Beiträge zur Frage der Herz- und Gelenkveränderungen bei Gelenkrheumatismus und Scharlach

Fahr, Th.

doi:10.1007/bf01943217

Cited by 56 publications

(4 citation statements)

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“…Nevertheless, Fahr (26) has found changes in the capsule of the knee of patients succumbing to rheumatic fever which he states are in every way comparable to the myocardial lesions. Coombs (27) makes a similar statement concerning the shoulder joint of one patient. Lately, we have examined portions of the capsule of the knee or ankle at the acute stages of rheumatic arthritis, and found focal lesions of the synovia, focal necrosis of the capsule, thrombosis of the smaller arteries, and endothelial and perivascular reactions comparable with changes found in the heart and in subcutaneous nodules (Figs.…”

Section: Histopathology Of Joint Lesionsmentioning

confidence: 71%

A Study on Rheumatic Fever

Ali¹

2019

jmscr

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This paper briefly describes about the RHEUMATIC FEVER. It is apparent that there are two particular sorts of reaction with respect to the body to the infectious operator of rheumatic fever; through, proliferative and exudative. The perivascular proliferative kind of sore, taking after an irresistible granuloma, clarifies the subacute and constant character of the clinical indications in numerous patients with this illness. The complex clinical indications of rheumatic fever have been the reason for much perplexity in our origination of the basic idea of the ailment. Another purpose behind this perplexity is the way that such a large number of maladies now and again have joint agonies as a piece of their side effect complex.

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Section: Histopathology Of Joint Lesionsmentioning

confidence: 71%

A Study on Rheumatic Fever

Ali¹

2019

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Section: Histopathology Of Joint Lesionsmentioning

confidence: 98%

“…Doubtless comparable lesions in other organs or tissues are not infrequently present (26,29), but are not detected either because they fail to give rise to symptoms or because the usual well marked manifestations of the disease outweigh them in prominence.…”

Section: Correlation Of Symptoms and Histopathological Lesions Of Rhementioning

confidence: 99%

The Pathogenesis of Rheumatic Fever

Swift

1924

Journal of Experimental Medicine

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It is evident that there are two distinct types of response on the part of the body to the infectious agent of rheumatic fever; viz., proliferative and exudative. The perivascular proliferative type of lesion, resembling an infectious granuloma, explains the subacute and chronic character of the clinical symptoms in many patients with this disease. Marked exudation of serum into the periarticular tissues and of serum and cells into the joint cavities are concomitants of the acute arthritis occurring with high fever and general intoxication; these acute exudations disappear following the administration of certain drugs. But their disappearance does not mean necessarily that all lesions of the proliferative type have resolved. In fact, we know that these last mentioned lesions, when present in the subcutaneous tissues, often continue for months; and from analogy we may conclude that they have a similar persistent character in other tissues of the body invaded by the causative agent of rheumatic fever.

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“…The Aschoff body was considered by Klinge and by most subsequent authorities as a granulomatous reaction to altered fibrinoid collagen. The vascular changes in this disease comprise principally fibrinoid degeneration and necrotizing inflammation of small and medium sized vessels (18,(31)(32)(33)(34).…”

Section: Gala Globulin In Auricular Appendagesmentioning

confidence: 99%

Immunologic Studies of Heart Tissue

Kaplan¹,

Dallenbach²

1961

The Journal of Experimental Medicine

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PLATES 1 TO 4(Received for publication, July 20, 1960.)The present work gives evidence by use of fluorescent antibody methods of deposits of bound gamma globulin with characteristic histologic distribution in the auricular appendages of certain patients with rheumatic heart disease. These deposits were not associated with Aschoff lesions; they occurred in spotty distribution throughout the myocardium, involving myofibers, and to a lesser extent, connective tissue and vessel walls. Other proteins, i.e., albumin and fibrinogen, were absent from these foci. Furthermore, the tissue sites demonstrating fixation of gamma globulin frequently exhibited evidences of alteration as indicated by affinity for eosin and intense reactivity with the periodic acidSchiff stain. Bound gamma globulin with associated histochemical change was observed in a significant proportion of rheumatic hearts, but not in normal or pathologic control tissues.In previous studies of rheumatic hearts, Vazquez and Dixon (1) described in fixed tissue sections gamma globulin in altered perivascular connective tissue and in Aschoff lesions. According to the authors, "it was not possible to show a difference between the amount of gamma globulin visualized specifically within the fibrinoid necrosis of the Aschoff bodies and in the immediate

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Beiträge zur Frage der Herz- und Gelenkveränderungen bei Gelenkrheumatismus und Scharlach

Cited by 56 publications

References 0 publications

A Study on Rheumatic Fever

A Study on Rheumatic Fever

The Pathogenesis of Rheumatic Fever

Immunologic Studies of Heart Tissue

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