Chronic Myeloid Leukæmia: Goitre and Raised B.M.R

Abstract

History (9.10.42).-Torpedoed off W. Coast of Africa, subsequently spending two hours in water and ten davs in life,boat. Apparently satisfactory recovery. One month later attack of conjunctivitis, duration one month.About Februarv 1943 onset of general fatigue and lassitude, folloved a few weeks later by aching pains in limbs and back. Symptoms were intermittent, and he remained at work. Started to lose weight about December 1944.March 1945: Sudden attack of stiffness involving whole body except head and neck. Admitted to hospital and treated as fibrositis without improvement.19.10.45: Admitted Archway L.C.C. Hospital. Diagnosis: "Myositis of unknown origin." Eosinophilia suggested trichinosis. X-rays of limbs showed no opacities. No muscle biopsv. Treated with phvsiotherapv. Condition slowly deteriorated. Soon after admission complained of dimness of vision, followed a few weeks later bv thirst and polyuria. Discharged 22.12.45 and admitted to Seaman's Hospital 27.12.45.Positive findings.-Apathy and profound lassitude. General wasting. Dry, sore tongue. B.P. 190/130. Bilateral diminution of visual acuitv, retinal hemorrhages and exudate. Muscular wasting, poor tone; movement and co-ordination normal. Sensation: Small area of diminished light touch on dorsum of both feet. Absent tendon reflexes. Abdominal reflexes present. Plantars flexor. Heart not enlarged.Investigations 31.12.45.-X-rav of chest, right leg, skull, nothing abnormal found.