Benign Mixed Tumors (Pleomorphic Adenomas) of the Breast

Moran, César A.; Suster, Saul; Carter, Darryl

doi:10.1097/00000478-199010000-00003

Cited by 58 publications

(31 citation statements)

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“…CAM 5.2 also reacted with stromal cells in some tumours, an observation also reported for human breast lesions (39,46 . (44).…”

Section: Methodssupporting

confidence: 74%

“…As these cells were unreactive for a-actin, they have to be considered as entrapped epithelial remnants. Similar to observations in the benign canine mammary lesions, benign breast lesions in humans, e.g., intraductal papillomas, fibroadenomas and pleomorphic adenomas, contain elongated cells that are reactive with muscle-specific actin antibodies within the connective tissue of the tumours (4,39,43,44,53,63,66). Since actin antibodies also label myofibroblasts (25,52,53,56,62), and these stromal cells in the canine mammary lesions did not label with the keratin MoAbs known to label basal/myoepithelial cells, they may represent myofibroblasts rather than myoepithelial cells.…”

Section: Methodssupporting

confidence: 60%

“…The prominent presence of spindle-shaped, myoepithelial cells is considered to be characteristic of canine mammary neoplasms (34), although these cells have also been observed in feline and rat mammary tumours (24,50). In contrast to the situation with dogs, myoepithelial proliferations constitute only a minor component in human benign breast tumours (24) and pleomorphic adenomas, histomorphologically similar to canine mixed tumours (26), are rare in humans (3,4,14,39). In addition, tumour-like lesions, e.g., duct ectasias, can be found in mammary gland tissue (24).…”

Section: Immunohistochemistry With Keratin Vimentin Desmin and A-smentioning

confidence: 99%

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Immunohistochemistry with keratin, vimentin, desmin, and α‐smooth muscle actin monoclonal antibodies in canine mammary gland: Benign mammary tumours and duct ectasias

Vos

Ingh

Misdorp

et al. 1993

Veterinary Quarterly

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“…CAM 5.2 also reacted with stromal cells in some tumours, an observation also reported for human breast lesions (39,46 . (44).…”

Section: Methodssupporting

confidence: 74%

Section: Methodssupporting

confidence: 60%

Section: Immunohistochemistry With Keratin Vimentin Desmin and A-smentioning

confidence: 99%

See 1 more Smart Citation

Immunohistochemistry with keratin, vimentin, desmin, and α‐smooth muscle actin monoclonal antibodies in canine mammary gland: Benign mammary tumours and duct ectasias

Vos

Ingh

Misdorp

et al. 1993

Veterinary Quarterly

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“…All tumors showed a characteristic histological appearance with anastomosing cords of epithelial cells and abluminal cells, often with a reticular pattern and spread of these cells into the surrounding 'mesenchymal tissue' with mucoid/myxoid and/or chondroid differentiation ( Figure 1a and Supplementary Figure 1a). 9,[33][34][35] In three tumors (two parotid gland and one breast tumor), we found focal squamous cell metaplasia. Conventional immunohistochemical staining revealed a great variability (Table 1) and the dual nature of the tumors with epithelial and myoepithelial differentiation was confirmed.…”

Section: Pleomorphic Adenomasmentioning

confidence: 70%

K5/K14-positive cells contribute to salivary gland-like breast tumors with myoepithelial differentiation

et al. 2013

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Salivary gland-like tumors of the breast show a great variety of architectural patterns and cellular differentiations such as glandular, myoepithelial, squamous, and even mesenchymal phenotypes. However, currently little is known about the evolution and cellular differentiation of these tumors. For that reason, we performed an in situ triple immunofluorescence lineage/differentiation tracing (isTILT) and qRT-PCR study of basal (K5/K14), glandular (K7/K8/18), and epidermal-specific squamous (K10) keratins, p63, and smooth muscle actin (SMA; myoepithelial marker) with the aim to construct and trace different cell lineages and define their cellular hierarchy in tumors with myoepithelial differentiation. isTILT analysis of a series of 28 breast, salivary, and lacrimal gland tumors, including pleomorphic adenomas (n ¼ 8), epithelial-myoepithelial tumors (n ¼ 9), and adenoid cystic carcinomas (n ¼ 11) revealed that all tumor types contained K5/K14-positive progenitor cells in varying frequencies from a few percent up to 15%. These K5/K14-positive tumor cells were found to differentiate to glandular-(K8/18-positive) and myoepithelial-lineage (SMA-positive)-specific cells and were also shown to generate various heterologeous cell differentiations such as squamous and mesenchymal progenies. p63 was co-expressed with K5/K14 in basal-like progenitor cells, myoepithelial, and squamous cells but not in glandular cells. Our results show that the corresponding counterpart tumors of breast and salivary/lacrimal glands have identical cellular compositions. Taken together, our isTILT and RNA-expression data indicate that look-alike tumors of the breast represent a special subgroup of basal-type tumors with benign or usually low malignant potential.

