Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice

Xing, Fei; Yi, Wenjuan; Miao, Fei; Su, Meng‐Yun; Lei, Tiechi

doi:10.3892/ijmm.2018.3391

Cited by 30 publications

(37 citation statements)

References 29 publications

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“…Baicapil is a flavonoid‐rich plant complex that promotes prolongation of the anagen phase by increasing ATP production of hair follicle cells. It also protects follicle fibroblasts from oxidative stress, helping to protect against follicular cell senescence …”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of a new formulation kit (shampoo + lotion) containing anti‐inflammatory and antioxidant agents to treat hair loss

Anzai¹,

Pereira²,

Malaquias³

et al. 2020

Dermatologic Therapy

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Androgenetic alopecia (AGA) and telogen effluvium (TE) are common causes of hair loss, with limited options for treatment. The aim of this study was to determine the efficacy and safety of a new formulation kit (Pielus Anti‐hair loss lotion and shampoo) containing anti‐inflammatory and antioxidant agents in patients with TE and/or AGA. This was a prospective, single‐arm, open‐label study with 35 women and 10 men, median age of 44 years, with clinical diagnosis of TE and/or AGA. They used the combination of shampoo and lotion daily for 90 days. There was nonoccurrence of adverse events. Phototricogram showed increase in the average number of anagen hairs at T90 (P < .001). Scalp microphotography showed increase in total follicular units, total of hairs, and median hair per follicle unit at T90. There was an increase in diameter (P = .003) and in median maximum load and resistance to traction in T90 (P = .040). Combing and washing test demonstrated a decrease in the number of shed hairs before washing (P = .005), after washing (P = .01) and in total (P < .001). The use of shampoo+ lotion daily was safe and effective to attenuate hair loss in men and women with TE and/or AGA.

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of a new formulation kit (shampoo + lotion) containing anti‐inflammatory and antioxidant agents to treat hair loss

Anzai¹,

Pereira²,

Malaquias³

et al. 2020

Dermatologic Therapy

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“…In mouse FDPC, BC stimulates the expression of Wnt3a, Wnt5a, frizzled 7, and disheveled 2, whilst inhibiting the Axin/casein kinase 1α/adenomatous polyposis coli/glycogen synthase kinase 3β degradation complex and inducing the Wnt/β-catenin-signaling activation. Moreover, BC increases the alkaline phosphatase levels in FDPC, a process associated with the activation of Wnt pathway [42]. BC is mitogenic for human FDPC, where it prevents nuclear translocation of the AR driven by DHT.…”

Section: Natural Alternative Interventionsmentioning

confidence: 98%

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Bassino

Gasparri

Munaron

2020

IJMS

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Hair loss is a disorder in which the hair falls out from skin areas such as the scalp and the body. Several studies suggest the use of herbal medicine to treat related disorders, including alopecia. Dermal microcirculation is essential for hair maintenance, and an insufficient blood supply can lead to hair follicles (HF) diseases. This work aims to provide an insight into the ethnohistorical records of some nutritional compounds containing flavonoids for their potential beneficial features in repairing or recovering from hair follicle disruption. We started from a query for “alopecia” OR “hair loss” AND “Panax ginseng C.A. Mey.“ (or other six botanicals) terms included in Pubmed and Web of Sciences articles. The activities of seven common botanicals introduced with diet (Panax ginseng C.A. Mey., Malus pumila Mill cultivar Annurca, Coffea arabica, Allium sativum L., Camellia sinensis (L.) Kuntze, Rosmarinum officinalis L., Capsicum annum L.) are discussed, which are believed to reduce the rate of hair loss or stimulate new hair growth. In this review, we pay our attention on the molecular mechanisms underlying the bioactivity of the aforementioned nutritional compounds in vivo, ex vivo and in vitro studies. There is a need for systematic evaluation of the most commonly used plants to confirm their anti-hair loss power, identify possible mechanisms of action, and recommend their best adoption.

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“…Baicalin is a glycosyloxyflavone abundantly present in many medicinal plant species. Xing et al [ 69 ] examined the hair growth promoting effect of baicalin in Balb/c-nu mice grafted with dermal and epidermal cells isolated from C57BL/6 mouse. According to this study, the mouse skin was treated two weeks post grafting with baicalin (50 or 100 µmol), a positive control drug minoxidil (100 µmol), and IWR1 (100 µmol), which is an inhibitor of β-catenin, once daily for 28 days.…”

Section: Progress In Developing Therapy For Hair Loss By Targetingmentioning

confidence: 99%

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Choi

2020

IJMS

125

105

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Persistent hair loss is a major cause of psychological distress and compromised quality of life in millions of people worldwide. Remarkable progress has been made in understanding the molecular basis of hair loss and identifying valid intracellular targets for designing effective therapies for hair loss treatment. Whereas a variety of growth factors and signaling pathways have been implicated in hair cycling process, the activation of Wnt/β-catenin signaling plays a central role in hair follicle regeneration. Several plant-derived chemicals have been reported to promote hair growth by activating Wnt/β-catenin signaling in various in vitro and in vivo studies. This mini-review sheds light on the role of Wnt/β-catenin in promoting hair growth and the current progress in designing hair loss therapies by targeting this signaling pathway.

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Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice

Cited by 30 publications

References 29 publications

Efficacy and safety of a new formulation kit (shampoo + lotion) containing anti‐inflammatory and antioxidant agents to treat hair loss

Efficacy and safety of a new formulation kit (shampoo + lotion) containing anti‐inflammatory and antioxidant agents to treat hair loss

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

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