Baicalin attenuates angiotensin II-induced endothelial dysfunction

Wei, Xiling; Zhu, Xingyu; Hu, Nan; Zhang, Xiuqin; Sun, Tianjiao; Xu, Jiyang; Bian, Xiaohong

doi:10.1016/j.bbrc.2015.07.138

Cited by 37 publications

(26 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has various pharmacological actions, including antiviral, antioxidative, antitumor, antiapoptosis, and antihypertensive effects. Wei et al reported that baicalin significantly attenuated angiotensin II – induced endothelial dysfunction and oxidative stress [18]. Liu et al investigated acute myocardial infarction in rats pretreated with different concentrations of baicalin and found that baicalin significantly reduced the infarct size and levels of myocardial enzymes [creatine kinase (CK), CK-MB, lactate dehydrogenase, and cardiac troponin T], suppressed the activity and protein expression of caspase-3, and mediated mitogen-activated protein kinase cascades, suggesting that baicalin could be a promising cardioprotective agent for treating acute myocardial infarction [19].…”

Section: Discussionmentioning

confidence: 99%

Effects of Baicalin on Blood Pressure and Left Ventricular Remodeling in Rats with Renovascular Hypertension

et al. 2017

View full text Add to dashboard Cite

BackgroundThis study aimed to explore the effect of baicalin, which is a kind of bioactive flavonoid, on blood pressure and left ventricular remodeling in rats with renovascular hypertension.Material/MethodsA total of 40 male Wistar rats were randomly assigned into sham-operation (n=10) and renal hypertension model groups (2-kidney-1 clip; 2K-1C, n=30). The rats in the renal hypertension model group were randomly subdivided into 2K-1C (n=13) and 2K-1C/Baicalin groups (n=14). The cardiac function indexes were determined after 4 weeks. The morphological changes in the myocardial tissue were observed using hematoxylin and eosin and Masson staining. The myocardial apoptosis was detected using the terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling method, and the expression of C/EBP homologous protein and caspase-3 was monitored by Western blot. The expression of GRP78 and GRP94 in myocardial cells of rats was detected by qPCR and Western blot technology.ResultsNo significant change in blood pressure was observed in the 2K-1C/Baicalin group compared with the 2K-1C group, but the indexes of left ventricular remodeling significantly improved. Pathological myocardial fibrosis and expression of fibrosis-related factors significantly decreased in the 2K-1C/Baicalin group compared with the 2K-1C group. The expression of glucose-regulated protein (GRP)78, GRP94, CHOP, and caspase-3, and apoptosis of cardiomyocytes also decreased in the 2K-1C/Baicalin group.ConclusionsBaicalin has no significant antihypertensive effect, but reduced pathological changes in the myocardium, alleviated endoplasmic reticulum stress, and reduced myocardial apoptosis, reverting left ventricular remodeling in rats with renovascular hypertension.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Baicalin on Blood Pressure and Left Ventricular Remodeling in Rats with Renovascular Hypertension

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The PI3K/AKT signaling pathway mediates the eNOS activity by stimulating phosphorylation of Ser1177 residue [34], thus modulating the production of NO and subsequent endothelial-mediated vascular relaxation. Wei et al [35] found that baicalin exerted its antioxidative effect partly through the upregulation of the PI3K/AKT/eNOS pathway, suggesting that this signaling pathway may take part in the mechanisms of the protective effects induced by baicalin.…”

Section: The Role Of Each Specific Pathway Associated With Oxidatimentioning

confidence: 99%

Research Progress on Signaling Pathway‐Associated Oxidative Stress in Endothelial Cells

Liang

Lin

et al. 2017

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Studying the mechanisms of oxidative stress in endothelial cells is vital to the discovery of novel drugs for the treatment of cardiovascular disease. This article reviews the progress within the field of the role of oxidative responses in the physiology and growth of endothelial cells and emphasizes the effects of several main signal pathways involved in the oxidative stress of endothelial cells. Herein, we aim to provide scientific direction that can serve as a basis for researchers specializing in the signaling pathway of oxidative stress.

show abstract

“…Previous in vitro and in vivo studies clearly demonstrated the beneficial effects of BCN in different models of oxidative/nitrosative stress and inflammation. BCN reduced the generation of ROS, RNS and inflammatory cytokines, inhibited membrane lipid peroxidation and attenuated tissue necrosis and apoptosis (Xu et al ., ; Lin et al ., ; Zheng et al ., ; Wei et al ., ). A recent in vitro study showed that BCN significantly decreased sertoli cells apoptosis induced by heat stress (Guo et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Dose-dependent protective effect of baicalin against testicular torsion-detorsion in rats

2016

View full text Add to dashboard Cite

Testicular torsion/detorsion induces oxidative/nitrosative stress, inflammation and apoptosis of testicular tissues. Baicalin exerts antioxidant and anti-inflammatory properties. This study investigated the possible protective effect of baicalin against testicular torsion-detorsion injury in rats. Surgical testicular torsion was induced for 2 h, followed by detorsion which was continued for 24 h. Baicalin was administered in three different doses (25, 50 and 100 mg kg , by intraperitoneal injection). Each dose was given twice, the first 30 min before and the second 12 h after testicular detorsion. Baicalin, in a dose-dependent manner, decreased the torsion/detorsion-induced elevations of testicular malondialdehyde, nitric oxide, tumour necrosis factor-α, BCL2-associated X protein (Bax), cytosolic cytochrome c and caspase-3 and caspase-9 activities. Baicalin, dose dependently, attenuated the reductions of B-cell leucemia/lymphoma 2 (Bcl-2), and glutathione peroxidase and superoxide dismutase activities in testicular tissues resulted from torsion/detorsion. In addition, baicalin ameliorated the histopathological testicular tissue damage and reduced the expression of Fas ligand in rat testes exposed to torsion/detorsion in a dose-dependent manner. It was concluded that baicalin, dose dependently, ameliorated testicular injury induced by torsion/detorsion via its antioxidant, antinitrosative, anti-inflammatory and anti-apoptotic effects.

show abstract

Baicalin attenuates angiotensin II-induced endothelial dysfunction

Cited by 37 publications

References 30 publications

Effects of Baicalin on Blood Pressure and Left Ventricular Remodeling in Rats with Renovascular Hypertension

Effects of Baicalin on Blood Pressure and Left Ventricular Remodeling in Rats with Renovascular Hypertension

Research Progress on Signaling Pathway‐Associated Oxidative Stress in Endothelial Cells

Dose-dependent protective effect of baicalin against testicular torsion-detorsion in rats

Contact Info

Product

Resources

About