Behavior of cultured human umbilical vein endothelial cells on titanium oxide films fabricated by plasma immersion ion implantation and deposition

Chen, J.Y; Wan, Guo Jiang; Leng, Y.X.; Yang, Ping; Sun, Hong; Wang, J; Huang, Nan

doi:10.1016/j.surfcoat.2004.02.050

Cited by 38 publications

(11 citation statements)

References 16 publications

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“…titanium and Ti-6Al-4V alloy, which improve the low hardness of the substrate alloy [34,35]. Even though the adherence and growth of cultured HUVEC on titanium oxide films fabricated by plasma immersion ion implantation and deposition has already been studied [36], there have not yet been, to our knowledge, studies in which the possible effects of titanium alloys on some aspects of cellular and molecular biology of cultured HUVEC are reported.…”

Section: Introductionmentioning

confidence: 99%

Effects of surface treatment of Ti–6Al–4V titanium alloy on biocompatibility in cultured human umbilical vein endothelial cells

et al. 2005

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Section: Introductionmentioning

confidence: 99%

Effects of surface treatment of Ti–6Al–4V titanium alloy on biocompatibility in cultured human umbilical vein endothelial cells

et al. 2005

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“…10,11 Many cell lines have been demonstrated to be suitable for assessing the biocompatibility of titanium alloys as well as other biomaterials. [12][13][14][15][16][17][18][19][20][21] In order to verify the biocompatibility of metal implants, blood cells have been also extensively used. Human mononuclear cells cultured on degradable poly(urethane urea), polystyrene and titanium in vitro were tested by Gretzer et al 22 for adhesion, apoptosis, and cytokine release.…”

Section: Introductionmentioning

confidence: 99%

In vitro interaction between surface‐treated Ti‐6Al‐4V titanium alloy and human peripheral blood mononuclear cells

Martinesi

Bruni

Stio

et al. 2005

J Biomedical Materials Res

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The Ti-6Al-4V titanium alloy is widely employed as an implant material. The effects of Ti-6Al-4V samples, tested in both an untreated state and one in which the samples were subjected to a glow-discharge treatment performed with the use of air, on human peripheral blood mononuclear cells (PBMC) were studied. Apoptosis, undetectable after 24-h contact of PBMC with the two sample types, is induced after 48 h by treated samples, and, after 48 h, but in the presence of 1.5 microg/mL PHA, by both sample types. The expression of intercellular adhesion molecule-1 (ICAM-1) always increases, in comparison with control, in PBMC put in contact with the two sample types. In the same way, a remarkable increase in tumor necrosis-alpha (TNF-alpha) release in the culture medium is registered, when PBMC are put in contact with the two sample types for 24 and 48 h. Human umbilical-vein endothelial cells (HUVEC) cocultured for 48 h with PBMC, previously incubated with the two sample types for 24 h, show an increase in ICAM-1 and vascular cell adhesion molecule-1 (VCAM-1) protein expression in comparison with control (HUVEC cocultured with control PBMC), indicating that inflammatory phenomena might occur. Taken together, these results suggest that, although plasma-treated titanium alloy shows a better biocompatibility in comparison with the untreated one, attention must be paid to the careful control of the first signs of inflammation.

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“…The surfaces 1#, 2#, 3# and NiTi alloy samples were immersed in a cell solution containing ECGF in M199 culture medium [6]. All EC incubations were carried out at 37uC in a humidified atmosphere containing 95% air and 5% CO 2 for 1, 3 and 5 days.…”

Section: Biological Investigation Of Huvecsmentioning

confidence: 99%

Effect of micro-characterization on thrombus formation ability of TiO2 film

Jiang

Chen

Huang

2008

Front. Mater. Sci. China

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The thrombus formation ability of a biomedical microcoil for hemangioma treatment is one of the basic requirements in clinical intervention application. Surface modification of a biomedical microcoil can improve its thrombus formation ability. In this work, TiO 2 films were deposited using the unbalanced magnetron sputtering method. The structures, components and micro-morphologies of the films were investigated by Xray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), atomic force microscope (AFM), and scanning electron microscope (SEM). The thrombus formation ability of the films was studied by in vitro platelet adhesion test. The results indicated that a certain characteristic TiO 2 film has the ability to increase thrombus formation. Furthermore, the biological behavior of cultured human umbilical vein endothelial cells (HUVECs) onto different films was investigated by an in vitro HUVECs cultured experiment. The results showed that endothelial cells on certain TiO 2 film surfaces have good adherence, growth and proliferation. Additionally, the relationship between the micro-characterization and biological properties of TiO 2 films is discussed.

show abstract

Behavior of cultured human umbilical vein endothelial cells on titanium oxide films fabricated by plasma immersion ion implantation and deposition

Cited by 38 publications

References 16 publications

Effects of surface treatment of Ti–6Al–4V titanium alloy on biocompatibility in cultured human umbilical vein endothelial cells

Effects of surface treatment of Ti–6Al–4V titanium alloy on biocompatibility in cultured human umbilical vein endothelial cells

In vitro interaction between surface‐treated Ti‐6Al‐4V titanium alloy and human peripheral blood mononuclear cells

Effect of micro-characterization on thrombus formation ability of TiO2 film

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