Correlation of hypertensive disorders in pregnancy with procedures of in vitro fertilization and pregnancy outcomes

Xiong, Fang; Hu, Lingqing; Zhang, Yun; Xiao, Xiao

doi:10.3892/etm.2017.5204

Cited by 9 publications

(11 citation statements)

References 23 publications

(22 reference statements)

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“…Therefore, the existing literature and research concluded that the early, middle and late stages of placental development exhibit distinct differences in physiological functions and gene expression, and understanding the effects of pathogenic factors on early placental development, function and gene expression contributes to early diagnosis and medical intervention (34). a growing body of evidence supports the hypothesis that various adverse pregnancy outcomes observed after arT originate from suboptimal placentation caused by abnormal trophoblast function (2,3). in humans, after adjusting for several confounding factors, the risk of spontaneous abortion is higher in arT cohorts than for spontaneous pregnancies (35).…”

Section: Discussionmentioning

confidence: 99%

“…There is currently growing interest in the potential risks associated with assisted reproductive technology (arT). after adjusting for several confounding factors, the risk of numerous adverse outcomes during the perinatal period, including miscarriage, premature birth, low birth weight, intra-uterine growth retardation and gestational hypertension, are higher in in vitro fertilization and embryo transfer (iVF-eT) cohorts than for spontaneous pregnancies (1)(2)(3). over the last few years, the early stages of mammalian embryonic development have been shown to be very sensitive to the microenvironment, with long term effects on fetal, postnatal and adult health (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

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In�vitro fertilization and embryo transfer alter human placental function through trophoblasts in early pregnancy

et al. 2020

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The mechanism underlying the potential risk associated with in vitro fertilization and embryo transfer (iVF-eT) has been previously investigated but remains to be fully elucidated. as the placenta is a critical organ that sustains and protects the fetus, this is an important area of research. The aim of the present study was to determine the difference in trophoblast cell function in the first trimester between naturally conceived pregnancies and pregnancies achieved via iVF-eT therapy. a total of 20 placental villi in first trimester samples were obtained through fetal bud aspiration from patients undergoing iVF-eT due to oviductal factors between January 2016 and august 2018. in addition, a further 20 placental villi were obtained from those who naturally conceived and had normal pregnancies but were undergoing artificial abortion; these patients were recruited as the controls. reverse transcription-quantitative (rT-q)Pcr and semi-quantitative immunohistochemical methods were used to detect the mrna and protein expression of α-fetoprotein (aFP), vascular endothelial growth factor (VeGF), transferrin (TF), tubulin β1 class Vi (TuBB1), metallothionein 1G (MT1G), Bcl2, glial cells missing transcription factor 1 (GcM1), epidermal growth factor (eGF) receptor (eGFr), PTen and leukocyte associated immunoglobulin like receptor 2 (lair2) in villi from both groups. differentially expressed genes were analyzed using Search Tool for the retrieval of interacting Genes, and Kyoto encyclopedia of Genes and Genomes (KeGG) pathway analysis was conducted. The rT-qPcr data revealed that the mRNA expression levels of AFP, VEGF and TF were significantly higher in the iVF-eT group than in the control group (P<0.05), and those of TuBB1, MT1G, Bcl2, GcM1, eGFr, PTEN and LAIR2 were significantly lower (P<0.05). These gene products were expressed in the placental villus tissues, either in the cytoplasm, or in the membrane of syncytiotrophoblast and cytotrophoblast cells. The immunohistochemistry results were in line with those observed using rT-qPcr. KeGG pathway analysis indicated that the trophoblast cell function of the IVF-ET group in the first trimester was different from naturally conceived pregnancies with regard to proliferation, invasion, apoptosis and vascular development. The iVF-eT process may trigger adaptive placental responses, and these compensatory mechanisms could be a risk for certain diseases later in life.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In�vitro fertilization and embryo transfer alter human placental function through trophoblasts in early pregnancy

et al. 2020

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“…In common with singleton pregnancies, twin pregnancies complicated by PE are at greater risk of an adverse pregnancy outcome 43 .In contrast with our findings, some studies suggest that IVF is significantly associated with a higher incidence of PE. Also,severe PE was more prevalent in the singleton IVF-PE group than in the singleton SC-PE group [44][45][46] .…”

