Beneficial effects of β-Ecdysone on the joint, epiphyseal cartilage tissue and trabecular bone in ovariectomized rats

Kapur, Priya; Wuttke, W.; Jarry, Hubertus; Seidlová-Wuttke, Dana

doi:10.1016/j.phymed.2010.01.005

Cited by 67 publications

(61 citation statements)

References 42 publications

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“…Based on these spectroscopic data and comparison with spectral data in the literature (Son et al, 1999), the isolated compound was identified as 20-HES. It was previously reported that 20-HES, steroid found in invertebrates and plants, exhibited beneficial effects on joints, epiphyseal cartilage tissue, and trabecular bone in ovariectomized rats (Kapur et al, 2010;Swingler et al, 2009). Therefore, it was considered that 20-HES may be primarily responsible for prevention of collagenase-induced osteoarthritis in rabbits.…”

Section: Isolation Identification and Quantification Of 20-hes From mentioning

confidence: 99%

Anti-inflammatory and anti-osteoarthritis effects of fermented Achyranthes japonica Nakai

Lee

Park

et al. 2012

Journal of Ethnopharmacology

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Section: Isolation Identification and Quantification Of 20-hes From mentioning

confidence: 99%

Anti-inflammatory and anti-osteoarthritis effects of fermented Achyranthes japonica Nakai

Lee

Park

et al. 2012

Journal of Ethnopharmacology

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“…In addition, seeds of quinoa (Chenopodium quinoa Willd., Amaranthaceae), a functional food and nutraceutical, have very high contents of PEs (mainly 20E), 4-12 times more than spinach (Kumpun et al 2011), and compounds secreted by intact quinoa seeds into water during initial stages of germination reportedly have anti-diabetic properties, as they can significantly lower fasting blood glucose in obese, hyperglycemic mice (Graf et al 2014). Other therapeutic properties in mammals-including anabolic, performance-enhancing, anti-osteoporotic and wound healing effects-have also been described by various authors (e.g., Slama and Lafont 1995;Kapur et al 2010;Seidlova-Wuttke et al 2010;Syrov and Khushbaktova 1996;Lafont and Dinan 2003).…”

Section: Biological Importance Of Phytoecdysteroidsmentioning

confidence: 72%

Plant ecdysteroids: plant sterols with intriguing distributions, biological effects and relations to plant hormones

Tarkowská

Strnad

2016

Planta

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The present review summarises current knowledge of phytoecdysteroids' biosynthesis, distribution within plants, biological importance and relations to plant hormones. Plant ecdysteroids (phytoecdysteroids) are natural polyhydroxylated compounds that have a four-ringed skeleton, usually composed of either 27 carbon atoms or 28-29 carbon atoms (biosynthetically derived from cholesterol or other plant sterols, respectively). Their physiological roles in plants have not yet been confirmed and their occurrence is not universal. Nevertheless, they are present at high concentrations in various plant species, including commonly consumed vegetables, and have a broad spectrum of pharmacological and medicinal properties in mammals, including hepatoprotective and hypoglycaemic effects, and anabolic effects on skeletal muscle, without androgenic side-effects. Furthermore, phytoecdysteroids can enhance stress resistance by promoting vitality and enhancing physical performance; thus, they are considered adaptogens. This review summarises current knowledge of phytoecdysteroids' biosynthesis, distribution within plants, biological importance and relations to plant hormones.

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“…Achyranthes extracts are highly rich in bEcd [7]. The latter is reported to stimulate muscular growth in rodents [3,9,18] and increase the growth plate width in estrogen-deficient rats [24].…”

Section: Introductionmentioning

confidence: 99%

β-Ecdysone Augments Peak Bone Mass in Mice of Both Sexes

Dai

Zhang

Zhong

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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Background One of the strongest predictors for osteoporosis is peak bone mass. Interventions to augment peak bone mass have yet to be developed. b-Ecdysone (bEcd), a natural steroid-like compound produced by arthropods to initiate metamorphosis, is believed to have androgenic effects and so may be used to augment bone mass. Questions/purposes The purpose of this study was to use both male and female (1) gonadal-sufficient; and (2) -insufficient mice to investigate sex differences in terms of bone development and structure after bEcd administration.Methods Two-month-old male and female Swiss-Webster mice were randomized to receive either vehicle or bEcd (0.5 mg/kg) for 3 weeks. In a separate experiment to evaluate the effects of bEcd on sex hormone-deficient mice, gonadectomy was performed in male (orchiectomy [ORX]) and female mice (ovariectomy [OVX]). Shamoperated and the ORX/OVX mice were then treated for 3 weeks with bEcd. Primary endpoints for the study were trabecular bone structure and bone strength. Results In male mice, the trabecular bone volume was 0.18 ± 0.02 in the placebo-treated (PL) and 0.23 ± 0.02 in the bEcd-treated group (p \ 0.05 versus PL); and 0.09 ± 0.01 in the ORX group (p \ 0.05 versus PL) and 0.12 ± 0.01 in the ORX + bEcd group. Vertebral bone strength (maximum load) was 43 ± 2 in PL and 51 ± 1 in the bEcd-treated group (p \ 0.05 versus PL); and 30 ± 4 in the ORX group (p \ 0.05 versus PL) and 37 ± 3 in the ORX + bEcd group. In female mice, trabecular bone volume was 0.23 ± 0.02 in PL and 0.26 ± 0.02 in the bEcd-treated group (p \ 0.05 versus PL); and 0.15 ± 0.01 in the OVX group (p \ 0.05 versus PL) and 0.14 ± 0.01 in the OVX + bEcd group. Maximum load of the vertebrae was 45 ± 2 in PL and 48 ± 4 in the bEcd-treated group; and 39 ± 4 in the OVX group (p \ 0.05 versus PL) and 44 ± 4 in the OVX + bEcd group.

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Beneficial effects of β-Ecdysone on the joint, epiphyseal cartilage tissue and trabecular bone in ovariectomized rats

Cited by 67 publications

References 42 publications

Anti-inflammatory and anti-osteoarthritis effects of fermented Achyranthes japonica Nakai

Anti-inflammatory and anti-osteoarthritis effects of fermented Achyranthes japonica Nakai

Plant ecdysteroids: plant sterols with intriguing distributions, biological effects and relations to plant hormones

β-Ecdysone Augments Peak Bone Mass in Mice of Both Sexes

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