Bedroom exposure to airborne allergens in the Chicago area using a patient-operated sampling device

Gordon, Julian; Detjen, Paul; Nimmagadda, Sai; Rogers, Laura; Patel, Sanjay R.; Thompson, James L.; Reboulet, Rachel; Gandhi, Prasanthi

doi:10.1016/j.anai.2018.05.024

Cited by 3 publications

(18 citation statements)

References 15 publications

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“…Both allergens become aerosolized easily and remain airborne for long periods of time due to the aerodynamic characteristics of cat and dog allergen-carrying particles [34, 35]. Highest reservoir allergen concentrations are found in places where the pet(s) mostly reside (e.g., pets’ dens and living room upholstered furniture) [36, 37], but pet allergens spread throughout the home, including bedrooms, even if the pet’s access has been restricted [38]. Allergen levels have been shown to vary notably by race/ethnicity, socioeconomic status, geographic location, and housing characteristics [10•, 36, 39].…”

Section: Bedroom Allergen Exposuresmentioning

confidence: 99%

“…Allergen levels have been shown to vary notably by race/ethnicity, socioeconomic status, geographic location, and housing characteristics [10•, 36, 39]. While the presence of the pet(s) is the strongest predictor of elevated pet allergen levels, [10•, 36] allergen levels are also influenced by the number of pets and pet keeping habits [37, 38, 40]. However, exposure to cat and dog allergens is not limited to direct contact with pets [41, 42].…”

Section: Bedroom Allergen Exposuresmentioning

confidence: 99%

“…Household allergens are often studied individually, but residential exposure to multiple allergens is common [9, 10•, 38]. In many homes several allergens can be found at elevated levels, while the levels may vary by room and location [9, 10•].…”

Section: Bedroom Allergen Exposuresmentioning

confidence: 99%

“…New data, however, are emerging on additional allergens, including pollen and food, which have been found in bedrooms and other living spaces [38, 178, 179]. Although little data exist on less commonly owned pets such as rodents, recently published articles have discussed their role in allergic sensitization and disease [24, 61, 62, 180].…”

Section: Bedroom Allergen Exposuresmentioning

confidence: 99%

“…Although measuring personal exposure to airborne allergens in a longitudinal fashion is challenging for many technical and logistical reasons [201, 202•], progress has been reported, and recent studies have introduced new sampling equipment and approaches. [38, 179, 202•, 203–206]…”

Section: Bedroom Allergen Exposuresmentioning

confidence: 99%

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Bedroom Allergen Exposure Beyond House Dust Mites

Salo

Cohn²,

Zeldin

2018

Curr Allergy Asthma Rep

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Purpose of the review: The review provides insight into recent findings on bedroom allergen exposures, primarily focusing on pet, pest and fungal exposures. Recent findings: Large-scale studies and improved exposure assessment technologies, including measurement of airborne allergens and of multiple allergens simultaneously, has extended our understanding of indoor allergen exposures and their impact on allergic disease. Practical, streamlined methods for exposure reduction have shown promise in some settings, and potential protective effects of early-life exposures have been further elucidated through the investigation of specific bacterial taxa. Advances in molecular allergology have yielded novel data on sensitization profiles and cross-reactivity. Summary: The role of indoor allergen exposures in allergic disease is complex and remains incompletely understood. Advancing our knowledge of various co-exposures, including the environmental and host microbiome, that interact with allergens in early life will be crucial for the development of efficacious interventions to reduce the substantial economic and social burden of allergic diseases including asthma.

