Basic Reproduction Number and Transmission Dynamics of Common Serogroups of Enterohemorrhagic Escherichia coli

Chen, Shi; Sanderson, Michael W.; Lee, Chihoon; Cernicchiaro, Natalia; Renter, David G.; Lanzas, Cristina

doi:10.1128/aem.00815-16

Cited by 7 publications

(3 citation statements)

References 42 publications

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“…A single kitten with diarrhea in this study was colonized by a serotype O111 aEPEC isolate. Strains of serotype O111 have been identified to be aEPEC, tEPEC, enteroaggregative E. coli, and non-O157 EHEC strains (46)(47)(48)(49)(50). This is of interest due to the ability of these aEPEC strains to arise from the loss of stx genes by EHEC or to acquire stx genes by infection with phages whose genomes encode stx (51-54).…”

Section: Discussionmentioning

confidence: 99%

Association of Atypical Enteropathogenic Escherichia coli with Diarrhea and Related Mortality in Kittens

et al. 2017

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Diarrhea is responsible for the death of approximately 900,000 children per year worldwide. In children, typical enteropathogenic (EPEC) is a common cause of diarrhea and is associated with a higher hazard of death. Typical EPEC infection is rare in animals and poorly reproduced in experimental animal models. In contrast, atypical EPEC (aEPEC) infection is common in both children and animals, but its role in diarrhea is uncertain. Mortality in kittens is often attributed to diarrhea, and we previously identified enteroadherent EPEC in the intestines of deceased kittens. The purpose of this study was to determine the prevalence and type of EPEC in kittens and whether infection was associated with diarrhea, diarrhea-related mortality, gastrointestinal pathology, or other risk factors. Kittens with and without diarrhea were obtained from two shelter facilities and determined to shed atypical EPEC at a culture-based prevalence of 18%. In contrast, quantitative PCR detected the presence of the gene for intimin () in feces from 42% of kittens. aEPEC was isolated from kittens with and without diarrhea. However, kittens with diarrhea harbored significantly larger quantities of aEPEC than kittens without diarrhea. Kittens with aEPEC had a significantly greater severity of small intestinal and colonic lesions and were significantly more likely to have required subcutaneous fluid administration. These findings identify aEPEC to be prevalent in kittens and a significant primary or contributing cause of intestinal inflammation, diarrhea, dehydration, and associated mortality in kittens.

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Section: Discussionmentioning

confidence: 99%

Association of Atypical Enteropathogenic Escherichia coli with Diarrhea and Related Mortality in Kittens

et al. 2017

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“…No Entanto, é importante ressaltar que diferenças fenotípicas e genotípicas entre patógenos da mesma espécie, como cepas de MRSA tipos ST22, ST36 e ST239-TW podem apresentar diferentes perfis de virulência/transmissibilidade e persistência nos hospedeiros, ocorrendo na maioria das vezes a identificação de tais patógenos somente após a manifestação de um número significativo de casos de doença, que em meio a ambientes como hospitais, cuja rotatividade de hospedeiros se altera constantemente, diferentes perfis de colonização e transmissão podem ser observados (COOPER et al, 2012;CHEN et al, 2016).…”

Section: Condicionantes E Determinantes Da Transmissão De Bactérias Resistentes Aos Antibióticos Em Ambientes Hospitalaresunclassified

Modelagem matemática de infecções bacterianas causadas por patógenos resistentes: Uma revisão sistemática da dinâmica de transmissão e seus determinantes em populações humanas

Costa¹,

Neto²,

Souza³

2020

Revista Arquivos Científicos (IMMES)

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Resistência bacteriana Epidemiologia Modelagem matemática Saúde pública Doenças infecciosasA resistência bacteriana aos antibióticos é uma ameaça à saúde pública responsável pela perda da eficácia dos antibióticos, que afeta toda a população mundial, tendendo a se intensificar nas próximas décadas em função da pouca frequência com que novos antibióticos são lançados no mercado, devido ao fato de serem menos lucrativos do que medicamentos para o tratamento de doenças crônicas. Neste contexto, este trabalho teve como objetivo procurar identificar fatores que condicionam a dinâmica de transmissão de infecções bacterianas causadas por patógenos resistentes por meio de uma revisão sistemática da literatura acerca da dinâmica de transmissão em sistemas matemáticos deterministas, com o intuito de levantar informações relevantes para a promoção de estratégias de prevenção ao nível primário contra a resistência bacteriana. Sendo os fatores condicionantes detectados e reportados neste trabalho: Programas de imunização sem quantitativo de público-alvo apropriado, lavagem das mãos inapropriada por parte dos profissionais de saúde, longos intervalos na periodicidade da sanitização de ambientes hospitalares, extensivo uso de antibióticos ao nível populacional, e o fluxo de pessoas de localidades com grande densidade populacional e elevada prevalência de resistência bacteriana para locais com menor densidade populacional e baixa prevalência de resistência bacteriana

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“…Where values of R0> 1 indicate a considerable predictive risk of epidemic events, while values of R0 <1 indicate a low risk for the occurrence of epidemic events, and informing the ideal amount of individuals in the population to be approached by control strategies in order to be effective by reaching the value of 1-(1 / R0) (KEELING; DA-NON, 2009;COOPER et al, 2012, CHEN et al, 2016DRIESSCHE, 2017).…”

Section: A Mathematical Approach To the Dynamics Of Infectious Diseasesmentioning

confidence: 99%

Conditioners of the infectious diseases dynamics

Costa

Neto

Silva-Júnior

2019

Est. Cient. (UNIFAP)

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The natural history of diseases is a concept in epidemiology that describes at the individual level the interaction of an individual with a disease stimulus, its clinical horizons, and transmission routes, which enable the identification of critical points for the prevention and control of infectious diseases. However, although this concept implies a dynamic process of exposure, contraction of disease, and cure or death, it does not provide an understanding of the dynamics of transmission of infectious agents at the population level in different scenarios, where anthropological, biological, clinical and social factors can act as conditioners for infectious diseases, that can manifest and transform in a variety of ways in different human populations. In this context, the objective of this work was to review the literature according to the Cooper (1988) methodology, to generate perspectives on the dynamics of infectious diseases, their conditioners and their interrelationship. It is demonstrated that environmental changes, pathogens evolution and host co-evolution, as well as behavioral and social set, influence significantly the epidemic events, and mathematical modeling represents an important tool to analyze this influence.

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Basic Reproduction Number and Transmission Dynamics of Common Serogroups of Enterohemorrhagic Escherichia coli

Cited by 7 publications

References 42 publications

Association of Atypical Enteropathogenic Escherichia coli with Diarrhea and Related Mortality in Kittens

Association of Atypical Enteropathogenic Escherichia coli with Diarrhea and Related Mortality in Kittens

Modelagem matemática de infecções bacterianas causadas por patógenos resistentes: Uma revisão sistemática da dinâmica de transmissão e seus determinantes em populações humanas

Conditioners of the infectious diseases dynamics

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