<scp>D</scp>‐Penicillamin ‐ Herstellung und Eigenschaften

Weigert, W. M.; Offermanns, Heribert; Scherberich, Paul

doi:10.1002/ange.19750871003

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Synthesis Of Hexanal-dpa Adduct1

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Cited by 21 publications

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“…We followed the procedure of Weigert et al [30]. To DPA dissolved in hexanol we added hexanal (Sigma) in a 2:1 molar ratio and heated the mixture in a water bath at 701C for 2-3 h. After cooling, excess hexanol was removed by a vacuum.…”

Section: Synthesis Of Hexanal-dpa Adductmentioning

confidence: 99%

Single intratumoral injection of long-acting benzyl ester of D-penicillamine inhibits the growth of melanoma tumor in mice

Chvapil

Dorr²

2005

Anti-Cancer Drugs

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Using a murine model of melanoma we tested the effect of D-penicillamine administered in repetitive, daily injections, or as a single large dose injected either in saline or in a biodegradable polymer. We also studied the effect of a single intratumoral injection of benzyl-ester-D-penicillamine on the growth of the tumor. Daily injections of the drug or its administration in a polymer or benzyl-ester of D-penicillamine were all significantly inhibitory. The inhibitory effect manifested 4-5 days after injection. The inhibition lasted 8-10 days. There was no evidence of local or systemic toxicity and no changes in body weight. Several possible mechanisms for the inhibitory effect are presented.

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Section: Synthesis Of Hexanal-dpa Adductmentioning

confidence: 99%