1998
DOI: 10.1097/00075197-199805000-00010
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Basic principles for compounding all-in-one parenteral nutrition admixtures

Abstract: Parenteral nutrition admixtures are complex pharmaceutical entities. The more closely they are examined, the more physico-chemical interactions emerge that could potentially affect stability. The move towards large scale hospital or commercial preparation, with a requirement for extended shelf life, and the increasing use of admixtures as vehicles for drugs and pharmaconutrients have created new formulation challenges for pharmaceutical scientists.

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Cited by 26 publications
(24 citation statements)
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“…The risk of catheter-related bloodstream infection remains one of the most serious complications associated with PN [101]. Temporary or short-term central venous catheters account for about 90% of nosocomial blood stream infections, and only 10% of infections are from long-term devices such as tunneled catheters or implanted reservoirs [102].…”
Section: Infectiousmentioning
confidence: 99%
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“…The risk of catheter-related bloodstream infection remains one of the most serious complications associated with PN [101]. Temporary or short-term central venous catheters account for about 90% of nosocomial blood stream infections, and only 10% of infections are from long-term devices such as tunneled catheters or implanted reservoirs [102].…”
Section: Infectiousmentioning
confidence: 99%
“…The patients can also develop local site infections, port pocket infections, or catheter tunnel infections without developing a full blood stream infection. Signs and symptoms associated with catheter-related sepsis include fever, rigors, malaise, defervescence of fever after catheter removal, and positive blood cultures [102]. Treatment options include catheter removal, antibiotic lock, or delivery of systematic antibiotics via the catheter [93].…”
Section: Infectiousmentioning
confidence: 99%
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