Effects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet

Gonçalves, Tiago Tomazini; Lázaro, Carolina Martins; Mateo, Fernanda G. De; Campos, Marcela C.B.; Mezencio, Jackeline; Claudino, Mário A.; Carvalho, Patrícia de Oliveira; Webb, R.; Priviero, Fernanda

doi:10.2147/dmso.s153661

Cited by 7 publications

(5 citation statements)

References 51 publications

(58 reference statements)

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“…This suggests a similar effect of both molecules in preventing the physiological changes produced by detraining. In addition, hesperidin (0.5 mmol·kg −1 of body mass) intake has been shown to be effective in reducing the accumulation of body fat mass, glucose levels and blood lipids in rats fed a high-fat diet [ 57 ]. The possible pathways used by chronic intake of 2S-hesperidin to decrease physiological changes derived from detraining would be related to the modulating gene components, such as AMPK and PGC-1α [ 15 , 47 , 48 ], which control energy production, utilization of metabolic substrates (fats and carbohydrates), mitochondrial biogenesis and oxidative capacity [ 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of 8 Weeks of 2S-Hesperidin Supplementation on Performance in Amateur Cyclists

2020

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2S-Hesperidin is a flavanone (flavonoid) found in high concentrations in citrus fruits. It has an antioxidant and anti-inflammatory effects, improving performance in animals. This study investigated the effects of chronic intake of an orange extract (2S-hesperidin) or placebo on non-oxidative/glycolytic and oxidative metabolism markers and performance markers in amateur cyclists. A double-blind, randomized, placebo-controlled trial was carried out between late September and December 2018. Forty amateur cyclists were randomized into two groups: one taking 500 mg/day 2S-hesperidin and the other taking 500 mg/day placebo (microcellulose) for eight weeks. All participants completed the study. An incremental test was used to evaluate performance, and a step test was used to measure oxygen consumption, carbon dioxide, efficiency and oxidation of carbohydrates and fat by indirect calorimetry. The anaerobic power (non-oxidative) was determined using Wingate tests (30 s). After eight weeks supplementation, there was an increase in the incremental test in estimated functional threshold power (FTP) (3.2%; p ≤ 0.05) and maximum power (2.7%; p ≤ 0.05) with 2S-hesperdin compared to placebo. In the step test, there was a decrease in VO2 (L/min) (−8.3%; p ≤ 0.01) and VO2R (mL/kg/min) (−8.9%; p ≤ 0.01) at VT2 in placebo. However, there were no differences between groups. In the Wingate test, there was a significant increase (p ≤ 0.05) in peak and relative power in both groups, but without differences between groups. Supplementation with an orange extract (2S-hesperdin) 500 mg/day improves estimated FTP and maximum power performance in amateur cyclists.

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Section: Discussionmentioning

confidence: 99%

Effects of 8 Weeks of 2S-Hesperidin Supplementation on Performance in Amateur Cyclists

2020

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“…The SFO-HF and TFO-HF groups were exposed to HF diets commercially purchased (20.27% carbohydrates, 19.89% protein, and 59.38% lipids, totaling 5.20 Kcal/g) (Prag solutions R , Biosciences, Jau, Brazil) and overload of 200 mL of soft drink per week (100% carbohydrates -21 g, sodium:10 mg totaling 0.85 Kcal/g), and with free access to water after the 21st day of birth, during 6 months. Previous studies showed the efficacy of this HF diet on body weight gain, adipose tissue weight gain in Wistar rats (Thalita et al, 2014;Goncalves et al, 2018). The use o soft drinks for rats is a complement and characterization of the HF diet, besides it's an effective strategy for an increase the total energy intake and body mass over time.…”

Section: Offspring Dietmentioning

confidence: 95%

Paternal Resistance Training Modulates Calcaneal Tendon Proteome in the Offspring Exposed to High-Fat Diet

Neto

Tibana

Silva

et al. 2020

Front. Cell Dev. Biol.

