Research Progress on Signaling Pathway‐Associated Oxidative Stress in Endothelial Cells

Liang, Ying; Li, Jiajia; Lin, Qinlu; Huang, Ping; Zhang, Lin; Wu, Wei; Ma, You-Chu

doi:10.1155/2017/7156941

Cited by 40 publications

(39 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Keap1-Nrf2-antioxidant response element (ARE) signaling pathway is an oxidative stress-sensitive defensive response system [42,43]. Upon exposure to adverse environmental pressure, including many exogenous chemicals, the transcription factor Nrf2 escapes inhibition by the specific repressor Keap1 in the cytoplasm and associates with AREs in the nucleus where it activates the expression of multiple antioxidant enzymes and cytoprotective proteins that contribute to the defense against oxidative stress and alleviate cell damage [6,44].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Low Molecular Weight Peptides from Solenocera crassicornis Head against Cyclophosphamide-Induced Nephrotoxicity in Mice via the Keap1/Nrf2 Pathway

et al. 2020

View full text Add to dashboard Cite

The major component of the Solenocera crassicornis head protein hydrolysates-fraction 1 (SCHPs-F1) are low molecular weight peptides (MW < 1 kDa). In this study, we investigated the potential renoprotective effects of SCHPs-F1 in a cyclophosphamide (CTX) toxicity mouse model. In brief, 40 male mice were randomly divided into 5 groups and received either saline or 80 mg/kg body weight (BW) CTX by intraperitoneal injection for 5 days, followed by either saline or SCHPs-F1 (100, 200, and 400 mg/kg BW) by intragastric administration for 15 days. SCHPs-F1 treatment significantly reversed the CTX-induced decreases in the levels of blood urea nitrogen (BUN), creatinine (CRE), and cytochrome P450 (CYP450), as well as the renal histological lesions. Furthermore, the results indicated that SCHPs-F1 potentially alleviated CTX-induced nephrotoxicity through mitigating inflammatory responses, oxidative stress, and apoptosis status of the kidneys, as evidenced by decreased levels of malondialdehyde (MDA), interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ and increased levels of total antioxidant capacity (T-AOC), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Moreover, overexpression of pro-apoptotic proteins pair B-cell lymphoma-2 (Bcl-2)-associated X (Bax)/Bcl-2, cysteinyl aspartate specific proteinase (caspase)-3 and caspase-9 in renal tissues were suppressed by treatment with SCHPs-F1. In addition, the protein levels of the antioxidant factor nuclear factor erythroid-2 related factor 2 (Nrf2) and the expression levels of its downstream target genes heme-oxygenase (HO-1), glutamate-cysteine ligase modifier subunit (GCLM) and NAD(P)H dehydrogenase (quinone) 1 (NQO-1) were stimulated by treatment with SCHPs-F1 in the CTX-induced renal injury model. Taken together, our data suggested that SCHPs-F1 could provide a novel potential strategy in mitigating the nephrotoxicity caused by CTX.

show abstract

Section: Discussionmentioning

confidence: 99%

Protective Effect of Low Molecular Weight Peptides from Solenocera crassicornis Head against Cyclophosphamide-Induced Nephrotoxicity in Mice via the Keap1/Nrf2 Pathway

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Isoquercitrin is a glycated flavonoid [ 55 ] with a strong antioxidant activity due to its capacity to scavenge free radicals [ 56 ] and to inhibit arginase, favouring NO production [ 57 ]. This phenolic compound has anticancer [ 58 ] and antiapoptotic effects [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Analysis of Anti‐Inflammatory and Antioxidant Effects of Mahonia aquifolium Flower and Fruit Extracts

Andreicut

Pârvu

Moţ

et al. 2018

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Oxidative stress and inflammation are interlinked processes. The aim of the study was to perform a phytochemical analysis and to evaluate the antioxidant and anti-inflammatory activities of ethanolic Mahonia aquifolium flower (MF), green fruit (MGF), and ripe fruit (MRF) extracts. Plant extract chemical composition was evaluated by HLPC. A DPPH test was used for the in vitro antioxidant activity. The in vivo antioxidant effects and the anti-inflammatory potential were tested on a rat turpentine oil-induced inflammation, by measuring serum nitric oxide (NOx) and TNF-alpha, total oxidative status (TOS), total antioxidant reactivity (TAR), oxidative stress index (OSI), 3-nitrothyrosine (3NT), malondialdehyde (MDA), and total thiols (SH). Extracts were administrated orally in three dilutions (100%, 50%, and 25%) for seven days prior to inflammation. The effects were compared to diclofenac. The HPLC polyphenol and alkaloid analysis revealed chlorogenic acid as the most abundant compound. All extracts had a good in vitro antioxidant activity, decreased NOx, TOS, and 3NT, and increased SH. TNF-alpha was reduced, and TAR increased only by MF and MGF. MDA was not influenced. Our findings suggest that M. aquifolium has anti-inflammatory and antioxidant effects that support the use in primary prevention of the inflammatory processes.

show abstract

“…Nuclear factor erythroid 2-related factor 2 (Nrf2) is a central element of antioxidant regulation in cellular systems and its activation is mediated by OS [6]. When cellular defense capacities are exceeded by insults and the OS cannot be mediated, it is highly probable that pathologies will be generated, such as heart diseases [7], cancer [8], neurodegenerative diseases [9], or accelerated aging [10]. Physical exercise has been demonstrated to activate Nrf2 in response to the increase of ROS, a product of the energy metabolism, including the antioxidant protector response [11].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise

et al. 2019

View full text Add to dashboard Cite

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a powerful nuclear transcription factor that coordinates an antioxidant cytoprotector system complex stimulated by the increase in inoxidative stress (OS). In the present manuscript, we conduct a review on the evidence that shows the effect different modalities of physical exercise exert on the antioxidant metabolic response directed by Nrf2. During physical exercise, the reactive oxygen species (ROS) are increased; therefore, if the endogenous and exogenous antioxidant defenses are unable to control the elevation of ROS, the resulting OS triggers the activation of the transcriptional factor Nrf2 to induce the antioxidant response. On a molecular basis related to physical exercise, hormesis maintenance (exercise preconditioning) and adaptative changes in training are supported by a growing body of evidence, which is important for detailing the health benefits that involve greater resistance to environmental aggressions, better tolerance to constant changes, and increasing the regenerative capacity of the cells in such a way that it may be used as a tool to support the prevention or treatment of diseases. This may have clinical implications for future investigations regarding physical exercise in terms of understanding adaptations in high-performance athletes but also as a therapeutic model in several diseases.

show abstract

Research Progress on Signaling Pathway‐Associated Oxidative Stress in Endothelial Cells

Cited by 40 publications

References 53 publications

Protective Effect of Low Molecular Weight Peptides from Solenocera crassicornis Head against Cyclophosphamide-Induced Nephrotoxicity in Mice via the Keap1/Nrf2 Pathway

Protective Effect of Low Molecular Weight Peptides from Solenocera crassicornis Head against Cyclophosphamide-Induced Nephrotoxicity in Mice via the Keap1/Nrf2 Pathway

Phytochemical Analysis of Anti‐Inflammatory and Antioxidant Effects of Mahonia aquifolium Flower and Fruit Extracts

Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise

Contact Info

Product

Resources

About