Efficacy and safety of a new formulation kit (shampoo + lotion) containing anti‐inflammatory and antioxidant agents to treat hair loss

Abstract

Androgenetic alopecia (AGA) and telogen effluvium (TE) are common causes of hair loss, with limited options for treatment. The aim of this study was to determine the efficacy and safety of a new formulation kit (Pielus Anti‐hair loss lotion and shampoo) containing anti‐inflammatory and antioxidant agents in patients with TE and/or AGA. This was a prospective, single‐arm, open‐label study with 35 women and 10 men, median age of 44 years, with clinical diagnosis of TE and/or AGA. They used the combination of shampoo and lotion daily for 90 days. There was nonoccurrence of adverse events. Phototricogram showed increase in the average number of anagen hairs at T90 (P < .001). Scalp microphotography showed increase in total follicular units, total of hairs, and median hair per follicle unit at T90. There was an increase in diameter (P = .003) and in median maximum load and resistance to traction in T90 (P = .040). Combing and washing test demonstrated a decrease in the number of shed hairs before washing (P = .005), after washing (P = .01) and in total (P < .001). The use of shampoo+ lotion daily was safe and effective to attenuate hair loss in men and women with TE and/or AGA.

Assessment of the effects of a hair lotion in women with acute telogen effluvium: a randomized controlled study

“…26,30,31 Other commercially available lotions or shampoos with novel formulations have been found to be effective at reducing hair loss during clinical investigations. 27,29 Overall, these studies support the development of easy-to-use hair cosmetics for reducing hair loss and improving hair characteristics and appearance.…”

“…Several topical preparations, based on combination of modern and traditional medicines, have been shown to provide clinical benefits against hair loss in subjects with non‐cicatricial alopecia and to improve the overall appearance of the hair in treated subjects 26,30,31 . Other commercially available lotions or shampoos with novel formulations have been found to be effective at reducing hair loss during clinical investigations 27,29 . Overall, these studies support the development of easy‐to‐use hair cosmetics for reducing hair loss and improving hair characteristics and appearance.…”

“…The therapeutic options for treating alopecia are scarce, 7 and available drugs such as minoxidil 17,18 or finasteride 19,20 are not specifically indicated for telogen effluvium (off-label use) and can cause severe side-effects. Alternatives such as herbal medicines, [21][22][23] nutritional supplements 24,25 and topical products [26][27][28][29][30][31] have been found to enhance hair growth and health in some studies. Several topical preparations, based on combination of modern and traditional medicines, have been shown to provide clinical benefits against hair loss in subjects with non-cicatricial alopecia and to improve the overall appearance of the hair in treated subjects.…”

Reduction of telogen rate and increase of hair density in androgenetic alopecia by a cosmetic product: Results of a randomized, prospective, vehicle‐controlled double‐blind study in men

“…For polyphenols and caffeine anti-inflammatory effects have been described. 21,22,26 Besides topical minoxidil and oral finasteride drug therapy of AGA 6 autologous biotechnologies represented by PRP and Human Follicle Stem Cells (HFSCs) as well as Low-Level Light therapy (LLLT) and microneedling have recently been in the focus of investigation for their potential to maintain improved hair growth instead of requiring permanent therapy. Their modes of action have been investigated, 32,33 revealing similarities between wound healing and hair growth stimulation.…”

“…For the other ingredients present in verum, but not in vehicle (Table 1) no irritation potential is to be expected at their respective concentration in the formulations. For polyphenols and caffeine anti‐inflammatory effects have been described 21,22,26 …”