Beneficial effect of zinc supplementation on biomechanical properties of femoral distal end and femoral diaphysis of male rats chronically exposed to cadmium

Brzóska, Małgorzata M.; Gałażyn-Sidorczuk, Małgorzata; Rogalska, Joanna; Roszczenko, Alicja; Jurczuk, M.; Majewska, Katarzyna; Moniuszko-Jakoniuk, J

doi:10.1016/j.cbi.2007.11.007

Cited by 45 publications

(42 citation statements)

References 42 publications

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“…Osteotoxicity of Cd is well documented and could be at least partly explained by the interactions between Cd and bioelements in bones (37,38). However, under our experimental conditions, the applied Cd dose of 10 mg kg -1 bw did not induce significant changes in the Cu and Mg content, although a significant decrease was achieved for Zn (43).…”

Section: Bulat Z Et Al Can Zinc Supplementation Ameliorate Cadmium-mentioning

confidence: 51%

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Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

Bulat

Đukić-Ćosić²,

Antonijević³

et al. 2017

Archives of Industrial Hygiene and Toxicology

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The study was designed to investigate the influence of zinc (Zn) supplementation on cadmium-induced alterations in zinc, copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of cadmium (Cd), Zn, Cu, and Mg were estimated in the blood, liver, kidney, and bone. The rabbits were divided in a control group, a Cd group-animals intoxicated orally with Cd (10 mg kg -1 bw, as aqueous solution of Cd-chloride), and a Cd+Zn group-animals intoxicated with the same dose of Cd and co-treated with Zn (20 mg kg -1 bw, as aqueous solution of Zn-sulphate). Solutions were administered orally, every day for 28 days. Sample mineralisation was performed with concentrated nitric acid (HNO 3 ) and perchloric acid (HClO 4 ) (4:1) and metal concentrations were determined by atomic absorption spectrophotometry (AAS). Zinc supplementation improved some of Cd-induced disturbances in bioelement levels in the investigated tissues. Beneficial effects of Zn on Zn and Cu levels were observed in blood, as well as on the Cu kidney level. The calculated values for Cu/Zn, Mg/Zn, and Mg/Cu ratios in blood suggest that Zn co-treatment reduces Cd-induced changes in bioelement ratios in blood.

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Section: Bulat Z Et Al Can Zinc Supplementation Ameliorate Cadmium-mentioning

confidence: 51%

“…This was explained by Zn and Cd competition for transport proteins DMT1 and ZnT1 (28,36). Furthermore, Zn supplementation lowered the risk of bone fractures, and increased bone density and biochemical bone properties in animals intoxicated with Cd for six months (37,38). A beneficial, i.e.…”

mentioning

confidence: 99%

Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

Bulat

Đukić-Ćosić²,

Antonijević³

et al. 2017

Archives of Industrial Hygiene and Toxicology

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“…At both levels of exposure, the impact of Cd on the strength of the femur was clearly evident only after the 17-month and longer intoxication. As it was reported in details in our previous papers, the weakening of the biomechanical properties of the femur due to the treatment with Cd results from the unfavourable impact of this heavy metal on the mineral status and organic matrix (formed mainly by collagen) of the bone [15][16][17][18]33,34]. Proper amount and structure of collagen fibers play an important role for bone formation and strength [29,30,35].…”

Section: Discussionmentioning

confidence: 94%

“…The results of the present study show that the low exposure to Cd (1 mg Cd/kg diet) inhibited collagen biosynthesis in the bone tissue already after 10 months. Because the impact of Cd on the "structural" and "material" biomechanical properties of the femoral diaphysis and the femoral neck susceptibility to fracture was previously reported by us [15][16][17][18]33] and the mechanisms leading to an increase in the bone susceptibility to fracture are known and reported therefore they are not discussed in the present paper. However, the very important finding of the present study regarding the impact of Cd on the femur susceptibility to fracture is revealing that this heavy metal may weaken biomechanical properties of the femoral neck and diaphysis at the exposure lower than it has been revealed until now [16,18].…”

Section: Discussionmentioning

confidence: 96%

Protective Effect of Chokeberry (<em>Aronia melanocarpa </em>L.) Extract Against Cadmium Impact on the Biomechanical Properties of the Femur: A Study in a Rat Model of Low and Moderate Lifetime Women Exposure to this Heavy Metal

Brzóska

Roszczenko

Rogalska

et al. 2017

Preprint

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The hypothesis that consumption of Aronia melanocarpa berries (chokeberries) extract, recently reported by us to improve bone metabolism in female rats at low-level and moderate chronic exposure to cadmium (1 and 5 mg Cd/kg diet for up to 24 months), may increase the bone resistance to fracture was investigated. Biomechanical properties of the neck (bending test with vertical head loading) and diaphysis (three-point bending test) of the femur of rats administered 0.1% aqueous chokeberry extract (65.74% of polyphenols) or/and Cd in the diet (1 and 5 mg Cd/kg) for 3, 10, 17, and 24 months were evaluated. Moreover, procollagen I was assayed in the bone tissue. The low-level and moderate exposure to Cd decreased procollagen I concentration in the bone tissue and weakened biomechanical properties of the femoral neck and diaphysis. Chokeberry extract administration under the exposure to Cd improved the bone collagen biosynthesis and femur biomechanical properties. The results allow for the conclusion that consumption of chokeberry products under exposure to Cd may improve the bone biomechanical properties and protect from fracture. This study provides support for Aronia melanocarpa berries being a promising natural agent for the skeleton protection under low-level and moderate chronic exposure to Cd.

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“…Literature data indicate the protective role of Zn supplementation against Cd toxicity, possibly because it stimulates metallothionein synthesis and competes with Cd for enzyme-binding sites (14,67,(76)(77)(78). In addition, some studies have shown favourable effects of pretreatment with other essential elements on Cd toxicity (79,80).…”

Section: Therapy Of Cadmium Poisoningmentioning

confidence: 99%

Cadmium Toxicity Revisited: Focus on Oxidative Stress Induction and Interactions with Zinc and Magnesium

Matović

Buha

Bulat

et al. 2011

Archives of Industrial Hygiene and Toxicology

179

122

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Discovered in late 1817, cadmium is currently one of the most important occupational and environmental pollutants. It is associated with renal, neurological, skeletal and other toxic effects, including reproductive toxicity, genotoxicity, and carcinogenicity. There is still much to fi nd out about its mechanisms of action, biomarkers of critical effects, and ways to reduce health risks. At present, there is no clinically effi cient agent to treat cadmium poisoning due to predominantly intracellular location of cadmium ions. This article gives a brief review of cadmium-induced oxidative stress and its interactions with essential elements zinc and magnesium as relevant mechanisms of cadmium toxicity. It draws on available literature data and our own results, which indicate that dietary supplementation of either essential element has benefi cial effect under condition of cadmium exposure. We have also tackled the reasons why magnesium addition prevails over zinc and discussed the protective role of magnesium during cadmium exposure. These fi ndings could help to solve the problem of prophylaxis and therapy of increased cadmium body burden.

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Beneficial effect of zinc supplementation on biomechanical properties of femoral distal end and femoral diaphysis of male rats chronically exposed to cadmium

Cited by 45 publications

References 42 publications

Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

Protective Effect of Chokeberry (<em>Aronia melanocarpa </em>L.) Extract Against Cadmium Impact on the Biomechanical Properties of the Femur: A Study in a Rat Model of Low and Moderate Lifetime Women Exposure to this Heavy Metal

Cadmium Toxicity Revisited: Focus on Oxidative Stress Induction and Interactions with Zinc and Magnesium

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