�ber die Harns�ure- und andere Clearances nach intraven�ser Gabe von Fursemid beim Menschen

Schirmeister, J; Willmann, Hildegard

doi:10.1007/bf01480095

Cited by 49 publications

(10 citation statements)

References 26 publications

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“…In human adults peak plasma levels of sulphur-35 labelled frusemide were found at 30 minutes after intramuscular administration, and 60 minutes after oral administration; approximately 80% of the labelled dose being recovered in the urine after intravenous and intramuscular administration (Calesnick, Christensen, and Richter, 1966). It is rapidly excreted in adults by filtration and tubular secretion in the urine (Deetjen, 1966), and it is also excreted in the bile and faeces (Schirmeister and Willmann, 1964). Excretion of frusemide like other drugs may be slower in the newborn.…”

Section: Discussion and Commentmentioning

confidence: 99%

“…However, frusemide is an effective diuretic even in the presence of greatly impaired renal function (Vorburger, 1964;Muth, 1966;Reubi, 1966), and Vorburger (1964) has observed increases in GFR in patients in renal failure, with frusemide. A marked rise in renal blood flow occurs with frusemide (Schirmeister and Willmann, 1964;Vorburger, 1964;and Hook et al, 1966). Barger (1966) -Effect offrusemide on respiratory rate and weight.…”

Section: Discussion and Commentmentioning

confidence: 99%

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Frusemide in heart failure of infancy

Richardson¹

1971

Archives of Disease in Childhood

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Richardson, Heather (1971). Archives of Disease in Childhood, 46, 520. Frusemide in heart failure of infancy. Twelve infants with heart failure and one with perinatal oedema were treated with intramuscular frusemide (1 0-1 -25 mg/kg). Frusemide was found to be a safe effective diuretic in infants with heart failure, resulting in clinical improvement, marked excretion of water, sodium, and chloride, with a lesser and more variable effect on potassium excretion. Complications were uncommon with this dose. The drug is most effective in acute pulmonary oedema or acute worsening of heart failure, but day-to-day control of persistent heart failure is more easily obtained by using repeated doses of oral or intramuscular frusemide plus, if needed, aldactone A or triamterene.There is little quantitative information on the use of frusemide in infancy. Reimold (1964) reports on its administration to 3 infants with perinatal oedema but observed little improvement; however, one infant aged 6 weeks, with heart failure due to myocarditis, responded well to a dose of 0 4-1 mg/kg of frusemide.Thieffry, Joly, and Ferchiou (1969) reported a significant diuresis and natriuresis in 8 infants with congenital heart disease, and 5 infants with other causes of fluid retention. In one infant, circulatory collapse was provoked, but they concluded that frusemide was a safe effective diuretic in a dose of 0 * 7-1 * 25 mg/kg. Therefore it was decided to carry out a further study to assess the usefulness of frusemide as a diuretic in a series of infants admitted with fluid retention predominantly due to heart failure.Short-term Studies Eleven infants aged 3 days to 6 months were studied. Details of diagnosis, sex, age on admission, and mode of presentation are given in Table I. The usual criteria for a diagnosis of heart failure were used (Lees, 1969); however, tachypnoea of more than 60 respirations per minute and cardiac enlargement on x-ray in patients with congenital heart disease were considered to be sufficient to make the diagnosis. Of the 11 infants, 9 were moderately to critically ill, their most striking clinical features being tachypnoea and exhaustion (Table II). Frusemide in a dose of 1 0-1-25 mg/kg was given intramuscularly under the following conditions.(a) Initially, when a diagnosis of heart failure was made; (b) when deterioration in an infant's condition occurred, usually associated with increasing tachypnoea, and clinically attributed to increasing heart failure; and (c) when an increase in weight of 2% total body weight occurred in a 12-hour period.At the time of initial examination, 8 of the children had been digitalized and one had received one dose of mersalyl. During the period of the study no other diuretic therapy other than frusemide was given.Control urines (24-hour) were obtained from all the infants on admission, and twice a week thereafter. This was relatively easy in male infants using Paul's tubing. In female infants urine collecting bags (Down Bros.) were employed with less successful results. Accordingly, a...

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Section: Discussion and Commentmentioning

confidence: 99%

Section: Discussion and Commentmentioning

confidence: 99%

Frusemide in heart failure of infancy

Richardson¹

1971

Archives of Disease in Childhood

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“…factor considered important in the mechanism of action of thiazides (35). Previous reports have revealed the proportionate nature of sodium and calcium clearance rates under a variety of diuretic conditions (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). In the present studies we have confirmed that the ratio of calcium to sodium clearance rates is close to unity during 3% BWt Ringer's expansion and after the acute administration of furosemide.…”

Section: Clearance Datamentioning

confidence: 99%

“…Walser (1,2) and other investigators (3)(4)(5) found that the association between calcium and sodium clearances observed in the hydropenic state is not altered during diuresis induced by saline, mannitol, glucose, or water. Nor is this association diminished by most diuretics, since calcium excretion remains proportional to sodium excretion after administration of ethacrynic acid (6)(7)(8)(9), furosemide (7)(8)(9)(10)(11), and mercurials (5,12). Howvever, quantitative differences in the associated degree of calciuresis have been reported.…”

Section: Introductionmentioning

confidence: 99%

Micropuncture Study of Diuretic Effects on Sodium and Calcium Reabsorption in the Dog Nephron

Edwards¹,

Baer²,

Sutton³

et al. 1973

J. Clin. Invest.

135

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“…Single doses of chlorothiazide in man cause a fall in cardiac output, renal plasma flow and glomerular filtration rate (Crosley et al, 1960;Villareal et al, 1962). Similar studies with frusemide have shown a rise in renal blood flow and glomerular filtration rate (Buchborn & Anastasakis, 1964;Schirmeister & Willman, 1964;Heidland et al, 1964b;Vorburger, 1964;Jahnecke, Konietzko & Kruck, 1964). These findings have been questioned as the clearance techniques for measuring glomerular filtration rate and renal plasma flow are prone to large errors in situations of rapidly changing urine flow rates.…”

Section: Discussionmentioning

confidence: 90%

Observations of Renal Function in Patients Undergoing Therapeutic Diuresis with Frusemide

1970

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1.Changes in extracellular water, plasma volume, blood urea and glomerular filtration rate were recorded over intervals of up to 28 days in ten patients requiring diuretic therapy, eight of whom were oedematous and none of whom had obvious renal disease.2. Diuresis with frusemide was invariably associated with a fall in extracellular water and, in all but one instance, with a fall in plasma volume. It was also associated in every case with a rise in blood urea and fall in glomerular filtration rate.3. The fall in glomerular filtration rate was observed when the extracellular water and the plasma volume of each patient was still within the 'normal' range predicted on the basis of dry weight.4. Cessation of treatment was followed by a return to initial levels of the plasma volume and extracellular water, blood urea and glomerular filtration rate.5. When body weight became stable during the administration of frusemide, there was a partial re-expansion of the plasma volume and a tendency for the glomerular filtration rate to rise.6. The mechanism whereby these changes in renal function are brought about is unknown.

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�ber die Harns�ure- und andere Clearances nach intraven�ser Gabe von Fursemid beim Menschen

Cited by 49 publications

References 26 publications

Frusemide in heart failure of infancy

Frusemide in heart failure of infancy

Micropuncture Study of Diuretic Effects on Sodium and Calcium Reabsorption in the Dog Nephron

Observations of Renal Function in Patients Undergoing Therapeutic Diuresis with Frusemide

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