Bacupari peel extracts (Garcinia brasiliensis) reduces the biometry, lipogenesis and hepatic steatosis in obese rats

Moreira, Maria Eliza de Castro; Araújo, Fernanda de Oliveira; Sousa, Andressa Rodrigues de; Toledo, Renata Celi Lopes; Benjamin, Laércio dos Anjos; Veloso, Márcia Paranho; Reis, Kassius de Souza; Santos, Marcelo H. dos; Martino, Hércia Stampini Duarte

doi:10.1016/j.foodres.2018.08.004

Cited by 9 publications

(4 citation statements)

References 30 publications

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“…The combination of morelloflavone and 7-epiclusianone at a dose of 10.76 mg/rat and 42 mg/rat, respectively, from G. brasiliensis ethanol extract reduced body weight and liver weight compared to control high-fat diet [42]. Morelloflavone and 7-epiclusianone in the peel extract increased β-oxidation and decreased fatty acid synthesis to decrease steatosis and liver damage [42]. Morelloflavone counteracted restenosis by blocking injury-induced neointimal hyperplasia through the inhibition of vascular smooth muscle cell migration [43].…”

Section: Discussionmentioning

confidence: 93%

“…Further, morelloflavone isolated from G. dulcis fruits has diuretic and hypotensive effects [41]. The combination of morelloflavone and 7-epiclusianone at a dose of 10.76 mg/rat and 42 mg/rat, respectively, from G. brasiliensis ethanol extract reduced body weight and liver weight compared to control high-fat diet [42]. Morelloflavone and 7-epiclusianone in the peel extract increased β-oxidation and decreased fatty acid synthesis to decrease steatosis and liver damage [42].…”

Section: Discussionmentioning

confidence: 99%

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Physiological and Metabolic Effects of Yellow Mangosteen (Garcinia dulcis) Rind in Rats with Diet-Induced Metabolic Syndrome

John

Mouatt

Majzoub

et al. 2019

IJMS

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Metabolic syndrome is a cluster of disorders that increase the risk of cardiovascular disease and diabetes. This study has investigated the responses to rind of yellow mangosteen (Garcinia dulcis), usually discarded as waste, in a rat model of human metabolic syndrome. The rind contains higher concentrations of phytochemicals (such as garcinol, morelloflavone and citric acid) than the pulp. Male Wistar rats aged 8–9 weeks were fed either corn starch diet or high-carbohydrate, high-fat diet for 16 weeks, which were supplemented with 5% freeze-dried G. dulcis fruit rind powder during the last 8 weeks. We characterised metabolic, cardiovascular, liver and gut microbiota parameters. High-carbohydrate, high-fat diet-fed rats developed abdominal obesity, hypertension, increased left ventricular diastolic stiffness, decreased glucose tolerance, fatty liver and reduced Bacteroidia with increased Clostridia in the colonic microbiota. G. dulcis fruit rind powder attenuated these changes, improved cardiovascular and liver structure and function, and attenuated changes in colonic microbiota. G. dulcis fruit rind powder may be effective in metabolic syndrome by appetite suppression, inhibition of inflammatory processes and increased fat metabolism, possibly related to changes in the colonic microbiota. Hence, we propose the use of G. dulcis fruit rind as a functional food to ameliorate symptoms of metabolic syndrome.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Physiological and Metabolic Effects of Yellow Mangosteen (Garcinia dulcis) Rind in Rats with Diet-Induced Metabolic Syndrome

John

Mouatt

Majzoub

et al. 2019

IJMS

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“…PPAR‐α is a nuclear hormone receptor and could regulate fatty acid oxidative metabolism by transcriptional induction of CPT1, which worked as a rate‐limiting enzyme in fatty‐acid oxidation and involved in the fatty acids transference and TG catabolism (Moreira et al ., 2018). PGC1α is a major transcriptional co‐activator in control of fatty acid oxidation, mitochondrial function and lipid metabolism (Park et al ., 2017).…”

Section: Resultsmentioning

confidence: 99%

Hypolipidemic effects of the fermented soymilk with a novel Lactiplantibacillus plantarum strain X7021 on mice via modulating lipid metabolism and gut microbiota

