Basal Metabolism in Chronic Myelogenous Leukemia

Riddle, Matthew C.; Sturgis, Cyrus C.

doi:10.1001/archinte.1927.00130020094007

Arch Intern Med

1927

DOI: 10.1001/archinte.1927.00130020094007

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Basal Metabolism in Chronic Myelogenous Leukemia

Matthew C. Riddle¹,

Cyrus C. Sturgis²

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1927

1988

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Cited by 19 publications

(2 citation statements)

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“…This was to be expected as the very high oxygen requirement of the leukiemic cells is regarded as being the cause of the increased metabolism, and the number of primitive cells and the level of the B.M.R. show a direct relationship to each other in most cases (Riddle and Sturgis, 1927). There are, however, instances where this relationship does not appear to exist and a high B.M.R.…”

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confidence: 94%

Chronic Myeloid Leukæmia: Goitre and Raised B.M.R

Js¹

1946

Proceedings of the Royal Society of Medicine

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History (9.10.42).-Torpedoed off W. Coast of Africa, subsequently spending two hours in water and ten davs in life,boat. Apparently satisfactory recovery. One month later attack of conjunctivitis, duration one month.About Februarv 1943 onset of general fatigue and lassitude, folloved a few weeks later by aching pains in limbs and back. Symptoms were intermittent, and he remained at work. Started to lose weight about December 1944.March 1945: Sudden attack of stiffness involving whole body except head and neck. Admitted to hospital and treated as fibrositis without improvement.19.10.45: Admitted Archway L.C.C. Hospital. Diagnosis: "Myositis of unknown origin." Eosinophilia suggested trichinosis. X-rays of limbs showed no opacities. No muscle biopsv. Treated with phvsiotherapv. Condition slowly deteriorated. Soon after admission complained of dimness of vision, followed a few weeks later bv thirst and polyuria. Discharged 22.12.45 and admitted to Seaman's Hospital 27.12.45.Positive findings.-Apathy and profound lassitude. General wasting. Dry, sore tongue. B.P. 190/130. Bilateral diminution of visual acuitv, retinal hemorrhages and exudate. Muscular wasting, poor tone; movement and co-ordination normal. Sensation: Small area of diminished light touch on dorsum of both feet. Absent tendon reflexes. Abdominal reflexes present. Plantars flexor. Heart not enlarged.Investigations 31.12.45.-X-rav of chest, right leg, skull, nothing abnormal found.

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Chronic Myeloid Leukæmia: Goitre and Raised B.M.R

Js¹

1946

Proceedings of the Royal Society of Medicine

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“…Patients with leucemia frequently have an elevated basal metabolic rate, particularly when the blood contains many immature cells (Riddle and Sturgis (2)). The possibility of a causal relationship between the rate of oxygen absorption by the patient and the degree of maturation of the blood cells presents a problem toward the solution of which this study of cell respiration in the microspirometer offers some data.…”

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confidence: 99%

Cell Respiration Studies

Daland

Isaacs

1927

Journal of Experimental Medicine

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The observation by Warburg (1) that the amount of oxygen used by a slice of Flexner-Jobling rat carcinoma was less than that absorbed by such normal tissues as liver or kidney, has opened the way for the further study of the metabolism of tumor and other rapidly growing cells. The immature white blood ceils of myelogenous leucemia resemble somewhat those of the malignant neoplasms in their growth rate and behavior, and response to exposures to Roentgen rays. They serve as excellent material for the study of oxygen consumption because of their availability and the ease with which they can be manipulated in vitro.Patients with leucemia frequently have an elevated basal metabolic rate, particularly when the blood contains many immature cells (Riddle and Sturgis (2)). The possibility of a causal relationship between the rate of oxygen absorption by the patient and the degree of maturation of the blood cells presents a problem toward the solution of which this study of cell respiration in the microspirometer offers some data.The studies reported here include observations on the blood of normal individuals, a patient with a leucocytosis from sepsis, and patients with chronic myelogenous leucemia in various stages of the disease.

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Relationship Between Oxygen Consumption and Nitrogen Metabolism

Baldridge¹,

Barer²

1933

Arch Intern Med (Chic)

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Basal Metabolism in Chronic Myelogenous Leukemia

Cited by 19 publications

References 8 publications

Chronic Myeloid Leukæmia: Goitre and Raised B.M.R

Chronic Myeloid Leukæmia: Goitre and Raised B.M.R

Cell Respiration Studies

Relationship Between Oxygen Consumption and Nitrogen Metabolism

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