�ber das Verhalten des Rheumafaktors unter Penicillamin- und Penicillineinwirkung bei der prim�r chronischen Polyarthritis (Rheumatoid Arthritis)

Prohaska, E; Schwaegerl, W; Jesserer, H

doi:10.1007/bf01484505

Cited by 8 publications

(1 citation statement)

References 6 publications

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“…(A) The splitting action of the drug on serum macroglobulins, such as rheumatoid factor (almost always present in these patients), causes an excess of circulating IS immunoglobulin fragments with free -SH groups [Deutsch and Morton, 1957;Jaffe, 1963;Prohaska et al, 1965;Ohta et al, 1970], These could evoke antibodies which recognize the -SH groups as if they were specific antigenic sites and thus cross-react with the free -SH groups of the pre-keratinic molecular structures. There is an abundance of free -SH groups in the malpighian layer and these have been shown to bind pemphigus anti bodies specifically [Ogaica et al 1978].…”

Section: Discussionmentioning

confidence: 99%

Pemphigus Provoked by <i>D</i>(-)Penicillamine

Ruocco¹,

Luca²,

Pisani³

et al. 1982

Dermatology

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We present the results of our experiments with in vitro tissue cultures of normal human skin, carried out in order to clarify the mechanism(s) by which D(-)penicillamine provokes pemphigus. Various concentrations of D(-)penicillamine were added to the culture medium and produced acantholytic splitting, closely similar to control lesions produced by pemphigus serum, whereas no lesions occurred in controls cultured without the drug. This suggests to us that the pemphigus of D(-)penicillamine is due to biochemical mechanisms and is not mediated by antibodies. Integrating our data with those of previous clinical and experimental studies on idiopathic pemphigus vulgaris leads us to think that the pemphigus antigen(s) might be present in certain structures of the cell membrane of epithelial cells, which are linked with the initial phases of keratin differentiation.

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Section: Discussionmentioning

confidence: 99%

Pemphigus Provoked by <i>D</i>(-)Penicillamine

Ruocco¹,

Luca²,

Pisani³

et al. 1982

Dermatology

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D‐Penicillamin ‐ Herstellung und Eigenschaften

Weigert¹,

Offermanns²,

Scherberich³

1975

Angewandte Chemie

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D‐Penicillamine—Production and Properties

Weigert¹,

Offermanns²,

Degussa³

1975

Angew. Chem. Int. Ed. Engl.

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The non-naturally occurring amino acid D-penicillamine, originally only of interest as a key substance in the structural elucidation and total synthesis of penicillins is gaining increasing importance as a therapeutic, particularly in the long-term treatment of rheumatoid arthritis. D-Penicillamine which previously was obtained semi-synthetically by degradation of penicillins can now be totally synthesized using a new process which starts from isobutyraldehyde, sulfur, ammonia, and hydrogen cyanide and yields the racemate which is then selectively resolved. The biochemical behavior of D-penicillamine-chelate formation with heavy metal ions, cleavage of disulfide bridges, and condensation with aldehyde groups-affords information related to its therapeutic activity.

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�ber das Verhalten des Rheumafaktors unter Penicillamin- und Penicillineinwirkung bei der prim�r chronischen Polyarthritis (Rheumatoid Arthritis)

Cited by 8 publications

References 6 publications

Pemphigus Provoked by <i>D</i>(-)Penicillamine

Pemphigus Provoked by <i>D</i>(-)Penicillamine

D‐Penicillamin ‐ Herstellung und Eigenschaften

D‐Penicillamine—Production and Properties

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