Plant ecdysteroids: plant sterols with intriguing distributions, biological effects and relations to plant hormones

Tarkowská, Danuše; Strnad, Miroslav

doi:10.1007/s00425-016-2561-z

Cited by 44 publications

(45 citation statements)

References 72 publications

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“…Here we demonstrate that the insect molting hormone ecdysone, which is the major ingredient of common adaptogens, possesses an aldosterone-like activity that is able to activate MR in vitro in aldosterone-responsive cells and in vivo in the kidney. As probably the most abundant steroids in nature, ecdysteroids are not only produced by arthropods but also widely exist in many plant species [4]. It has been popularly used as adaptogens or as anabolic compounds at high doses and for extended durations [6].…”

Section: Discussionmentioning

confidence: 99%

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Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities

Wang

Zhou

et al. 2018

Cell Physiol Biochem

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Background/Aims: Ecdysteroids are steroidal insect molting hormones that also exist in herbs. Ecdysteroid-containing adaptogens have been popularly used to improve well-being and by bodybuilders for muscle growth. However, the use of ecdysone in mammals is also associated with kidney growth and enlargement, indications of disturbed kidney homeostasis. The underlying pathogenic mechanism remains to be clarified. Methods: Virtual screening tools were employed to identify compounds that are homologous to ecdysone and to predict putative ecdysone-interacting proteins. The kidney effect of ecdysone was examined in vitro and in vivo and compared with that of aldosterone. Cellular apoptosis was estimated by terminal deoxynucleotidyl transferase dUTP nick end labeling. Cell motility was assessed by scratch-wound cell migration assay. Blood urea nitrogen was measured to evaluate renal function. Western immunblot analysis was employed to determine the expression profile of interested proteins. Results: Computational molecular structure analysis revealed that ecdysone is highly homologous to aldosterone. Moreover, virtual screening based on compound-protein interaction profiles identified the Mineralocorticoid Receptor (MR) to potentially interact with ecdysone. Accordingly, to assess potential biological functions of ecdysone in mammals, ecdysone was applied to mineralocorticoid-sensitive inner medullar collecting duct cells. Ecdysone induced mesenchymal accumulation of extracellular matrix and epithelial dedifferentiation characterized by de novo expression of α-smooth muscle actin. In addition, ecdysone elicited cellular apoptosis and retarded cell motility, akin to the effect of aldosterone. In vivo, daily treatment of mice with ecdysone increased cell apoptosis in the kidney, impaired renal function and elicited early signs of renal fibrogenesis, marked by deposition of collagen and fibronectin in tubulointerstitium, reminiscent of the action of aldosterone. The MR signaling pathway is likely responsible for the cellular and pathobiological effects of ecdysone, as evidenced by strong ecdysone-induced MR nuclear translocation in renal tubular cells both in vitro and in vivo, while blockade of MR by concomitant spironolactone treatment largely abolished the detrimental effects of ecdysone. Conclusion: Our findings suggest that ecdysone induces mineralocorticoid-dependent activities that impair renal function and elicit renal injury.

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Section: Discussionmentioning

confidence: 99%

“…So-called adaptogens can contain ecdysteroids -steroidal insect molting hormones that also exist in herbs [2][3][4][5]. Ecdysteroid-containing adaptogens have been popularly used for improving well-being and by bodybuilders for muscle growth [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities

Wang

Zhou

et al. 2018

Cell Physiol Biochem

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“…Вообще, холестерин может синтезироваться многими животными и растениями [Tarkowská, Strnad, 2016], однако интересно, что насеко-мые неспособны синтезировать холестерин de novo и должны потреблять экзогенные стеро-иды для его синтеза [Clark, Block, 1959;.…”

Section: особенности биосинтеза стероидных гормонов у костистых рыбunclassified

Some Aspects of Steroid Regulation in Teleosts

Rendakov

2018

Proceedings of KarRC of RAS

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“…The most compelling hypothesis, for which there is some evidence (Mondy et al . ; Tarkowská & Strnad ) is that they have a role in defence against generalist phytophagous invertebrate predators.…”

Section: Structure and Physiologymentioning

confidence: 99%

Biological Flora of the British Isles: Serratula tinctoria

Jefferson

Walker

2017

Journal of Ecology

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Summary This account presents information on all aspects of the biology of Serratula tinctoria L. that are relevant to understanding its ecological characteristics and behaviour. The main topics are presented within the standard framework of the Biological Flora of the British Isles: distribution, habitat, communities, responses to biotic factors, responses to environment, structure and physiology, phenology, floral and seed characters, herbivores and disease, history and conservation. Serratula tinctoria is a gynodioecious perennial forb of open or semi‐shaded habitats including grassland, heath, mire, open woodland and scrub and their ecotones. It is found throughout most of England and Wales but it is very rare in Scotland and absent from Ireland. Serratula tinctoria is found in Europe as far north as southern Sweden and Norway. It is absent from much of the Boreal biogeographical zone, including most of Fennoscandia and northern Poland, Russia and the Baltic States, and from the lowland Mediterranean zone. Serratula tinctoria occurs on soils overlying a wide variety of superficial deposits and sedimentary, metamorphic and igneous rocks, including ultramafic rocks. The pH range of these soils is wide, ranging from acidic to moderately alkaline but with nutrient status classed as oligotrophic, or more rarely mesotrophic. In mire or fen habitats, it occurs in topogenous or soligenous situations with a similar soil water pH range. It is able to tolerate a wide spectrum of soil water‐table conditions, ranging from very dry to flooded. Serratula tinctoria is pollinated by various insects of the orders Hymenoptera, Diptera and Lepidoptera, particularly bumblebees, hoverflies and butterflies. It produces phytoecdysteroids, which mimic a hormone that regulates insect development. The seed has a feathery pappus for wind dispersal and establishment is primarily from seed. However, it has strong dispersal limitation with slow migration rates into restored grasslands of 1 m year−1. The species has a short‐term persistent seed bank. Seedling recruitment is enhanced by disturbance that creates bare ground, increasing light flux and lower cover of bryophytes and litter, and reduced by higher nutrient availability and lack of management. Formerly the source of a yellow dye, S. tinctoria has declined in Britain since at least the late 19th Century primarily due to a combination of drainage, ploughing and agricultural improvement and, conversely, lack of management by cutting and grazing in its grassland, heath and mire habitats. There is evidence that the decline slowed or stabilised between the late‐1980s and the mid‐2000s, in part due to the positive impact of conservation via statutory protection on designated sites and wider measures delivered through agri‐environment schemes.

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Plant ecdysteroids: plant sterols with intriguing distributions, biological effects and relations to plant hormones

Cited by 44 publications

References 72 publications

Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities

Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities

Some Aspects of Steroid Regulation in Teleosts

Biological Flora of the British Isles: Serratula tinctoria

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