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The increase in high-energy dietary intakes is a well-known risk factor for many diseases, and can also negatively impact the tendon. Ancestral lifestyle can mitigate the metabolic harmful effects of offspring exposed to high-fat diet (HF). However, the influence of paternal exercise on molecular pathways associated to offspring tendon remodeling remains to be determined. We investigated the effects of 8 weeks of paternal resistance training (RT) on offspring tendon proteome exposed to standard diet or HF diet. Wistar rats were randomly divided into two groups: sedentary fathers and trained fathers (8 weeks, three times per week, with 8-12 dynamic movements per climb in a stair climbing apparatus). The offspring were obtained by mating with sedentary females. Upon weaning, male offspring were divided into four groups (five animals per group): offspring from sedentary fathers were exposed either to control diet (SFO-C), or to high-fat diet (SFO-HF); offspring from trained fathers were exposed to control diet (TFO-C) or to a high-fat diet (TFO-HF). The Nano-LC-MS/MS analysis revealed 383 regulated proteins among offspring groups. HF diet induced a decrease of abundance in tendon proteins related to extracellular matrix organization, transport, immune response and translation. On the other hand, the changes in the offspring tendon proteome in response to paternal RT were more pronounced when the offspring were exposed to HF diet, resulting in positive regulation of proteins essential for the maintenance of tendon integrity. Most of the modulated proteins are associated to biological pathways related to tendon protection and damage recovery, such as extracellular matrix organization and

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“…Some studies have demonstrated the efficacy of this HFD model in body weight gain and adiposity in Wistar rats ( Goncalves et al, 2018 ; de Sousa Neto et al, 2020b ). Soft drinks for rats are used as a complement and characterization of the HF diet and are an effective strategy to promote the increase in total energy intake and body weight gain in the long term ( Messier et al, 2007 ; Lozano et al, 2016 ).…”

Section: Methodsmentioning

confidence: 99%

Paternal Resistance Exercise Modulates Skeletal Muscle Remodeling Pathways in Fathers and Male Offspring Submitted to a High-Fat Diet

et al. 2021

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Although some studies have shown that a high-fat diet (HFD) adversely affects muscle extracellular matrix remodeling, the mechanisms involved in muscle trophism, inflammation, and adipogenesis have not been fully investigated. Thus, we investigated the effects of 8 weeks of paternal resistance training (RT) on gene and protein expression/activity of critical factors involved in muscle inflammation and remodeling of fathers and offspring (offspring exposed to standard chow or HFD). Animals were randomly distributed to constitute sedentary fathers (SF; n = 7; did not perform RT) or trained fathers (TF n = 7; performed RT), with offspring from mating with sedentary females. After birth, 28 male pups were divided into four groups (n = 7 per group): offspring from sedentary father submitted either to control diet (SFO-C) or high-fat diet (SFO-HF) and offspring from trained father submitted to control diet (TFO-C) or high-fat diet (TFO-HF). Our results show that an HFD downregulated collagen mRNA levels and upregulated inflammatory and atrophy pathways and adipogenic transcription factor mRNA levels in offspring gastrocnemius muscle. In contrast, paternal RT increased MMP-2 activity and decreased IL-6 levels in offspring exposed to a control diet. Paternal RT upregulated P70s6k and Ppara mRNA levels and downregulated Atrogin1 mRNA levels, while decreasing NFκ-B, IL-1β, and IL-8 protein levels in offspring exposed to an HFD. Paternal physical training influences key skeletal muscle remodeling pathways and inflammatory profiles relevant for muscle homeostasis maintenance in offspring submitted to different diets.

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Effects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet

Cited by 7 publications

References 51 publications

Effects of 8 Weeks of 2S-Hesperidin Supplementation on Performance in Amateur Cyclists

Effects of 8 Weeks of 2S-Hesperidin Supplementation on Performance in Amateur Cyclists

Paternal Resistance Training Modulates Calcaneal Tendon Proteome in the Offspring Exposed to High-Fat Diet

Paternal Resistance Exercise Modulates Skeletal Muscle Remodeling Pathways in Fathers and Male Offspring Submitted to a High-Fat Diet

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