Basic and Translational Models of Cooperative Oncogenesis

Richardson, Helena E.; Cordero, Julia B.; Grifoni, Daniela

doi:10.3390/ijms21165919

Cited by 4 publications

(4 citation statements)

References 41 publications

(55 reference statements)

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“…Based on these studies, the Agency for Research on Cancer (IARC) has classified radiofrequency electromagnetic fields as possibly carcinogenic to humans (Group 2B). In recent years, many transgenic models of cancer have been developed in Drosophila [ 106 , 107 , 108 ]. In flies, there are many genes related to cancer and for which human functional homologues have been identified, such as oncogenes, tumor suppressors and genes whose mutation causes neoplastic growth [ 106 , 108 ].…”

Section: Resultsmentioning

confidence: 99%

“…In recent years, many transgenic models of cancer have been developed in Drosophila [ 106 , 107 , 108 ]. In flies, there are many genes related to cancer and for which human functional homologues have been identified, such as oncogenes, tumor suppressors and genes whose mutation causes neoplastic growth [ 106 , 108 ]. It has also been shown that many signaling pathways are conserved from flies to humans, giving Drosophila functional relevance in the study of human cancer biology [ 106 , 109 , 110 ].…”

Section: Resultsmentioning

confidence: 99%

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WiFi Related Radiofrequency Electromagnetic Fields Promote Transposable Element Dysregulation and Genomic Instability in Drosophila melanogaster

Cappucci

Casale

Proietti

et al. 2022

Cells

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Exposure to artificial radio frequency electromagnetic fields (RF-EMFs) has greatly increased in recent years, thus promoting a growing scientific and social interest in deepening the biological impact of EMFs on living organisms. The current legislation governing the exposure to RF-EMFs is based exclusively on their thermal effects, without considering the possible non-thermal adverse health effects from long term exposure to EMFs. In this study we investigated the biological non-thermal effects of low-level indoor exposure to RF-EMFs produced by WiFi wireless technologies, using Drosophila melanogaster as the model system. Flies were exposed to 2.4 GHz radiofrequency in a Transverse Electromagnetic (TEM) cell device to ensure homogenous controlled fields. Signals were continuously monitored during the experiments and regulated at non thermal levels. The results of this study demonstrate that WiFi electromagnetic radiation causes extensive heterochromatin decondensation and thus a general loss of transposable elements epigenetic silencing in both germinal and neural tissues. Moreover, our findings provide evidence that WiFi related radiofrequency electromagnetic fields can induce reactive oxygen species (ROS) accumulation, genomic instability, and behavioural abnormalities. Finally, we demonstrate that WiFi radiation can synergize with RasV12 to drive tumor progression and invasion. All together, these data indicate that radiofrequency radiation emitted from WiFi devices could exert genotoxic effects in Drosophila and set the stage to further explore the biological effects of WiFi electromagnetic radiation on living organisms.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

WiFi Related Radiofrequency Electromagnetic Fields Promote Transposable Element Dysregulation and Genomic Instability in Drosophila melanogaster

Cappucci

Casale

Proietti

et al. 2022

Cells

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“…Over the past decades, significant progress has been achieved in the study of tumor biology, the study of the mechanisms of control of tumor metastasis, apoptosis, invasion, angiogenesis, and proliferation of tumor cells. These data were obtained by studying the cellular composition and microenvironment of tumors, various intracellular signaling pathways, and molecular processes of oncogenesis (Richardson et al, 2020). MicroRNAs (miRNAs) are 18-22 nucleotide endogenous non-coding RNAs that regulate gene expression at the post-transcriptional level by interacting with 3 -untranslated regions (3 -UTR) of mRNAtargets (Lu and Rothenberg, 2018; Figure 1).…”

Section: Introductionmentioning

confidence: 99%

The Role of MicroRNAs in Therapeutic Resistance of Malignant Primary Brain Tumors

Gareev

Beylerli

Liang

et al. 2021

Front. Cell Dev. Biol.

