Beneficial effects of the extract from Corydalis yanhusuo in rats with heart failure following myocardial infarction

Abstract

As indicated in ancient Chinese medical books, Corydalis yanhusuo has therapeutic effects on cardiovascular diseases. The analgesic effect of this plant has been fully elucidated, and l-tetrahydropalmatine has been shown to be the main active principle. The aim of this investigation was to evaluate its protective effects in a rat heart failure model. Rats were subjected to coronary artery ligation, and orally administered with ethanolic extract of Corydalis yanhusuo 50, 100, or 200 mg kg(-1) daily, from the 7th day after surgery. We measured cardiac function, plasma atrial natriuretic peptide (ANP), relative heart and lung weights, infarct size and ventricular dilatation after treatment for 8 weeks. Administration with Corydalis yanhusuo led to a significant reduction in infarct size and improvement in cardiac function as demonstrated by lower left ventricular end diastolic pressure (LVEDP) and elevated +/-dp/dt(max). We also found that Corydalis yanhusuo significantly reduced left ventricular (LV)/body weight ratio, lung/body weight ratio and significantly inhibited neurohormonal activation. Taken together, this study indicated that Corydalis yanhusuo exerted salutary effects on heart failure induced by myocardial infarction in rats.

Simultaneous screening and analysis of antiplatelet aggregation active alkaloids from Rhizoma Corydalis

“…Various pharmacological effects of Rhizoma Corydalis, such as antioxidant, anticancer, pain relief and promotion of blood circulation were reported (Leung et al 2003;Wu et al 2007;Wang et al 2010). The use of Rhizoma Corydalis for promoting blood circulation to treat cardiovascular disease associated with thrombosis has gained increasing attention ).…”

“…Dehydrocorydaline can increase platelet cyclic adenosine monophosphate (cAMP) level and also can inhibit the release of adenosine diphosphate (ADP)-induced platelet factor 4 (PF4) and the generation of thromboxane A 2 (TXA 2 ) significantly (Yang et al 1989;Guo et al 2000). However, compared to the wide applications of Rhizoma Corydalis alkaloids in the treatment of cardiovascular diseases (Ling et al 2006;Wu et al 2007), the research on its active antithrombotic components is still very limited.…”

Differential proteomic analysis of platelets suggested target-related proteins in rabbit platelets treated with Rhizoma Corydalis

“…Differential proteomic analysis of platelets suggested target-related proteins in rabbit platelets treated with Rhizoma Corydalis Wu (Papaveraceae), has a wide range of pharmacological activities such as promotion of blood circulation, antioxidant, alleviating pain, inhibition proliferation of cancer cell, antiulcer, antihypertension and vasorelaxant (Leung et al 2003;Wu et al 2007;Gao et al 2009;Wang et al 2010;Qu et al 2015). The function of improving the blood circulation to treat thrombosis associated cardiovascular diseases of RC became increasingly attractive.…”

Characterization of Corydalis (Papaveraceae s. l.) and Dioscorea (Dioscoreaceae) Species: 1. Root Anatomical Characters

“…The tissues of some contain sapogenin precursors of cortisone and other steroids (Martin & Ortiz, 1963), and dried tubers of Corydalis have been used for treatments of hypersensitivity, arrhythmia, dysmenorrhea, dyspepsia, rheumatism, and ulcers, etc. (Sagare et al, 2000;Wu et al, 2007;Henkes et al, 2011;Ji et al, 2012).…”