Barrier recovery rate varies time-dependently in human skin

Denda, Mitsuhiro; Tsuchiya, Toru

doi:10.1046/j.1365-2133.2000.03466.x

Cited by 72 publications

(52 citation statements)

References 18 publications

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“…The identification of surface cortisol in this study is significant and may be a result of the response to various environmental stressors, particularly in the premature infant. Stress due to environmental overcrowding was associated with a delay in skin barrier recovery in mice, an effect attributed to increased production of glucocorticoids (46). Psychological stress decreased epidermal cell proliferation, adversely effected differentiation and decreased the size and density of corneodesmosomes, all of which negatively impact barrier function (47).…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of Epidermal Innate Immunity in Premature and Full-Term Infants

et al. 2010

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ABSTRACT:Epidermal innate immunity is a complex process involving a balance of pro-and anti-inflammatory cytokines, structural proteins, and specific antigen presenting cells occurring against a background of neuroendocrine modulators such as cortisol. In this study, a multiplex array system was used to simultaneously determine multiple molecular factors critical for development of epidermal innate immune function from the skin surface of premature and term infants, healthy adults, and vernix caseosa. Samples were analyzed for Keratin 1,10,11, Keratin 6, involucrin, albumin, fibronectin and cortisol, and cytokines IL-1, TNF␣, IL-6, IL-8, MCP1, IP10, IFN␥, and IL-1 receptor antagonist. Keratin 1,10,11 was decreased and involucrin was increased in infants versus adults. All infants had elevated IL1␣ and reduced TNF␣ versus adults. IL-6, IL-8, and MCP1 were significantly increased in premature versus term infants and adults. Skin surface cortisol and albumin were significantly elevated in premature infants. The biomarker profile in premature infants was unique with differences in structural proteins, albumin, and cytokines IL-6, IL-1␤, IL-8, and MCP1. The higher infant IL1␣ may be associated with skin barrier maturation. The significant elevations in skin surface cortisol for preterm infants may reflect a neuroendocrine response to the stress of premature birth. (Pediatr Res 67: 382-386, 2010)

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Section: Discussionmentioning

confidence: 99%

Biomarkers of Epidermal Innate Immunity in Premature and Full-Term Infants

et al. 2010

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“…The barrier recovery rate varies time dependently in human skin [36] . After SC stripping, the TEWL increases but rapidly returns to normal within a couple of days [23,24,28] .…”

Section: Discussionmentioning

confidence: 99%

Repair Kinetics of the Stratum corneum under Repeated Insults

Uhoda

Franchimont

Debatisse³

et al. 2004

Exog Dermatol

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Background: The stratum corneum (SC) structure and functions are altered by surfactants. Enhancing the repair mechanisms is a goal for some skin care formulations. Aim: To design an experimental procedure allowing the discrimination of repair efficacy for topical products applied to threatened SC. Method: Controlled SC strippings followed by repeated forearm soak sessions in surfactant solutions were used to compromise the SC barrier function in 20 volunteers. Two test formulations were compared. They were applied twice daily for 2 weeks before initiating the SC damages, and for the next 2 weeks while sustaining the procedure of soak sessions. Daily assessments involved objective measurements of parameters including transepidermal water loss, the value of the passive sustainable SC hydration and the epidermal turnover rate using the dihydroxyacetone test. Result: The experimental procedure allowed to clearly distinguish the differences in the kinetics of SC repair between the topical formulations. In the present study design, the repair of the barrier function mirrored the SC renewal. Conclusion: The present experimental design slows down the repair rate of the SC barrier function. Thus, it increases the sensitivity of biometrological measurements assessing some of the major SC properties. It also better mimics the common in vivo situation experienced by subjects chronically exposed to irritant xenobiotics.

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“…Room temperature was 24 8 1 ° C and the relative humidity in the range of 50-60%. The laboratory procedures were always performed between 8: 00 and 10: 00 a.m. to avoid the possible effects of circadian rhythm [30] .…”

Section: Methodsmentioning

confidence: 99%

Dynamics of Skin Barrier Repair following Topical Applications of Miconazole Nitrate

Xhauflaire-Uhoda

Vroome²,

Cauwenbergh³

et al. 2006

Skin Pharmacol Physiol

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The skin barrier function (SBF) is an important aspect of skin biology, particularly in the elicitation of inflammation. The SBF recovery rate after tape stripping and surfactant challenge can be assessed by measuring the transepidermal water loss (TEWL). Previous clinical studies have shown some inflammatory effect after topical applications of miconazole. The aim of this study was to compare the effect of pastes (petrolatum and 15% zinc oxide) containing or not miconazole nitrate on controlled impaired SBF. Fifteen volunteers were enrolled. In each subject, successive cyanoacrylate skin surface strippings were harvested from 5 sites of the volar forearm until TEWL raised above 15 g/cm²/h on all test sites. In addition, one daily soak session with a 0.2% dishwashing liquid further damaged the SBF. Each of the test formulations was applied twice daily for 5 days at two dosages, namely 1 and 2 mg/cm², on randomized test sites. Another site remained untreated. TEWL was measured daily for 5 days. A fastened SBF repair was observed on all treated sites, particularly where the largest amount of the products had been applied. A faster SBF recovery rate was obtained at the site receiving the miconazole nitrate paste. We conclude that the occlusive effect of a paste helped mitigate SBF defect. The adjunction of miconazole nitrate improved the efficacy.

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Barrier recovery rate varies time-dependently in human skin

Cited by 72 publications

References 18 publications

Biomarkers of Epidermal Innate Immunity in Premature and Full-Term Infants

Biomarkers of Epidermal Innate Immunity in Premature and Full-Term Infants

Repair Kinetics of the Stratum corneum under Repeated Insults

Dynamics of Skin Barrier Repair following Topical Applications of Miconazole Nitrate

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