Beneficial Effects of Intravenous Administration of Lipo-Prostaglandin E1 on the Ischemic Gastric Tube in Pigs

Tobari, Shoichi; Ikeda, Yoshifumi; Takami, Hiroshi

doi:10.1016/j.jss.2005.05.021

Cited by 9 publications

(7 citation statements)

References 24 publications

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“…This coating protects PGE1 from being rapidly metabolized 12 . In our previous study, 13 TBF on ischemic site of the gastric tube after lipo‐PGE1 administration was significantly increased and maintained over 10 mL/min/100 g until 10 minutes after the end of administration. In this article, we investigate how long the beneficial effects of intravenous administration of lipo‐PGE1 on the ischemic gastric tube continue.…”

Section: Introductionmentioning

confidence: 82%

Long beneficial effects after lipo-prostaglandin E1 administration on the ischemic gastric tube in pigs

Ikeda

Morita

2008

Diseases of the Esophagus

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Lipo-prostaglandin E1 (PGE1) is a new preparation of PGE1 in which it is bound to lipids in order to slow PGE1 release and delay its rate of metabolism. We investigated how long the beneficial effects of intravenous administration of lipo-PGE1 on the ischemic gastric tube continue. The gastric tube was constructed using 15 domestic pigs under general anesthesia and saline, unmodified PGE1 and lipo-PGE1 were infused continuously at a rate of 0.05 microg/kg/min for 10 minutes. Tissue blood flow (TBF) was analyzed from before administration to 120 minutes after the end of administration. There were no obvious changes in TBF during the administration of saline. However, TBF during treatment with unmodified PGE1 and lipo-PGE1 was significantly increased to 13.1 +/- 1.3 and 13.5 +/- 1.4 mL/min/100 g, respectively (paired t-test; P < 0.01). Although TBF was significantly decreased to 8.0 +/- 1.0 mL/min/100 g on 10 minutes after the end of unmodified PGE1 administration (paired t-test; P < 0.01), it was maintained over 10 mL/min/100 g until 120 minutes in lipo-PGE1 group. Lipo-PGE1 infusion leads to the objectively measurable improvement and the prolonged action in the blood perfusion of the gastric tube in pigs.

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Section: Introductionmentioning

confidence: 82%

Long beneficial effects after lipo-prostaglandin E1 administration on the ischemic gastric tube in pigs

Ikeda

Morita

2008

Diseases of the Esophagus

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“…Some researchers have coated PGE 1 in lipid microspheres (lipo-PGE 1 ) to protect it from rapid metabolism in the lungs and give fewer side-effects. 20 Nishimura et al 17 showed no obvious differences between the effects of PGE 1 and lipo-PGE 1 on systematic blood pressure and cochlear blood flow, so our meta-analysis combined studies on PGE 1 and lipo-PGE 1 .…”

Section: Discussionmentioning

confidence: 98%

Is the Application of Prostaglandin E₁ Effective for the Treatment of Sudden Hearing Loss? An Evidence-based Meta-analysis

Zhuo

Wang

et al. 2008

J Int Med Res

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Microvascular dysfunction in the cochlea has been considered the major cause of sudden hearing loss (SHL). For some time, prostaglandin E 1 (PGE 1 ), an effective vasodilator, has been used to treat patients with SHL, however the benefits of this therapy remain unclear. The present study assessed the efficacy of PGE 1 on SHL via a quantitative meta-analysis of 13 randomized controlled studies. The pooled odds ratio was 1.95 (95% confidence interval: 1.53, 2.50) and the test for overall effect (Z-value) was 5.31 (P < 0.00001), suggesting that PGE 1 is an effective and promising strategy for the treatment of SHL.

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“…Lipo‐PGE 1 was developed with one of these approaches as a targeting‐type drug delivery system. This approach was shown to be effective to deliver a sufficient amount of PGE 1 to the lesional site,12,14,15 and thus, several commercial products of PGE 1 are currently available as solutions of lipo‐PGE 1. However, it should be noted that the pharmacological potency of lipo‐PGE 1 varies significantly depending on which clinical solution the original lipo‐PGE 1 solution is mixed with.…”

Section: Discussionmentioning

confidence: 99%

“…PGE 1 is dissolved into the o/w lipid emulsion containing these lipid microspheres, and then it is spontaneously incorporated by the microspheres because of its lipophilicity 12,13. It was demonstrated that the lipid microspheres effectively carry PGE 1 to the vascular lesion site, and that lipo‐PGE 1 exerts a more potent pharmacological effect than free PGE 1 12,14,15…”

Section: Introductionmentioning

confidence: 99%

Alteration of Therapeutic Efficacy of Lipid Microspheres Incorporating Prostaglandin E1 by Mixing with Aqueous Solution

Komori

Aiba

Kushima

et al. 2007

Journal of Pharmaceutical Sciences

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Beneficial Effects of Intravenous Administration of Lipo-Prostaglandin E1 on the Ischemic Gastric Tube in Pigs

Cited by 9 publications

References 24 publications

Long beneficial effects after lipo-prostaglandin E1 administration on the ischemic gastric tube in pigs

Long beneficial effects after lipo-prostaglandin E1 administration on the ischemic gastric tube in pigs

Is the Application of Prostaglandin E₁ Effective for the Treatment of Sudden Hearing Loss? An Evidence-based Meta-analysis

Alteration of Therapeutic Efficacy of Lipid Microspheres Incorporating Prostaglandin E1 by Mixing with Aqueous Solution

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Beneficial Effects of Intravenous Administration of Lipo-Prostaglandin E1 on the Ischemic Gastric Tube in Pigs

Cited by 9 publications

References 24 publications

Long beneficial effects after lipo-prostaglandin E1 administration on the ischemic gastric tube in pigs

Long beneficial effects after lipo-prostaglandin E1 administration on the ischemic gastric tube in pigs

Is the Application of Prostaglandin E1 Effective for the Treatment of Sudden Hearing Loss? An Evidence-based Meta-analysis

Alteration of Therapeutic Efficacy of Lipid Microspheres Incorporating Prostaglandin E1 by Mixing with Aqueous Solution

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Is the Application of Prostaglandin E₁ Effective for the Treatment of Sudden Hearing Loss? An Evidence-based Meta-analysis