Effects of Baicalin on Blood Pressure and Left Ventricular Remodeling in Rats with Renovascular Hypertension

Abstract

BackgroundThis study aimed to explore the effect of baicalin, which is a kind of bioactive flavonoid, on blood pressure and left ventricular remodeling in rats with renovascular hypertension.Material/MethodsA total of 40 male Wistar rats were randomly assigned into sham-operation (n=10) and renal hypertension model groups (2-kidney-1 clip; 2K-1C, n=30). The rats in the renal hypertension model group were randomly subdivided into 2K-1C (n=13) and 2K-1C/Baicalin groups (n=14). The cardiac function indexes were determined after 4 weeks. The morphological changes in the myocardial tissue were observed using hematoxylin and eosin and Masson staining. The myocardial apoptosis was detected using the terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling method, and the expression of C/EBP homologous protein and caspase-3 was monitored by Western blot. The expression of GRP78 and GRP94 in myocardial cells of rats was detected by qPCR and Western blot technology.ResultsNo significant change in blood pressure was observed in the 2K-1C/Baicalin group compared with the 2K-1C group, but the indexes of left ventricular remodeling significantly improved. Pathological myocardial fibrosis and expression of fibrosis-related factors significantly decreased in the 2K-1C/Baicalin group compared with the 2K-1C group. The expression of glucose-regulated protein (GRP)78, GRP94, CHOP, and caspase-3, and apoptosis of cardiomyocytes also decreased in the 2K-1C/Baicalin group.ConclusionsBaicalin has no significant antihypertensive effect, but reduced pathological changes in the myocardium, alleviated endoplasmic reticulum stress, and reduced myocardial apoptosis, reverting left ventricular remodeling in rats with renovascular hypertension.

Baicalin attenuated substantia nigra neuronal apoptosis in Parkinson's disease rats via the mTOR/AKT/GSK-3β pathway

“…BAI, along with its metabolite baicalein have many targets and may have protective effects on diverse diseases. The previous studies found that BAI had effects on neuroprotective, renovascular hypertension, cancer, obesity, and liver dysfunction (Dai et al, 2017;Sowndhararajan et al, 2018;Tang et al, 2016;Xi et al, 2015). However, it has been unclear that the effects and mechanisms of BAI on PD treatment.…”

Icariside II prevents hypertensive heart disease by alleviating endoplasmic reticulum stress via the PERK/ATF-4/CHOP signalling pathway in spontaneously hypertensive rats

“…Hypertensive heart disease is one of the most common complications and can lead to death in hypertensive patients. Therefore, it is an important strategy to improve ventricular remodelling and to prevent hypertensive heart disease for the reduction of the morbidity and mortality of hypertensive patients …”

“…Therefore, it is an important strategy to improve ventricular remodelling and to prevent hypertensive heart disease for the reduction of the morbidity and mortality of hypertensive patients. [19,20] In this study, we examined the function of left ventricular at the 18, 22 and 26 weeks of age in SHRs. The results showed that the LVPW became thickened with age in the SHR group, while the EF and FS decreased, indicating that SHRs exhibited ventricular remodelling and dysfunction.…”

In vitro and in vivo activities of flavonoids – apigenin, baicalin, chrysin, scutellarin – in regulation of hypertension – a review for their possible effects in pregnancy-induced hypertension

“…Baicalin has been widely studied in several in vitro and in vivo models and showed many activities such as: anti-viral [42], anti-oxidative via several pathways [43], neuroprotective and enhancin cognitive functions [44,45], anti-inflammatory [46], anti-cancer [47,48], and hepatoprotection [49]. In recent years, many studies showed anti-hypertensive properties of baicalin [46,[50][51][52][53][54][55][56][57][58][59][60], and also cardioprotective [50], antiplatelet, anticoagulant, and profibrinolytic activities [61].…”

“…On the other hand, studies in rats with renovascular hypertension showed that baicalin (2 ml of 100 mg/kg baicalin i.p. for 4 weeks once a day) has no significant antihypertensive effect [52]. Baicalein (aglycon of baicalin) protected against hypertension associated with diabetes and showed decrease of vascular deleterious effects associated with both insulin deficiency (ID) and insulin resistance (IR) models.…”