Bentonite increases the corneal permeation of the drug from the tamarind gum hydrogels

Behera, Kiran Prava; Qureshi, Dilshad; Mohanty, Biswaranjan; Habibullah, Sk; Anis, Arfat; Shaikh, Hamid; Sarkar, Preetam; Verma, Sarika; Pal, Kunal

doi:10.1016/b978-0-12-819239-9.00001-4

Cited by 3 publications

(1 citation statement)

References 59 publications

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“…An ex vivo permeation study was done in Franz's diffusion cell to assess the ocular availability of the drug. The diffusion cell and the Franz diffusion cell have been reported to be efficient methods for the quantification of drug release from the formulations [15]. It was observed that the cumulative percentage drug permeation (CPDP) of F12 in 3 h (1.79±0.050%) was highest and the CPDP was decreased in F13 (1.56±0.027%) followed by F14 (1.19±0.058%) (Figure 7a).…”

Section: Ex-vivo Corneal Permeation Studymentioning

confidence: 99%

Formulation and evaluation of acetazolamide loaded in–situ gel for the treatment of glaucoma

ALI¹,

HABIBULLAH²,

GIRI³

et al. 2023

jrp

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The present research work was proposed to develop a pH triggered in-situ gel formulation for the ocular delivery of acetazolamide to treat glaucoma. Carbopol-934, Carbopol 940, Hydroxypropyl methylcellulose (HPMC) K4M, and Sodium Alginate were chosen for the development of in-situ gel. Formulation with Carbopol 940 and sodium alginate was optimized by assessing the gelling capacity. The prepared in-situ gel formulations were thoroughly characterized for gelling time, gelation temperature, Fourier-transform infrared (FTIR) spectroscopy studies, rheological study, sterility testing, corneal drug permeation, ocular irritation test, and accelerated stability study. Ex-vivo corneal permeation study was performed using goat cornea. The result of transcorneal permeation of acetazolamide followed the Fickian diffusion process. The optimized formulations showed satisfactory gelling time (4.17-5.17 sec) and dissolution time (120 min). FTIR study confirms the compatibility between the polymers and acetazolamide. The sterility study showed a satisfactory result. After 72 h observation in the in-vivo rabbit eye irritation study, the eyes appeared normal. There were no significant changes in pH and drug content in the accelerated stability studies of the formulations.

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Section: Ex-vivo Corneal Permeation Studymentioning

confidence: 99%

Formulation and evaluation of acetazolamide loaded in–situ gel for the treatment of glaucoma

ALI¹,

HABIBULLAH²,

GIRI³

et al. 2023

jrp

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Formulation and Assessment of Clay - Polymer Hydrogel Based on Georgian Bentonite

Tsiklauri

Getia

2023

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Bentonite clays are broadly employed in the design of varied drug delivery systems due to their characteristic feature such as adsorption, swelling ability and biocompatibility. Combination polymers with clay particles considerably improve mechanical and physical properties, drug -encapsulation efficiency and controlled release behavior of hybrids comparing with the starting components. One of the priority research areas at the I. Kutateladze Institute of Pharmacochemistry is extension the usage potential of Georgian bentonite clay in pharmacy, medicine, veterinary and cosmetics. Numerous semisolid dosage forms and dry ointments were proposed by the Institute on the bases of preparation Tikha Ascane, obtained from the clay of Askana Deposit (Ozurgeti region of Georgia).The aim of this study was to examine the suitability of Tikha Ascane as a substrate for the obtaining hybrid material with Sodium alginate (SA) and develop and characterize drug loaded clay/ polymer hydrogel Optimized formulation for Tikha Ascane/SA hybrids was selected and Nitrofurazone (NFZ) as a model drug was incorporated. The samples were characterized by examining FTIR spectra, morphology, viscosity, pH, homogeneity and appearance. Content of NFZ in hydrogel was determined by HPLC.FTIR analysis revealed that Tikha Ascane and SA act as a simply physical mixture. Infrared spectra showed that NFZ did not bind strongly to the hybrid material. Microscopic analyses allowed verification of homogeneity of samples. Optimal clay / polymer composites contained Tikha Ascane -SA at the ration of 1:3 (w/w) and 0.2 % w/w incorporated NFZ.From this work it is cleared that Georgian bentonite clay preparation -Tikha Ascane can be successfully used as a substrate for clay / polymer hybrid material; formulated complex exhibits promising characteristics that allows considering it as a potential drug delivery system. Further studies are on-going for the preparation of TA hybrid material with different polymers.

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Fabrication and Evaluation of Luliconazole contains Cationic Guar Gum intended to use for Topical application

Banerjee,

Sharma,

Padhy

et al. 2024

RJPT

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The novel imidazole topical drug luliconazole (LCZ) has potent antifungal efficacy against a wide variety of fungi. When applied to the skin, LCZ has tremendous promise as an antifungal agent, however, constrained by its poor skin permeability and limited solubility, requiring protracted therapy and repeated dosage to achieve full recovery. The current work explains the formulation and characterization of a cationic gel prepared by using Guar Gum (GG) and pH was adjusted by using NaOH solution. The created formulation was white in color. The FTIR spectroscopy analysis shows that the medication and polymer did not react with one another. The cumulative percentage drug release suggested that LCZ was released from the formulations. All the release kinetics show that drug release from the formulation was in Fickian transport nature. The correlation value was found to be more than 0.90 in all the fitted release models. The pH of each formulation fell within the predetermined range.The prepared LCZ gel shows a viscosity between 13000 to 28000 cps, which is a very good topical application.

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Bentonite increases the corneal permeation of the drug from the tamarind gum hydrogels

Cited by 3 publications

References 59 publications

Formulation and evaluation of acetazolamide loaded in–situ gel for the treatment of glaucoma

Formulation and evaluation of acetazolamide loaded in–situ gel for the treatment of glaucoma

Formulation and Assessment of Clay - Polymer Hydrogel Based on Georgian Bentonite

Fabrication and Evaluation of Luliconazole contains Cationic Guar Gum intended to use for Topical application

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