Basal and Spasmolytic Effects of a Hydroethanolic Leaf Extract of <i>Melissa officinalis</i> L. on Intestinal Motility: An <i>Ex Vivo</i> Study

Aubert, P.; Guinobert, Isabelle; Blondeau, Claude; Bardot, Vale ́rie; Ripoche, Isabelle; Cartigny, Pierre; Neunlist, Michel

doi:10.1089/jmf.2018.0154

Cited by 21 publications

(14 citation statements)

References 25 publications

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“…Luteolin significantly decreases the size of gastric lesions induced by gastric mucosal exposure to indomethacin [ 48 ]. Acacetin and diosmetin inhibited H. pylori growth, which causes human gastrointestinal diseases [ 49 ]. Kangwan et al reported that rosmarinic acid acts as a protective agent against gastric ulcers caused by indomethacin [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Effects of Agastache rugosa against Gastritis Using a Network Pharmacology Approach

et al. 2020

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Agastache rugosa is used as a Korean traditional medicine to treat gastric diseases. However, the active ingredients and pharmacological targets of A. rugosa are unknown. In this study, we aimed to reveal the pharmacological effects of A. rugosa on gastritis by combining a mice model and a network pharmacology method. The macrophage and gastritis-induced models were used to evaluate the pharmacological effects of A. rugosa. The results show that A. rugosa relieved mucosal damage induced by HCl/EtOH in vivo. Network analysis identified 99 components in A. rugosa; six components were selected through systematic screening, and five components were linked to 45 gastritis-related genes. The main components were acacetin and luteolin, and the identified core genes were AKT serine/threonine kinase 1 (AKT1), nuclear factor kappa B inhibitor alpha (NFKBIA), and mitogen-activated protein kinase-3 (MAPK3) etc. in this network. The network of components, target genes, protein–protein interactions, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway was closely connected with chemokines and with phosphoinositide 3-kinase-Akt (PI3K/AKT), tumor-necrosis-factor alpha (TNFα), mitogen-activated protein kinase, nuclear factor kappa B, and Toll-like receptor (TLR) pathways. In conclusion, A. rugosa exerts gastro-protective effects through a multi-compound and multi-pathway regulatory network and holds potential for treating inflammatory gastric diseases.

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Section: Discussionmentioning

confidence: 99%

Pharmacological Effects of Agastache rugosa against Gastritis Using a Network Pharmacology Approach

et al. 2020

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“…The leaves were extracted in 70% ethanol, which resulted in the following compounds quantified using liquid chromatographymass spectrometry (LC-MS): gallic acid, chlorogenic acid, caffeic acid, rosmarinic acid, ellagic acid, rutin, isoquercitrin, quercetin, and kaempferol. Aubert et al [84] identified the following compounds from hydroethanolic leaf extract of M. officinalis using LC-MS: tartaric acid, quinic acid, malic acid, citric acid, succinic acid, danshensu, caftaric acid, salicylic acid, caffeic acid, lithospermic acid A, chicoric acid, luteolin 3 ′ -O-β-D-glucuronide, rosmarinic acid, 3 ′ -O-(8 ′ -Z-caffeoyl)rosmarinic acid, and ethyl caffeate.…”

Section: Chemical Compositionmentioning

confidence: 99%

[Retracted] Phytochemical Constituents, Biological Activities, and Health‐Promoting Effects of the Melissa officinalis

Sharifi‐Rad

Quispe

Herrera‐Bravo

et al. 2021

Oxidative Medicine and Cellular Longevity

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Medicinal plants are being used worldwide for centuries for their beneficial properties. Some of the most popular medicinal plants belong to the Melissa genus, and different health beneficial effects have already been identified for this genus. Among these species, in particular, the Melissa officinalis L. has been reported as having many biological activities, such as antioxidant, antimicrobial, antitumour, antiviral, antiallergic, anti-inflammatory, and also flatulence inhibiting effects. The beneficial properties of the Melissa officinalis, also known as “lemon balm herb”, can be related to the bioactive compounds such as terpenoids, alcohols, rosmarinic acid, and phenolic antioxidants which are present in the plant. In this updated review, the botanical, geographical, nutritional, phytochemical, and traditional medical aspects of M. officinalis have been considered as well as in vitro and in vivo and clinically proven therapeutic properties have been reviewed with a special focus on health-promoting effects and possible perspective nutraceutical applications. To evidence the relevance of this plant in the research and completely assess the context, a literature quantitative research analysis has been performed indicating the great interest towards this plant for its beneficial properties.

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“…As previously described (27,29), at the end of the fecal pellet collection for the control mice and after the WAS treatment the fourth day, animals were killed by cervical dislocation. Tissues were immediately transferred in cold HBSS (Eurobio, Courtaboeuf, France) after surgical resection and brought to the laboratory.…”

Section: Ex Vivo Measurement Of Colonic Motilitymentioning

confidence: 99%

Psychological Stress Induces an Increase in Cholinergic Enteric Neuromuscular Pathways Mediated by Glucocorticoid Receptors

Blin

Gautier

Arnaúd

et al. 2022

Preprint

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Repeated acute stress (RASt) is known to be associated with gastrointestinal dysfunctions. However, mechanisms underlying these effects are not fully understood. While glucocorticoids are clearly identified as hormones of stress, their implication, and those of their specific glucocorticoid receptors (GR), in RASt induced gut dysfunctions remain unclear. The aim of our study was to evaluate the involvement of GR on RASt induced changes in gut motility, particularly through the enteric nervous system (ENS). Using a murine water avoidance stress model, we characterized the impact of RASt upon ENS phenotype and colonic motility. Next, the expression of GR onto the ENS and their functional impact upon RASt induced changes in ENS phenotype and motor response were evaluated. We showed that the GR was expressed in myenteric neurons in the distal colon under basal condition, and that RASt enhanced its nuclear translocation. RASt increased the proportion of ChAT-IR neurons, acetylcholine tissue concentration, and enhanced cholinergic neuromuscular transmission as compared to control. Finally, we showed that GR specific antagonist (CORT108297) prevented the increase of acetylcholine and in vivo colonic motility. Altogether our study suggests that RASt-induced functional changes in motility are, at least partly, due to GR dependent enhanced cholinergic ENS phenotype.

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Basal and Spasmolytic Effects of a Hydroethanolic Leaf Extract of Melissa officinalis L. on Intestinal Motility: An Ex Vivo Study

Cited by 21 publications

References 25 publications

Pharmacological Effects of Agastache rugosa against Gastritis Using a Network Pharmacology Approach

Pharmacological Effects of Agastache rugosa against Gastritis Using a Network Pharmacology Approach

[Retracted] Phytochemical Constituents, Biological Activities, and Health‐Promoting Effects of the Melissa officinalis

Psychological Stress Induces an Increase in Cholinergic Enteric Neuromuscular Pathways Mediated by Glucocorticoid Receptors

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