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“…In fact, they were initially interpreted as intraductal papillomas with stromal metaplasia,' as biphasic, epithelial and mesenchymal, 4 or myoepithelial tumors, 2,3 as intraductal papillomas with myoepithelial proliferation, 5 or as epithelial tumors with a myoepithelial component. 6 Finally, in conjunction with their salivary counterparts, 19 ' 20 they have been regarded as monophasic epithelial neoplasms capable of divergent differentiation with a myoepithelial phenotype. 7 Other eccrine sweat gland-like breast tumors include syringomatous tumors.…”

mentioning

confidence: 99%

An Unusual, Recurring Breast Tumor With Features of Eccrine Spiradenoma:A Case Report

et al. 1996

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A n U n u s u a l , R e c u r r i n g B r e a s t T u m o r W i t h F e a t u r e s o f E c c r i n e S p i r a d e n o m a A Case ReportA new case of breast tumor with features of eccrine spiradenoma is described. This neoplasm is exceedingly rare, because only two cases, arising in breast parenchima, have been previously reported. The patient was a 43-year-old woman and she experienced three local recurrences at 7, 20, and 30 months from the first excision. No distant metastases were observed. Microscopically, the tumor was circumscribed and showed a lobulated pattern. Neoplastic lobules consisted of packed, monotonous, basaloid epithelial cells with round to ovoid nuclei and scant cytoplasm. At the periphery, the lobules were delimitated by smaller cells with dark nuclei.Immunohistochemical reactivity in tumoral cells was found for bothThe breast is a gland embryologically related to salivary and sweat glands; therefore, it is not surprising to note how breast tumors sometimes can show features of differentiation toward these structures. These tumors have to be considered true breast neoplasms with "divergent" differentiation and occur infrequently. Most often, they resemble mixed tumors (pleomorphic adenomas) of the salivary gland; 1 " 7 more rarely they share features of several eccrine sweat gland tumors such as syringomatous tumors, 8 " 12 or exceptionally eccrine spiradenoma 1314 and clear cell hidradenoma. 1415 Such lesions are usually regarded as benign, despite occasional local recurrences; 5710 however, they present difficulties in differential diagnosis. The new case reported below is of a locally aggressive and recurring breast tumor resembling an eccrine spiradenoma in a 43-year-old woman.CASE REPORT A 43-year-old woman presented in June 1993 with a 4-month history of a rapidly growing mass in her left breast, located in the areolar area. Address reprint requests to Prof. Guido Pettinato: Universita di Napoli Federico II, Istituto di Patologia, via S. Pansini 5, 80131, Napoli, Italia.cytokeratin and epithelial membrane antigen; vimentin, muscle-specific actin, glial fibrillary acidic protein, S-100 protein, and carcinoembryonal antigen were all negative. Furthermore, the lesion showed a diffuse positivity for estrogen and progesterone receptors and a high growth fraction labelled by MIB-1 (Ki-67) antibody. These findings, in conjunction with the deep location of the tumor, suggest an origin of the neoplasm from the breast epithelium. Because of a potential local aggressive behavior, the excision of a wide rim of uninvolved breast tissue is recommended. (Key words: Breast tumor; Eccrine spiradenoma; Immunohistochemistry; Steroid receptors; MIB-1) Am J Clin Pathol 1996;106:665-669.Clinical examination suggested a benign lesion and an excisional biopsy was performed.In January 1994, the patient noted two nodules in the scar area; mammography failed to reveal any infiltrating lesions or pathologic calcifications, and a fine-needle aspiration (FNA) cytologic examination indicated a recurrence of the ...

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Benign Mixed Tumors (Pleomorphic Adenomas) of the Breast

Cited by 58 publications

References 0 publications

Immunohistochemistry with keratin, vimentin, desmin, and α‐smooth muscle actin monoclonal antibodies in canine mammary gland: Benign mammary tumours and duct ectasias

Immunohistochemistry with keratin, vimentin, desmin, and α‐smooth muscle actin monoclonal antibodies in canine mammary gland: Benign mammary tumours and duct ectasias

K5/K14-positive cells contribute to salivary gland-like breast tumors with myoepithelial differentiation

An Unusual, Recurring Breast Tumor With Features of Eccrine Spiradenoma:A Case Report

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