Jiang

Liu

Wang

et al. 2022

Int J of Food Sci Tech

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Summary The hypolipidemic effect of soymilk fermented by Lactiplantibacillus plantarum X7021, which is a novel strain isolated from the brine of stinky tofu, on high‐fat‐diet (HFD)‐induced hyperlipidemic mice was studied. The fermented soymilk could significantly inhibit 3‐hydroxy‐3‐methyl glutaryl coenzyme A reductase (HMGR) in vitro, and lower 23.8% total cholesterol, 45.5% triglyceride, and 15.4% low density lipoprotein cholesterol and increase 31.1% high density lipoprotein cholesterol in hyperlipidemic mice serum at the end of 4 w administration period. At the same time, the oxidative stress in hyperlipidemic mice was nearly alleviated to normal level. Furthermore, the bile salt hydrolase produced by the strain, the key enzymes, hormones and transcriptional regulators involved in hepatic lipids metabolism, faecal short chain fatty acids contents, and the abundance and diversity of gut microbiota in hyperlipidemic mice were analysed, verifying that the fermented soymilk ameliorated hyperlipidemia through the degradation of bile salts, modulating lipids metabolism and influencing gut microbiota. Consequently, this fermented soymilk is prospective in the functional food for the hypolipidemic application.

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“…Consequently, it leads to the development of obesity, accompanied by adipocyte hypertrophy and hyperplasia [27][28][29]. Previous studies also reported that HFD feeding was able to induce obesity in rodents within 8 weeks [30]. A positive energy balance accompanying the development of obesity contributes to stress in the cell, production of reactive oxygen species (ROS), and inflammation [7].…”

Section: Discussionmentioning

confidence: 99%

Diverse Impact of N-Acetylcysteine or Alpha-Lipoic Acid Supplementation during High-Fat Diet Regime on Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Visceral and Subcutaneous Adipose Tissue

Wołosowicz

Łukaszuk

Kasacka

et al. 2022

Cell Physiol Biochem

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Background/Aims: The high-fat diet (HFD) regime causes obesity and contributes to the development of oxidative stress in the cells by the production of reactive oxygen species and the occurrence and progress of inflammation. Despite years of studies, there is no data explaining the mechanism of action of N-acetylcysteine (NAC) or alpha-lipoic acid (ALA) on matrix metalloproteinase-2 (MMP2) and matrix metalloproteinase-9 (MMP9) in visceral and subcutaneous adipose tissue of HFD-fed rats. Our experiment aimed to evaluate for the first time the influence of chronic antioxidants administration on MMPs biology after an HFD regime as a potential therapeutic strategy for obesity-related complications prevention. Methods: Male Wistar rats were fed a standard rodent chow or an HFD with intragastric administration of NAC or ALA for ten weeks. The collected samples were subjected to pathohistological evaluation. Real-time PCR and western blot approaches were used to check whether NAC or ALA impacts MMP2/9 expression. Results: Antioxidant supplementation markedly reduced the number of circulating inflammatory cytokines, and tissue macrophage infiltration. Moreover, NAC and ALA have a divergent impact on MMP2 and MMP9 expression in different adipose tissue localization. Conclusion: Based on our results, we speculate that NAC and ALA have a prominent effect on the MMP2/9 functions under obesity conditions.

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Bacupari peel extracts (Garcinia brasiliensis) reduces the biometry, lipogenesis and hepatic steatosis in obese rats

Cited by 9 publications

References 30 publications

Physiological and Metabolic Effects of Yellow Mangosteen (Garcinia dulcis) Rind in Rats with Diet-Induced Metabolic Syndrome

Physiological and Metabolic Effects of Yellow Mangosteen (Garcinia dulcis) Rind in Rats with Diet-Induced Metabolic Syndrome

Hypolipidemic effects of the fermented soymilk with a novel Lactiplantibacillus plantarum strain X7021 on mice via modulating lipid metabolism and gut microbiota

Diverse Impact of N-Acetylcysteine or Alpha-Lipoic Acid Supplementation during High-Fat Diet Regime on Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Visceral and Subcutaneous Adipose Tissue

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