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Section: Bedroom Allergen Exposuresmentioning

confidence: 99%

Section: Bedroom Allergen Exposuresmentioning

confidence: 99%

Section: Bedroom Allergen Exposuresmentioning

confidence: 99%

Section: Bedroom Allergen Exposuresmentioning

confidence: 99%

Section: Bedroom Allergen Exposuresmentioning

confidence: 99%

See 3 more Smart Citations

Bedroom Allergen Exposure Beyond House Dust Mites

Salo

Cohn²,

Zeldin

2018

Curr Allergy Asthma Rep

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Concurrent measurement of microbiome and allergens in the air of bedrooms of allergy disease patients in the Chicago area

et al. 2019

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The particulate and biological components of indoor air have a substantial impact on human health, especially immune respiratory conditions such as asthma. To better explore the relationship between allergens, the microbial community, and the indoor living environment, we sampled the bedrooms of 65 homes in the Chicago area using 23the patient-friendly Inspirotec electrokinetic air sampling device, which collects airborne particles for characterization of both allergens and microbial DNA. The sampling device captured sufficient microbial material to enable 16S rRNA amplicon sequencing data to be generated for every sample in the study. Neither the presence of HEPA filters nor the height at which the air sampling device was placed had any influence on the microbial community profile. A core microbiota of 31 OTUs was present in more than three quarters of the samples, comprising around 45% of the relative sequence counts in each bedroom. The most abundant single organisms were Staphylococcus , with other core taxa both human and outdoor-associated. Bacterial alpha diversity was significantly increased in bedrooms that reported having open windows, those with flowering plants in the vicinity, and those in homes occupied by dogs. Porphyromonas , Moraxella , Sutterella , and Clostridium , along with family Neisseraceae , were significantly enriched in homes with dogs; interestingly, cats did not show a significant impact on microbial diversity or relative abundance. While dog allergen load was significantly correlated with bacterial alpha diversity, the taxa that significantly correlated with allergen burden did not exclusively overlap with those enriched in homes with dogs. Alternaria allergen load was positively correlated with bacterial alpha diversity, while Aspergillus allergen load was negatively correlated. The Alternaria allergen load was also significantly correlated with open windows. Microbial communities were significantly differentiated between rural, suburban, and urban homes and houses that were physically closer to each other maintained significantly more similar microbiota. We have demonstrated that it is possible to determine significant associations between allergen burden and the microbiota in air from the same sample and that these associations relate to the characteristics of the home and neighborhoods. Electronic supplementary material The online version of this article (10.1186/s40168-019-0695-5) contains supplementary material, which is available to authorized users.

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Airborne Rodent Allergen Levels in Dutch Households: A Pilot Study

Burt

Dolcet

Wouters

2019

IJERPH

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Little research has been conducted in Europe regarding indoor exposure to airborne rodent allergens. The aims of this study were to gain insight into the prevalence of rodent allergens in airborne dust in Dutch households, to assess whether there is a relationship between rodent sightings and detectable allergens, and to identify risk factors associated with the presence of rodent allergens. Airborne dust was collected from the living rooms of 80 households distributed around central Netherlands by passive sampling using electrostatic dust collectors (EDCs). Samples were analysed for mouse (Mus m 1) and rat (Rat n 1) allergens. Participants completed a questionnaire on household and building characteristics, household pets, cleaning habits and ventilation. Mouse allergen was more prevalent than rat allergen and mouse sightings within the past year more than doubled the odds of detectable mouse allergen. Proximity to green areas, ventilation through an open window and insulation under the living room floor were determinants for detectable mouse allergen. Conversely, proximity to surface water was protective. No significant association was found between asthma and detectable mouse allergen. The passive EDC sampling method was used successfully to detect mouse and rat allergens in homes. The presence of mouse allergen was associated with previous mouse sightings. Risk factors and protective factors associated with the presence and levels of mouse allergen were identified.

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Bedroom exposure to airborne allergens in the Chicago area using a patient-operated sampling device

Cited by 3 publications

References 15 publications

Bedroom Allergen Exposure Beyond House Dust Mites

Bedroom Allergen Exposure Beyond House Dust Mites

Concurrent measurement of microbiome and allergens in the air of bedrooms of allergy disease patients in the Chicago area

Airborne Rodent Allergen Levels in Dutch Households: A Pilot Study

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