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Brain tumors in children and adults are challenging tumors to treat. Malignant primary brain tumors (MPBTs) such as glioblastoma have very poor outcomes, emphasizing the need to better understand their pathogenesis. Developing novel strategies to slow down or even stop the growth of brain tumors remains one of the major clinical challenges. Modern treatment strategies for MPBTs are based on open surgery, chemotherapy, and radiation therapy. However, none of these treatments, alone or in combination, are considered effective in controlling tumor progression. MicroRNAs (miRNAs) are 18–22 nucleotide long endogenous non-coding RNAs that regulate gene expression at the post-transcriptional level by interacting with 3′-untranslated regions (3′-UTR) of mRNA-targets. It has been proven that miRNAs play a significant role in various biological processes, including the cell cycle, apoptosis, proliferation, differentiation, etc. Over the last decade, there has been an emergence of a large number of studies devoted to the role of miRNAs in the oncogenesis of brain tumors and the development of resistance to radio- and chemotherapy. Wherein, among the variety of molecules secreted by tumor cells into the external environment, extracellular vesicles (EVs) (exosomes and microvesicles) play a special role. Various elements were found in the EVs, including miRNAs, which can be transported as part of these EVs both between neighboring cells and between remotely located cells of different tissues using biological fluids. Some of these miRNAs in EVs can contribute to the development of resistance to radio- and chemotherapy in MPBTs, including multidrug resistance (MDR). This comprehensive review examines the role of miRNAs in the resistance of MPBTs (e.g., high-grade meningiomas, medulloblastoma (MB), pituitary adenomas (PAs) with aggressive behavior, and glioblastoma) to chemoradiotherapy and pharmacological treatment. It is believed that miRNAs are future therapeutic targets in MPBTs and such the role of miRNAs needs to be critically evaluated to focus on solving the problems of resistance to therapy this kind of human tumors.

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“…A large-scale genetic screen is an effective unbiased method to systematically dissect the genetic bases in RAS -related tumors. Over the last few decades, Drosophila has been proven to be an excellent model organism for cancer research [ 5 , 6 , 7 , 8 ] and a variety of tumor models have been established in Drosophila [ 9 , 10 , 11 , 12 ]. Importantly, the genetic screens in Drosophila have identified that the disruption of cell polarity genes ( scrib , dlg , lgl ) collaborate with oncogenic Ras ( Ras V12 ) or Notch to promote tumor overgrowth and invasion [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Misshapen Disruption Cooperates with RasV12 to Drive Tumorigenesis

Kong

et al. 2021

Cells

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Although RAS family genes play essential roles in tumorigenesis, effective treatments targeting RAS-related tumors are lacking, partly because of an incomplete understanding of the complex signaling crosstalk within RAS-related tumors. Here, we performed a large-scale genetic screen in Drosophila eye imaginal discs and identified Misshapen (Msn) as a tumor suppressor that synergizes with oncogenic Ras (RasV12) to induce c-Jun N-terminal kinase (JNK) activation and Hippo inactivation, then subsequently leads to tumor overgrowth and invasion. Moreover, ectopic Msn expression activates Hippo signaling pathway and suppresses Hippo signaling disruption-induced overgrowth. Importantly, we further found that Msn acts downstream of protocadherin Fat (Ft) to regulate Hippo signaling. Finally, we identified msn as a Yki/Sd target gene that regulates Hippo pathway in a negative feedback manner. Together, our findings identified Msn as a tumor suppressor and provide a novel insight into RAS-related tumorigenesis that may be relevant to human cancer biology.

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Basic and Translational Models of Cooperative Oncogenesis

Abstract: n/a

Cited by 4 publications

References 41 publications

WiFi Related Radiofrequency Electromagnetic Fields Promote Transposable Element Dysregulation and Genomic Instability in Drosophila melanogaster

WiFi Related Radiofrequency Electromagnetic Fields Promote Transposable Element Dysregulation and Genomic Instability in Drosophila melanogaster

The Role of MicroRNAs in Therapeutic Resistance of Malignant Primary Brain Tumors

Misshapen Disruption Cooperates with RasV12 to Drive Tumorigenesis

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