes of their total protein expressions. Additionally, BBR prominently reduced the glucose uptake and retard the cell cycle of GMCs to stay at G1 phase. Conclusions: The rearrangement effect of BBR on cell cycle is related with PI3K/AKT signaling pathway and GLUT4 trafficking. The key findings of our study collectively indicate that the treatment of GMCs proliferation can be a novel therapeutic strategy in DN.

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“…The diversity of berberine's effect and potential to treat numerous diseases has been extensively reviewed and include antibacterial [14], anti-inflammatory [15] antidiabetic [16], antiobesity [17] and antidementia [18] effects. The best way to explain these effects is of course the polypharmacology principle of action, which is evident for multifunctional natural products like berberine [19].…”

Section: Introductionmentioning

confidence: 99%

“…The best way to explain these effects is of course the polypharmacology principle of action, which is evident for multifunctional natural products like berberine [19]. As with other diseases, the therapeutic potential of berberine for cancer is also mediated through effect on diverse The diversity of berberine's effect and potential to treat numerous diseases has been extensively reviewed and include antibacterial [14], anti-inflammatory [15] antidiabetic [16], antiobesity [17] and antidementia [18] effects. The best way to explain these effects is of course the polypharmacology principle of action, which is evident for multifunctional natural products like berberine [19].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Berberine Inspired Anticancer Approaches: From Drug Combination to Novel Formulation Technology and Derivatization

Habtemariam

2020

Molecules

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Berberine is multifunctional natural product with potential to treat diverse pathological conditions. Its broad-spectrum anticancer effect through direct effect on cancer cell growth and metastasis have been established both in vitro and in vivo. The cellular targets that account to the anticancer effect of berberine are incredibly large and range from kinases (protein kinase B (Akt), mitogen activated protein kinases (MAPKs), cell cycle checkpoint kinases, etc.) and transcription factors to genes and protein regulators of cell survival, motility and death. The direct effect of berberine in cancer cells is however relatively weak and occur at moderate concentration range (10–100 µM) in most cancer cells. The poor pharmacokinetics profile resulting from poor absorption, efflux by permeability-glycoprotein (P-gc) and extensive metabolism in intestinal and hepatic cells are other dimensions of berberine’s limitation as anticancer agent. This communication addresses the research efforts during the last two decades that were devoted to enhancing the anticancer potential of berberine. Strategies highlighted include using berberine in combination with other chemotherapeutic agents either to reduce toxic side effects or enhance their anticancer effects; the various novel formulation approaches which by order of magnitude improved the pharmacokinetics of berberine; and semisynthetic approaches that enhanced potency by up to 100-fold.

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Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Cited by 32 publications

References 224 publications

Berberine: A novel therapeutic strategy for cancer

Berberine: A novel therapeutic strategy for cancer

Berberine Interferes With the Abnormal Glomerular Mesangial Cell C Ycle Re-Distribution to Alleviate Diabetic Nephropathy via PI3K/AKT/AS160/GLUT4 Signaling Pathway

Recent Advances in Berberine Inspired Anticancer Approaches: From Drug Combination to Novel Formulation Technology and Derivatization

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