Beneficial effect of local injury to the endometrium in intracytoplasmic sperm injection (ICSI) patients with recurrent implantation failure

Buzzi, P.J.; Zappacosta, M.P.; Auge, L.; Isa, Lokman Md; Obejero, E. Young; Bello, A.

doi:10.1016/j.fertnstert.2014.07.997

Cited by 2 publications

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“…Unlike the routine IVF-ET technology, following the ICSI-ET protocol, a single normal sperm was placed in a fine needle under a microscope using external force, followed by piercing of the zona pellucida and the egg membrane with the needle tip and injection of the sperm into the follicle pulp to complete fertilization. In this process of fertilization, the invasive procedure can create some unfavorable conditions that may impact the implantation of the embryos and change the endometrial microenvironment, which can affect the health of the offspring ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Correlation of hypertensive disorders in pregnancy with procedures of in vitro fertilization and pregnancy outcomes

Xiong¹,

Hu²,

Zhang³

et al. 2017

Exp Ther Med

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We investigated the correlation of hypertensive disorders in pregnancy with different procedures of in vitro fertilization, and analyzed pregnancy outcomes of patients with hypertensive disorders in pregnancy. A retrospective analysis was performed on the medical records of 658 maternity patients who conceived through in vitro fertilization in Maternal and Child Health Hospital of Wuxi. Patients were divided into two groups according to different fertilization procedures: i) the routine in vitro fertilization-embryo transfer group (IVF-ET group, 377 cases) and ii) intra-cytoplasmic sperm injection-embryo transfer group (ICSI-ET group, 281 cases). Consequently, patients were further divided into two groups according to different embryo transfer cycles: the fresh embryo transfer group (F-ET group, 446 cases) and the frozen-thawed embryo transfer group (T-ET group, 212 cases). Characteristics of patients in each group were evaluated, and incidence of hypertensive disorders in pregnancy resulting from different assisted reproductive technology was compared. Among patients who conceived through IVF, there were 56 cases of hypertensive disorders in pregnancy, including 21 cases of gestational hypertension, 34 cases of pre-eclampsia and 1 case of eclampsia. The odds ratio (OR) of gestational hypertension in the comparison between the ICSI-ET and IVF-ET groups was 2.01 (0.81–4.74), and was reduced to 1.69 (0.70–4.02) after correction. The difference of OR in twin-birth patients of the two groups was statistically significant, but the difference in single-birth patients was not statistically significant. The odds ratio (OR) of gestational hypertension in the comparison between the F-ET and T-ET groups was 0.44 (0.13–1.34), and became 0.49 (0.15–1.51) after correction. The odds ratio of pre-eclampsia in the comparison between the ICSI-ET and IVF-ET groups was 1.36 (0.42–4.18), and was reduced to 1.17 (0.36–3.62) after correction. The odds ratio of pre-eclampsia in the comparison between the F-ET and T-ET groups was 0.93 (0.42–1.96), and became 0.98 (0.44–2.12) after correction. The differences were not statistically significant. The risk of onset of hypertensive disorders in pregnancy has a certain correlation with the ICSI fertilization technology, but has no apparent correlation with embryo transfer cycles.

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Section: Discussionmentioning

confidence: 99%

Correlation of hypertensive disorders in pregnancy with procedures of in vitro fertilization and pregnancy outcomes

Xiong¹,

Hu²,

Zhang³

et al. 2017

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…Multiple pregnancy often increase uterine pressure to an unusually high level, which cause severe placental ischemia and hypoxia, resulting in vascular endothelial cell damage and dysfunction [6]. Not only multiple pregnancy, but the assisted therapy method also play an important role in the maternal and neonatal outcome, following the ICSI-ET(intro-cytoplasmic sperm injection and embryo transplantation) process, the invasive procedure can create some unfavorable condition that may impact the implantation of the embryos and change the endometrial microenvironment, which can affect the health of the off springs [7].…”

Section: Introductionmentioning

confidence: 99%

How Many Embryos Should Be Transplanted After IVF Having Previous Pre-Eclampsia: A Case Report

Han¹,

Xuelan²

2018

JGO

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Pre-eclampsia is a pregnancy-induced hypertensive disorder which affect multiple organ functions, it is one of the main factors increasing the morbidity and mortality of the maternal and neonatal. Furthermore, with the increasing rate of infertility or sub-fertility, more and more couples are conceiving assisted reproductive therapies, especially in vitro fertilization (IVF), which brings high possibility of multiple pregnancy due to its unique process and the patients demands. As is well known that multiple pregnancy may face great challenges of complications such as pre-eclampsia, gestational diabetes, intrahepatic cholestasis of pregnancy etc. If pre-eclampsia is not treated and monitored very well on time the mothers perhaps will have eclampsia, placental abruption or multiple organ dysfunction leading to death, likewise those fetus whose mother suffered from Pre-eclampsia also face the risks of fetus growth restriction, fetal stress or even stillbirth. We represent a patient in our clinic who had done twice in vitro fertilization-embryo transplantation(IVF-ET) with several high risks of pre-eclampsia and followed by recurrent Pre-eclampsia and Intrahepatic Cholestasis of Pregnancy, we fully recognize her risks in her second pregnancy and give a close antenatal surveillance, and she finally have two alive babies, but a large amount of money was spend for the two preterm babies in hospitalization in NICU and also the mother herself became exhausted and almost lost her hope. It reminds us that before conceiving IVF technology for patients, the indication must be clear, the adverse effect must be brought into consideration, cooperation must be obtained from both the reproductive clinicians and obstetrician to fully balance the benefit and adverse effect, attention must be paid to choose the best method during the assisted reproductive therapies and acquire the utmost benefit and avoid the side effect as possible.

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Beneficial effect of local injury to the endometrium in intracytoplasmic sperm injection (ICSI) patients with recurrent implantation failure

Cited by 2 publications

References 0 publications

Correlation of hypertensive disorders in pregnancy with procedures of in vitro fertilization and pregnancy outcomes

Correlation of hypertensive disorders in pregnancy with procedures of in vitro fertilization and pregnancy outcomes

How Many Embryos Should Be Transplanted After IVF Having Previous Pre-Eclampsia: A Case Report

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