How Many Embryos Should Be Transplanted After IVF Having Previous Pre-Eclampsia: A Case Report

Abstract

Pre-eclampsia is a pregnancy-induced hypertensive disorder which affect multiple organ functions, it is one of the main factors increasing the morbidity and mortality of the maternal and neonatal. Furthermore, with the increasing rate of infertility or sub-fertility, more and more couples are conceiving assisted reproductive therapies, especially in vitro fertilization (IVF), which brings high possibility of multiple pregnancy due to its unique process and the patients demands. As is well known that multiple pregnancy may face great challenges of complications such as pre-eclampsia, gestational diabetes, intrahepatic cholestasis of pregnancy etc. If pre-eclampsia is not treated and monitored very well on time the mothers perhaps will have eclampsia, placental abruption or multiple organ dysfunction leading to death, likewise those fetus whose mother suffered from Pre-eclampsia also face the risks of fetus growth restriction, fetal stress or even stillbirth. We represent a patient in our clinic who had done twice in vitro fertilization-embryo transplantation(IVF-ET) with several high risks of pre-eclampsia and followed by recurrent Pre-eclampsia and Intrahepatic Cholestasis of Pregnancy, we fully recognize her risks in her second pregnancy and give a close antenatal surveillance, and she finally have two alive babies, but a large amount of money was spend for the two preterm babies in hospitalization in NICU and also the mother herself became exhausted and almost lost her hope. It reminds us that before conceiving IVF technology for patients, the indication must be clear, the adverse effect must be brought into consideration, cooperation must be obtained from both the reproductive clinicians and obstetrician to fully balance the benefit and adverse effect, attention must be paid to choose the best method during the assisted reproductive therapies and acquire the utmost benefit and avoid the side effect as possible.