Section: Discussionmentioning

confidence: 91%

Incidence and risk factors for preeclampsia in a cohort of high-risk pregnant women: a nested case-control study from South India

Madhavan¹,

Pal²,

Pal³

et al. 2020

Preprint

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Objective: To explore the incidence and risk factors of preeclampsia (PE) among high-risk pregnant women in South India. Design: Nested case-control study Setting: Tertiary referral hospital Population or Sample: Pregnant women with risk for PE. Methods: Maternal characteristics were prospectively collected, and risk factors were assessed comparatively between women with risk for developing PE and normotensive pregnant women using risk ratio (RR) (95% CI) plus multivariate analysis. One hundred and seventy-four risk group pregnant women were followed-up once in each trimester till delivery and noted for the development of PE. Main Outcome Measures: Incidence and risk factors of PE among high-risk pregnant women. Results: 67/174 women developed PE, corresponding to an incidence of 38.51% among pregnant women with risk for PE. Women in the age group of 30 and older reported a higher incidence. Maternal factors like absence of a family history of chronic hypertension, history of abortion, non-consanguineous marriage, and AB blood group were significant protective factor and sex of the newborn being female was a significant risk factor for developing PE. Conclusion: This is the first Indian study that explored the incidence and risk factors for PE among high-risk pregnant women. Incidence of PE was higher among South Indian risk population. Female infants significantly contributed to the PE risk.

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“…In a study by Xiong et al, in 2017, the authors stated that the risk of gestational hypertension in pregnancy has a certain correlation with the ICSI fertilization technology [ 20 ]. In addition, many studies supported in their results that ART pregnancy has been reported as a factor linked to an increased risk for hypertension [ [21] , [22] , [23] , [24] ].…”

Section: Discussionmentioning

confidence: 99%

The practice of intracytoplasmic sperm injection in Jordan: A clinical outcome study

Altal

Aleshawi

Khrais

et al. 2020

Annals of Medicine and Surgery

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Objective The lack of appropriate guidelines and justified practice in most developing countries is a serious limitation to efforts to qualify the services provided. In this paper, we evaluate and assess the clinical practice of an assisted reproductive technique of intracytoplasmic sperm injection (ICSI) in Jordan. Methods Retrospectively, we identified women who achieved a successful pregnancy by ICSI over a period of ten years. Information related to the ICSI procedure, foetus abnormalities, maternal complications and delivery outcomes were included. A control group of normal pregnancies were incorporated. Results In total, 291 cases were included as successful cases of ICSI with a success rate of 14.1%. For the control group, 466 pregnant women with normal pregnancies were included. No statistical difference was observed between both groups in foetus malformation. In normal pregnancy women, 42.1% delivered through caesarean section (CS) while 87.6% of ICSI patients underwent CS. Women with ICSI had significantly higher rates of multiple gestations, and their neonates were lower in birthweight. Women in the ICSI group tended to deliver females compared to the control group. Pregnancy-related hypertension was more commonly reported in the normal pregnancy group, while gestational diabetes, antepartum haemorrhage and preterm labour were more common in ICSI group. Conclusion Services for the management of infertility are increasing in the Middle East. The clinical outcomes in Jordan is approaching that of other developed regions, although the success rate is lower than in other regions. Further studies and efforts should be carried out to maximize effective and successful practice in such low-income areas.

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Correlation of hypertensive disorders in pregnancy with procedures of in vitro fertilization and pregnancy outcomes

Cited by 9 publications

References 23 publications

In�vitro fertilization and embryo transfer alter human placental function through trophoblasts in early pregnancy

In�vitro fertilization and embryo transfer alter human placental function through trophoblasts in early pregnancy

Incidence and risk factors for preeclampsia in a cohort of high-risk pregnant women: a nested case-control study from South India

The practice of intracytoplasmic sperm injection in Jordan: A clinical outcome study

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