Berberine as a promising anti-diabetic nephropathy drug: An analysis of its effects and mechanisms

Ni, Wei‐Jian; Ding, Hai-Hua; Tang, Ling‐Zhi

doi:10.1016/j.ejphar.2015.04.017

Cited by 103 publications

(88 citation statements)

References 51 publications

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“…Its main components include alkaloids and lignans. Among the alkaloids, berberine is a main active component of Rhizoma coptidis [34]. The studies found that Rhizoma coptidis can reduce weight, lower lipids [56], reduce lipid synthesis [57], and inhibit adipogenesis [58].…”

Section: Resultsmentioning

confidence: 99%

Herbal Medicine for the Treatment of Obesity: An Overview of Scientific Evidence from 2007 to 2017

Liu

Sun

Yao

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Obesity is a very common global health problem, and it is known to be linked to cardiovascular and cerebrovascular diseases. Western medical treatments for obesity have many drawbacks, including effects on monoamine neurotransmitters and the potential for drug abuse and dependency. The safety of these medications requires improvement. Herbal medicine has been used for treatment of disease for more than 2000 years, and it has proven efficacy. Many studies have confirmed that herbal medicine is effective in the treatment of obesity, but the mechanisms are not clear. This article will discuss the possible effects and mechanisms of herbal medicine treatments for obesity that have been reported in the past decade.

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Section: Resultsmentioning

confidence: 99%

Herbal Medicine for the Treatment of Obesity: An Overview of Scientific Evidence from 2007 to 2017

Liu

Sun

Yao

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…For example, BBR improves myocardial dysfunction induced by hyperglycemia/hypercholesterolemia by increasing the expression of cardiac fatty acid transport proteins, fatty acid ß-oxidase, GLUT-4 and PPARγ, while decreasing PPARα expression [89], and treatment of diabetic rats with BBR improves the recovery of cardiac systolic/diastolic function and myocardial apoptosis after myocardial ischemia/reperfusion [63]. Due to its various pharmacological actions, BBR is also believed to have a potential therapeutic action on diabetic nephropathy through several mechanisms [90]. BBR improves fasting blood glucose and lipid metabolism, restores renal functional parameters, prevents structural alterations of kidney tissues and increases the levels of E prostanoid receptor 4 (EP4), reduces inflammation and the deposition of extracellular matrix in diabetic rats [90; 91].…”

Section: Type 2 Diabetesmentioning

confidence: 97%

Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies

2015

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“…Berberine, an isoquinoline‐type alkaloid, is the major active constituent, which is characterized by a diversity of pharmacological effects that have applications in different therapeutic areas . For example, berberine and its synthetic derivatives have been investigated for application in cancer and inflammation , obesity , diabetes , atherosclerosis , Alzheimer's disease , rheumatoid arthritis , and cardiovascular diseases .…”

Section: Introductionmentioning

confidence: 99%

Aptamer-functionalized Fe₃O₄magnetic nanoparticles as a solid-phase extraction adsorbent for the selective extraction of berberine fromCortex phellodendri

Jiang

Chen

et al. 2017

J. Sep. Sci.

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The extraction adsorbent was fabricated by immobilizing the highly specific recognition and binding of aptamer onto the surface of Fe O magnetic nanoparticles, which not only acted as recognition elements to recognize and capture the target molecule berberine from the extract of Cortex phellodendri, but also could favor the rapid separation and purification of the bound berberine by using an external magnet. The developed solid-phase extraction method in this work was useful for the selective extraction and determination of berberine in Cortex phellodendri extracts. Various conditions such as the amount of aptamer-functionalized Fe O magnetic nanoparticles, extraction time, temperature, pH value, Mg concentration, elution time and solvent were optimized for the solid-phase extraction of berberine. Under optimal conditions, the purity of berberine extracted from Cortex phellodendri was as high as 98.7% compared with that of 4.85% in the extract, indicating that aptamer-functionalized Fe O magnetic nanoparticles-based solid-phase extraction method was very effective for berberine enrichment and separation from a complex herb extract. The applicability and reliability of the developed solid-phase extraction method were demonstrated by separating berberine from nine different concentrations of one Cortex phellodendri extract. The relative recoveries of the spiked solutions of all the samples were between 95.4 and 111.3%, with relative standard deviations ranging between 0.57 and 1.85%.

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Berberine as a promising anti-diabetic nephropathy drug: An analysis of its effects and mechanisms

Cited by 103 publications

References 51 publications

Herbal Medicine for the Treatment of Obesity: An Overview of Scientific Evidence from 2007 to 2017

Herbal Medicine for the Treatment of Obesity: An Overview of Scientific Evidence from 2007 to 2017

Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies

Aptamer-functionalized Fe₃O₄magnetic nanoparticles as a solid-phase extraction adsorbent for the selective extraction of berberine fromCortex phellodendri

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Berberine as a promising anti-diabetic nephropathy drug: An analysis of its effects and mechanisms

Cited by 103 publications

References 51 publications

Herbal Medicine for the Treatment of Obesity: An Overview of Scientific Evidence from 2007 to 2017

Herbal Medicine for the Treatment of Obesity: An Overview of Scientific Evidence from 2007 to 2017

Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies

Aptamer-functionalized Fe3O4magnetic nanoparticles as a solid-phase extraction adsorbent for the selective extraction of berberine fromCortex phellodendri

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Aptamer-functionalized Fe₃O₄magnetic nanoparticles as a solid-phase extraction adsorbent for the selective extraction of berberine fromCortex phellodendri