Baicalin regulates mRNA expression of VEGF‐c, Ang‐1/Tie2, TGF‐β and Smad2/3 to inhibit wound healing in streptozotocin‐induced diabetic foot ulcer rats

Mao, Xuefei; Li, Zhi; Bao-gang, LI; Wang, Haiping

doi:10.1002/jbt.22893

Cited by 13 publications

(10 citation statements)

References 19 publications

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“…During the inflammatory phase, fibroblasts migrate to the wound site, and various growth factors such as TGF-β1 and Ang-1 are released from keratinocytes [71]. Ang-1 and TGF-β are also needed, as they regulate the production of collagen and ensure the availability of hydroxyproline [78]. FLX is known to induce TGF-β1 synthesis and release in vitro in glial cells [79] as well as in humans [80], but no studies have been conducted in experimental models of wound healing yet.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Fluoxetine Ecofriendly Nanoemulsion Enhances Wound Healing in Diabetic Rats: In Vivo Efficacy Assessment

et al. 2022

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Impaired diabetic wound healing is a major concern for health care professionals worldwide, imposing an intense financial burden and reducing the quality of life of patients. A dysregulation of this process can be responsible for the development of intractable ulcers and the formation of excessive scars. Therefore, the identification of novel pharmacological strategies able to promote wound healing and restore the mechanical integrity of injured tissue becomes essential. In the present study, fluoxetine ecofriendly nanoemulsion (FLX-EFNE) was prepared and its potential efficacy in enhancing wound healing was tested in diabetic rats. The Box–Behnken response surface design was used to select the optimized formulation that was prepared by the high-shear homogenization-based technique. A Zetasizer was used for the characterization of the optimized formulation, providing a FLX-EFNE with a globule size of 199 nm. For the in vivo study, a wound was induced by surgical methods, and diabetic rats (streptozotocin-induced) were divided into five groups: untreated control, vehicle-treated, FLX, FLX-EFNE, and positive control receiving a commercially available formula. The treatment continued from the day of wound induction to day 21. Then, the animals were sacrificed and skin tissues were collected at the site of wounding and used for biochemical, histopathological, immunohistochemical, and mRNA expression assessments. In the FLX-EFNE treated group, the rate of wound contraction and signs of healing were significantly higher compared to all other groups. In addition, angiogenesis, proliferation, and collagen deposition were enhanced, while oxidative stress and inflammation decreased. The present data highlight the enhanced wound healing activity of the optimized FLX-EFNE formulation.

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Section: Discussionmentioning

confidence: 99%

RETRACTED: Fluoxetine Ecofriendly Nanoemulsion Enhances Wound Healing in Diabetic Rats: In Vivo Efficacy Assessment

et al. 2022

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“…Baicalin exhibits various pharmacological activities, including anti-inflammatory, antioxidant, and anti-allergic therapies. Previous studies have demonstrated that baicalin protects against pressure stress such as that found in type-2 diabetes and cerebral ischemia injury [23][24][25][26]. Our study suggests that baicalin can reduce advanced-stage pressure ulcers by promoting wound healing related to anti-inflammatory activity.…”

Section: Discussionsupporting

confidence: 60%

Effect of Baicalin on Wound Healing in a Mouse Model of Pressure Ulcers

Kim

Ham

Jung

et al. 2022

IJMS

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One of the most frequent comorbidities that develop in chronically ill or immobilized patients is pressure ulcers, also known as bed sores. Despite ischemia-reperfusion (I/R)-induced skin lesion having been identified as a primary cause of pressure ulcers, wound management efforts have so far failed to significantly improve outcomes. Baicalin, or 5,6,7-trihydroxyflavone, is a type of flavonoid which has been shown to possess a variety of biological characteristics, including antioxidative and anti-inflammatory effects and protection of I/R injury. In vitro wound scratch assay was first used to assess the function of baicalin in wound healing. We established a mouse model of advanced stage pressure ulcers with repeated cycles of I/R pressure load. In this model, topically applied baicalin (100 mg/mL) induced a significant increase in the wound healing process measured by wound area. Histological examination of the pressure ulcer mouse model showed faster granulation tissue formation and re-epithelization in the baicalin-treated group. Next, baicalin downregulated pro-inflammatory cytokines (IL-6 and IL-1β), while upregulating the anti-inflammatory IL-10. Additionally, baicalin induced an increase in several growth factors (VEGF, FGF-2, PDGF-β, and CTGF), promoting the wound healing process. Our results suggest that baicalin could serve as a promising agent for the treatment of pressures ulcers.

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“…Diabetic food ulcer is another complication of T1DM, the pathogenesis of which is proven to be correlated with elevated NO, MDA, p-ERK and p-HSP27 while decreased level of SOD, GSH, VEGF-c, Ang-1, Tie-2, TGF-β and Smad2/3. BAI administration reversed all the alterations and eventually promote the wound healing of food ulcer (Mao et al, 2021).…”

Section: Endocrine Glandsmentioning

confidence: 92%

Scutellaria baicalensis georgi is a promising candidate for the treatment of autoimmune diseases

Wang¹,

Chen²,

Zhang

et al. 2022

Front. Pharmacol.

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Autoimmune diseases a group of disorders elicited by unexpected outcome of lymphocytes self-tolerance failure, and the common members of which include multiple sclerosis, systemic lupus erythematosus, inflammatory bowel disease, rheumatoid arthritis, and type 1 diabetes mellitus, etc. The pathogenesis of autoimmune diseases is not fully understood and the current therapeutic regimen's inefficacy in certain cases coupled with low rates of success, exorbitant financial burden, as well as numerous side effects, which do open new avenues for the role of natural products as novel therapeutic agents for auto-inflammatory disorders. Scutellaria baicalensis Georgi is a well-known and widely-recognized herbal medicine with certain ameliorative effect on diverse inflammation-involved dysfunction. Though recent advances do highlight its potential to be applied in the fight against autoimmune diseases, the specific mechanism and the related opinion on the exploring possibility are still limited which hampered the further progress. Here in this timeline review, we traced and collected the evidence of how Scutellaria baicalensis Georgi and its bioactive contents, namely baicalin, baicalein, wogonoside and wogonin affect autoimmune diseases. Moreover, we also discussed the clinical implications and therapeutic potential of Scutellaria baicalensis Georgi and its bioactive contents in autoimmune diseases treatment.

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Baicalin regulates mRNA expression of VEGF‐c, Ang‐1/Tie2, TGF‐β and Smad2/3 to inhibit wound healing in streptozotocin‐induced diabetic foot ulcer rats

Cited by 13 publications

References 19 publications

RETRACTED: Fluoxetine Ecofriendly Nanoemulsion Enhances Wound Healing in Diabetic Rats: In Vivo Efficacy Assessment

RETRACTED: Fluoxetine Ecofriendly Nanoemulsion Enhances Wound Healing in Diabetic Rats: In Vivo Efficacy Assessment

Effect of Baicalin on Wound Healing in a Mouse Model of Pressure Ulcers

Scutellaria baicalensis georgi is a promising candidate for the treatment of autoimmune diseases

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