An Unusual, Recurring Breast Tumor With Features of Eccrine Spiradenoma:<i>A Case Report</i>

Panico, Luigi; D’Antonio, Antonio; Chiacchio, Rosistella; Delrio, Paolo; Petrella, Giuseppe; Pettinato, Guido

doi:10.1093/ajcp/106.5.665

Cited by 14 publications

(6 citation statements)

References 6 publications

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“…The most common adnexal tumors occurring in the breast are mixed adnexal tumour and syringoma, which follow a benign clinical course in most cases. However cases of recurrent spiradenoma [ 8 ] and a carcinomasarcomatous eccrine spiradenoma [ 9 ] have been reported.…”

Section: Case Discussionmentioning

confidence: 99%

Cylindroma of the breast: a case report and review of the literature

Mahmoud

Hill

O’Sullivan

et al. 2009

Diagnostic Pathology

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Cylindroma of the breast is a very rare lesion which is morphological and immunophenotypically identical to benign dermal cylindroma. We report a breast cylindroma in a previously healthy 62 year old female detected through a national breast screening program. The patient had no significant family or past medical history, and specifically no history of breast or skin diseases. The tumor consisted of well circumscribed islands of epithelial cells surrounded by a dense membrane material, and focally containing hyaline globules. At low power the islands of tumour cells formed a "jig-saw" pattern, which is typical of cylindroma, but was present within normal breast parenchyma and no had direct connection with the overlying skin. Two distinct cell populations, smaller peripheral basaloid cells and larger central cells with vesicular chromatin, were highlighted by immunohistochemistry for p63 and cytokeratin-7 respectively. Immunohistochemistry for ER, PR, and Her2/neu was negative in tumour cells. We discuss the nine previously reported cases and the distinction of breast cylindroma from adenoid cystic carcinoma, the main differential diagnosis.

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Section: Case Discussionmentioning

confidence: 99%

Cylindroma of the breast: a case report and review of the literature

Mahmoud

Hill

O’Sullivan

et al. 2009

Diagnostic Pathology

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“…33 Spiradenomas of the breast have occasionally been reported. [34][35][36] None of the cases in the breast literature involved the nipple. However, 1 case presented with skin ulceration and contained areas of malignant transformation to spiradenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Basaloid Carcinoma of the Breast Mimicking Cutaneous Basaloid Neoplasms

Solus

Goyal²,

Duncan³

et al. 2015

The American Journal of Dermatopathology

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Basaloid carcinoma of the breast (BCB) is a rare, triple-negative aggressive primary breast tumor that can closely mimic cutaneous basal cell carcinoma (BCC), neuroendocrine tumors, adnexal neoplasms, and other primary breast tumors. Accurate diagnosis of this tumor is critical for appropriate clinical management. We add to the literature 2 female patients with BCB presenting with a nipple mass. Histopathologic findings from both patients showed dermal nests and cords of atypical basaloid cells with epidermal involvement, closely resembling cutaneous BCC. A panel of immunohistochemical stains, including the novel use of CK17, is essential for differentiating BCB from mimickers. BCB is a rare primary breast tumor that follows an aggressive clinical course and closely mimics many basaloid neoplasms, including cutaneous BCC clinicopathologically. Increased awareness of BCB among dermatologists and dermatopathologists is critical for accurate diagnosis and patient care.

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“…The characteristics of both tumors in all reported cases in the literature over the past 76 years are displayed in Table 1. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]…”

Section: Introductionmentioning

confidence: 99%

Spiradenoma of the breast and review of cases over 76-years

Dick

Sharma

2019

CRCP

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Spiradenomas stem from eccrine and apocrine glands to form benign cutaneous tumors. When arising on the breast, nipple, and areola region, spiradenomas can be difficult to differentiate from more worrisome breast masses. This is particularly true in patients with a prior history of breast cancer. These tumors can be mimicked by a wide range of adnexal growths and play a role in syndromic conditions. We present a case of a 56-year-old female with a 20-year enlarging left lower inner quadrant breast mass reviewed on mammography which was later excised and histopathologically diagnosed as a spiradenoma. Spiradenomas can be challenging to diagnose as they can present with similar findings on inexpensive and non-invasive testing such as ultrasound and mammogram. While a biopsy is a definitive tool for diagnosis, this is contraindicated in some spiradenoma mimickers such as epidermal cysts complicating diagnosis. To our knowledge, there are only six case reports of breast spiradenomas. We have reviewed the histopathology of this case and summarized all cases of breast spiradenomas and their malignant counterpart spiradenocarcinomas available in the literature compiling their presentations and imaging findings.

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An Unusual, Recurring Breast Tumor With Features of Eccrine Spiradenoma:A Case Report

Cited by 14 publications

References 6 publications

Cylindroma of the breast: a case report and review of the literature

Cylindroma of the breast: a case report and review of the literature

Basaloid Carcinoma of the Breast Mimicking Cutaneous Basaloid Neoplasms

Spiradenoma of the breast and review of cases over 76-years

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