Behavioral and Neurobiological Convergence of Odor, Mood and Emotion: A Review

Kontaris, Ioannis; East, Brett S.; Wilson, Donald A.

doi:10.3389/fnbeh.2020.00035

Cited by 72 publications

(52 citation statements)

References 163 publications

(213 reference statements)

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“…The crucial role of the olfactory pathway in brain respiratory-drive is today largely recognized, and particularly well emphasized in review papers 2,[45][46][47][48] . But credit where credit is due: in their excellent opinion paper, Fontanini and Bower 49 were the first in 2006 to clearly posit that " […] it might be that the pan-cortical correlations that particularly characterize slow-wave sleep and meditation actually depend on an afferent input signal generated within the olfactory system."…”

Section: Discussionmentioning

confidence: 99%

The deep and slow breathing characterizing rest favors brain respiratory-drive

Girin

Juventin

Garcia

et al. 2020

Preprint

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A respiration-locked activity in the olfactory brain, mainly originating in the mechano-sensitivity of olfactory sensory neurons to air pressure, propagates from the olfactory bulb to the rest of the brain. Interestingly, changes in nasal airflow rate result in reorganization of olfactory bulb response. Therefore, if the respiratory drive of the brain originates in nasal airflow movements, then it should vary with respiration dynamics that occur spontaneously during natural conditions. We took advantage of the spontaneous variations of respiration dynamics during the different waking and sleep states to explore respiratory drive in various brain regions. We analyzed their local field potential activity relative to respiratory signal. We showed that respiration regime was state-specific, and that quiet waking was the only vigilance state during which all the recorded structures can be respiration-driven whatever the respiration frequency. We used a CO2-enriched air to change the respiratory regime associated to each state and, using a respiratory cycle-by-cycle analysis, we evidenced that the large and strong brain entrainment during quiet waking was the consequence of its associated respiration regime consisting in an optimal trade-off between deepness and duration of inspiration. These results show for the first time that changes in respiration regime alter the cortical dynamics and that the respiratory regime associated with rest is optimal for respiration to drive the brain.

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Section: Discussionmentioning

confidence: 99%

The deep and slow breathing characterizing rest favors brain respiratory-drive

Girin

Juventin

Garcia

et al. 2020

Preprint

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“…Motivational deficits in SCZ are most likely associated with cortico-striatal circuits involving the VTA, and the ventral striatum ( Aberg et al., 2020 ; Kontaris et al., 2020 ). Clinical observation keep suggesting some involvement of ventral striatum in the control of motivation, emotions and social behavior as relevant for negative symptoms in SCZ with regular debates on the matter ( Fareri et al., 2017 ; Stepien et al., 2018 ; Waltz et al., 2018 ).…”

Section: Section 2: Dr Alterations In Schizophreniamentioning

confidence: 99%

Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia

Martel¹,

McArthur²

2020

Front. Pharmacol.

169

125

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Dopamine receptors are widely distributed within the brain where they play critical modulator roles on motor functions, motivation and drive, as well as cognition. The identification of five genes coding for different dopamine receptor subtypes, pharmacologically grouped as D1- (D1 and D5) or D2-like (D2S, D2L, D3, and D4) has allowed the demonstration of differential receptor function in specific neurocircuits. Recent observation on dopamine receptor signaling point at dopamine—glutamate-NMDA neurobiology as the most relevant in schizophrenia and for the development of new therapies. Progress in the chemistry of D1- and D2-like receptor ligands (agonists, antagonists, and partial agonists) has provided more selective compounds possibly able to target the dopamine receptors homo and heterodimers and address different schizophrenia symptoms. Moreover, an extensive evaluation of the functional effect of these agents on dopamine receptor coupling and intracellular signaling highlights important differences that could also result in highly differentiated clinical pharmacology. The review summarizes the recent advances in the field, addressing the relevance of emerging new targets in schizophrenia in particular in relation to the dopamine – glutamate NMDA systems interactions.

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“…Affective states are understood as bipolar constructs currently experienced by an individual in response to a direct or indirect interpretation or appraisal of events and stimuli. It is the combination of emotions and moods ( Kontaris et al, 2020 ). Emotion is a more intense mental state than mood, related to physiological responses.…”

Section: Introductionmentioning

confidence: 99%

Subjective Rank of the Competition as a Factor Differentiating Between the Affective States of Swimmers and Their Sport Performance

2020

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PurposeThe aim of the study was to establish the differences in affective states of swimmers depending on the subjective rank of the competition and the relationship between affective states and performance in sports competitions of low, medium and high subjectively perceived rank.MethodsThe respondents (n = 31) aged from 15 to 23 years (18.1 ± 2.397) were studied using the psychological questionnaires Perceived Stress Scale (PSS-10), Profile of Mood State (POMS), and Positive and Negative Affect Schedule (PANAS) during sports events. 362 measurements using POMS and 232 measurements using PANAS before the starts were collected. The significance of intergroup differences was determined using the Kruskal-Wallis test. A stepwise regression analysis was used to determine the emotional predictors of sports results.ResultsSubjective rank of sports competition differentiated significantly anger (chi2 = 6.826; p = 0.033), confusion (chi2 = 11.345; p = 0.003), depression (chi2 = 10.2; p = 0.006), fatigue (chi2 = 49.394; p ≤ 0.001), vigour (chi2 = 11.345; p ≤ 0.001), positive emotions (chi2 = 51.233; p ≤ 0.001), and negative emotions (chi2 = 11.552; p = 0.003). Regression analysis showed the influence of mood states and positive emotions on the sports result.ConclusionThe swimmers’ affective state changed depending on the subjective rank of the competition. Depression and positive emotional state made it possible to predict the result in medium- and high-rank competition.

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Behavioral and Neurobiological Convergence of Odor, Mood and Emotion: A Review

Cited by 72 publications

References 163 publications

The deep and slow breathing characterizing rest favors brain respiratory-drive

The deep and slow breathing characterizing rest favors brain respiratory-drive

Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia

Subjective Rank of the Competition as a Factor Differentiating Between the Affective States of Swimmers and Their Sport Performance

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