Beneficial effects of quercetin–iron complexes on serum and tissue lipids and redox status in obese rats

Imessaoudene, Asmahan; Merzouk, Hafida; Berroukeche, Farid; Mokhtari-Soulimane, Nassima; Bensenane, Bachir; Cherrak, Sabri; Merzouk, Sid Ahmed; Elhabiri, Mourad

doi:10.1016/j.jnutbio.2015.11.011

Cited by 26 publications

(9 citation statements)

References 54 publications

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“…A previous study showed that rats fed with a cafeteria diet and supplemented with quercetin – another flavonoid – exhibited an improvement in redox state by increasing the activity of antioxidant enzymes such as CAT and reduced glutathione (GSH) and decreasing the formation of ROS (anion superoxide and nitric oxide) and lipid peroxidation (MDA formation and carbonylation of proteins). 42 This is in agreement with our results showing that GH supplementation given alone reduced lipid peroxidation. It is suggestive that, in some pathological conditions, exogenous administration of antioxidants may be of interest to protect cells and organs against the increased production of ROS and impaired endogenous antioxidant defense.…”

Section: Discussionsupporting

confidence: 93%

Effects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet

Gonçalves¹,

Lázaro²,

Mateo³

et al. 2018

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ObjectiveThe aim of the study was to evaluate the effects of supplementation with glucosyl hesperidin (GH), with or without physical training, on body weight, fat depot, glucose and plasma lipids, oxidative status and vascular function of rats fed with high-fat diet (HFD).MethodsAfter weaning, male Wistar rats were fed with an HFD plus fructose for 12 weeks and started receiving oral antioxidant supplementation and/or physical training after the fourth week of diet for eight further weeks. Body weight, epididymal and retroperitoneal fat, plasma glucose and lipids, oxidative status and mesenteric artery reactivity were evaluated.ResultsRats fed with HFD presented higher body weight gain and fat accumulation compared to control rats, while GH supplementation did not influence these parameters. Physical training reduced the body weight gain and fat accumulation and modulated the oxidative status by increasing superoxide dismutase activity and total antioxidant capacity and reducing lipid peroxidation. GH alone decreased lipid peroxidation. However, when given to exercised rats, it impaired the response elicited by physical training. HFD caused endothelial dysfunction, and neither GH nor physical exercise prevented it. Potency of sodium nitroprusside was increased in exercised animals but not in GH-supplemented rats.ConclusionPhysical exercise partially decreased the body fat accumulation, decreased plasma levels of glucose and lipids and improved general oxidative status and endothelium-independent relaxation in mesenteric arteries of rats fed with HFD. GH exhibited benefits only in the oxidative status. However, GH given in association with physical exercise did not cause further changes in addition to those promoted by physical exercise. On the contrary, in exercised animals, GH prevented those changes elicited by physical training in plasma glucose and lipids, oxidative status and endothelium-independent relaxation.

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Section: Discussionsupporting

confidence: 93%

Effects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet

Gonçalves¹,

Lázaro²,

Mateo³

et al. 2018

DMSO

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“…As such, one study demonstrated that, while purified polyphenols decreased the iron parameters in the subjects, ingestion of polyphenols in context with iron significantly improved the iron and redox status in vivo. 38…”

Section: Nutritional Iron Uptakementioning

confidence: 99%

Linking iron-deficiency with allergy: role of molecular allergens and the microbiome

et al. 2017

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Atopic individuals tend to develop a Th2 dominant immune response, resulting in hyperresponsiveness to harmless antigens, termed allergens. In the last decade, epidemiological studies have emerged that connected allergy with a deficient iron-status. Immune activation under iron-deficient conditions results in the expansion of Th2-, but not Th1 cells, can induce class-switching in B-cells and hampers the proper activation of M2, but not M1 macrophages. Moreover, many allergens, in particular with the lipocalin and lipocalin-like folds, seem to be capable of binding iron indirectly via siderophores harboring catechol moieties. The resulting locally restricted iron-deficiency may then lead during immune activation to the generation of Th2-cells and thus prepare for allergic sensitization. Moreover, iron-chelators seem to also influence clinical reactivity: mast cells accumulate iron before degranulation and seem to respond differently depending on the type of the encountered siderophore. Whereas deferoxamine triggers degranulation of connective tissue-type mast cells, catechol-based siderophores reduce activation and degranulation and improve clinical symptoms. Considering the complex interplay of iron, siderophores and immune molecules, it remains to be determined whether iron-deficiencies are the cause or the result of allergy.

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“…The excess production of ROS with insufficient antioxidant enzymes in obese children may have a serious adverse effect on red blood cell membranes, resulting in lipid peroxidation enhancing production of MDA concentrations [20]. In another article, it was observed that erythrocyte glutathione (GSH) levels and catalase activity were reduced and MDA levels were enhanced in obese rats when compared to controls [50]. Amirkhizi and colleagues hypothesized that obesity is an independent risk factor for lipid peroxidation and decreased activity of cytoprotective enzymes in humans.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it was demonstrated that treatments with either quercetin or quercetin-iron complexes alleviated oxidative stress in obese rats, by reducing oxidant markers and increasing antioxidant defense. This elevation in antioxidants may be due to the neutralization of ROS as quercetin has been found to scavenge superoxide anions and other free radicals in vitro [50].…”

Section: Discussionmentioning

confidence: 99%

Effects of Green Apple (Golden Delicious) and Its Three Major Flavonols Consumption on Obesity, Lipids, and Oxidative Stress in Obese Rats

Aksoy

Ötleş

2022

Molecules

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Obesity is becoming increasingly common all over the world and global strategies are accordingly being developed to prevent it. In order to support the strategies, the effects of green apple (Golden Delicious) and the consumption of its three major flavonols (quercetin-3-glucoside, quercetin-3-D-galactoside, and quercetin-3-rhamnoside) on body weight; the weight of liver, kidney, and spleen; some lipid parameters in serum; and total lipid ratios of liver and kidney and oxidative stress parameters of obese rats were studied. This study was conducted on two experimental groups: one of which was given an apple, and the other was given flavonols, in addition to their high-energy diet; along with a sham and a control rat group, for 4 weeks. According to results, there was no difference in body and organ weights between groups. The liver and kidney weights increased in obese rats, but there was no difference between the total lipid ratios in these organs. The addition of green apple and selected flavonols to the high-energy diet of rats was not sufficient to prevent the increase in body and organ weights, but it supported the reduction in some lipid fractions and in oxidative stress parameters of obese rats. Moreover, this study supported the argument that obesity causes most of the lipid fractions increase in serum and induces oxidative stress.

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Beneficial effects of quercetin–iron complexes on serum and tissue lipids and redox status in obese rats

Cited by 26 publications

References 54 publications

Effects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet

Effects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet

Linking iron-deficiency with allergy: role of molecular allergens and the microbiome

Effects of Green Apple (Golden Delicious) and Its Three Major Flavonols Consumption on Obesity, Lipids, and Oxidative Stress in Obese Rats

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