Berberine attenuates apoptosis in rat retinal Müller cells stimulated with high glucose via enhancing autophagy and the AMPK/mTOR signaling

Chen, Han; Ji, Yingshi; Yan, Xin; Su, Guanfang; Chen, Li; Xiao, Jun

doi:10.1016/j.biopha.2018.09.140

Cited by 64 publications

(43 citation statements)

References 35 publications

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“…A related component in this process is that of ROS, which induces oxidative stress and autophagy through AMPK/mTOR. In specific, AMPK can indirectly promote autophagy by inhibiting mTOR activity [50,51]. In this study, we found that TICs co-cultured with hUMSC supernatant reduced ROS level which is resulted from CDDP-induced oxidative stress, thereby reducing the activity of AMPK, and consequently reduces the autophagy.…”

Section: Discussionmentioning

confidence: 63%

hUMSC transplantation restores ovarian function in POI rats by inhibiting autophagy of theca-interstitial cells via the AMPK/mTOR signaling pathway

Bao

Cui

et al. 2020

Stem Cell Res Ther

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Background: Previous studies of primary ovarian insufficiency (POI) have focused on granulosa cells (GCs) and ignored the role of theca-interstitial cells (TICs). This study aims to explore the mechanism of the protective effects of human umbilical cord-derived mesenchymal stem cells (hUMSCs) on ovarian function in POI rats by regulating autophagy of TICs. Methods: The POI model was established in rats treated with cisplatin (CDDP). The hUMSCs were transplanted into POI rats by tail vein. Enzyme-linked immunosorbent assay (ELISA) analysis, hematoxylin and eosin (HE) staining, and immunohistochemistry were used to measure the protective effects of hUMSCs. The molecular mechanisms of injury and repairment of TICs were assessed by immunofluorescence, transmission electron microscope (TEM), flow cytometry (FCM), western blot, and quantitative real-time polymerase chain reaction (qRT-PCR). Results: In vivo, hUMSC transplantation restored the ovarian function and alleviated the apoptosis of TICs in POI rats. In vitro, hUMSCs reduced the autophagy levels of TICs by reducing oxidative stress and regulating AMPK/mTOR signaling pathway, thereby alleviating the apoptosis of TICs. Conclusion: This study indicates that hUMSCs protected ovarian function in POI by regulating autophagy signaling pathway AMPK/mTOR.

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Section: Discussionmentioning

confidence: 63%

hUMSC transplantation restores ovarian function in POI rats by inhibiting autophagy of theca-interstitial cells via the AMPK/mTOR signaling pathway

Bao

Cui

et al. 2020

Stem Cell Res Ther

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“…Evidence suggests that the status of retinal neuronal structure and vasculature can reflect that of the cerebral nervous system [211]. Our literature survey revealed that berberine could prevent diabetic retinopathy [64][65][66]. Although the mechanistic link between retinal injuries and cognitive dysfunction is not clear, these data support that berberine could prevent diabetes-associated damages to the neuronal network in the central nervous system, including retina.…”

Section: Retinal Protectionmentioning

confidence: 59%

“…As shown in Table 8, berberine protected retinal Müller cells from HG-and LDL-induced damage via enhancing AMPK signaling [65,66] and prevented retinal endothelial injuries induced by HGactivated leukocytes [64].…”

Section: Diabetic Retinopathymentioning

confidence: 99%

“…AMPK is a serine/threonine kinase that is activated in response to adenosine triphosphate (ATP) depletion; its action is to restore cellular ATP levels and energy supply, acting as an energy sensor and a metabolic master regulator [213]. Enhanced AMPK activity, upon berberine-treatment, has been observed in several studies using diabetic animal models [63,65,102,128] as well as in vitro models [57,65,66,114,128,132,135]. However, it is not clear whether the glucose-lowering effect is indeed mediated by AMPK activation [57].…”

Section: Enhancing Glucose and Lipid Metabolismmentioning

confidence: 99%

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Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Shinjyo

Parkinson

Bell

et al. 2020

Journal of Integrative Medicine

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…232 It also protected rat retinal Müller cells from highglucose-induced apoptosis by enhancing autophagy and activating the AMPK/mTOR signaling pathway. 233 Acting on the TGFβ1-PI3K/Akt pathway, berberine reduced injury to podocytes caused by exosomes derived from high glucoseinduced mesangial cells. 234 Berberine showed good effects on bone parameters in the treatment of HFD-fed/ streptozocin-induced diabetic rats and, thus, could have therapeutic potential in diabetic osteoporosis.…”

Section: Effect On Diabetes and Its Complicationsmentioning

confidence: 99%

Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

116

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Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014-2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti-inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.

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Berberine attenuates apoptosis in rat retinal Müller cells stimulated with high glucose via enhancing autophagy and the AMPK/mTOR signaling

Cited by 64 publications

References 35 publications

hUMSC transplantation restores ovarian function in POI rats by inhibiting autophagy of theca-interstitial cells via the AMPK/mTOR signaling pathway

hUMSC transplantation restores ovarian function in POI rats by inhibiting autophagy of theca-interstitial cells via the AMPK/mTOR signaling pathway

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Biologically active isoquinoline alkaloids covering 2014–2018

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