No abstract

In order to break the aging crude oil (WACO) emulsion of the offshore platform more effectively, a highly active isocyanate, polyaryl polymethylene isocyanate (PAPI), was selected to modify the pilot-scale tannic acid demulsifier. In the addition of PAPI, its molecular weight and viscosity dramatically increased, while its relative solubility, hydroxyl number, and cloud point exhibited an opposite direction, showing an increase in hydrophobicity. After adding the above modified demulsifier, a remarkably improved water removal of WACO emulsion accompanied by a notable reduction of the water content in the oil phase monitored by the Karl Fischer method was observed. Demulsification on the offshore platform demonstrated that the best water removal was achieved when the proportion of PAPI is 1.5 wt %. Its demulsification efficiency reached 95.7%, which was 25.6% higher than the 76.2% of unmodified demulsifier. In addition, a positive correlation between viscoelasticity of emulsion and demulsification performance was found by only adjusting the parameters of the rheometer. This method may be utilized to characterize the demulsification performance by any rotary rheometer. The pilot-scale demulsification experiment demonstrated that the water removal can reach 98.14 vol % and residual water content was only 0.55 vol %. These results further confirmed the excellent demulsification performance of the modified demulsifier toward the WACO emulsion in production.

No abstract

Transcription factors bind promoter or regulatory sequences of a gene to regulate its rate of transcription. However, they are also detected in anucleated platelets. The transcription factors RUNX1, GATA1, STAT3, NFκB, and PPAR have been widely reported to play key roles in the pathophysiology of platelet hyper-reactivity, thrombosis, and atherosclerosis. These non-transcriptional activities are independent of gene transcription or protein synthesis but their underlying mechanisms of action remain poorly defined. Genetic and acquired defects in these transcription factors are associated with the production of platelet microvesicles that are known to initiate and propagate coagulation and to promote thrombosis. In this review, we summarize recent developments in the study of transcription factors in platelet generation, reactivity, and production of microvesicles, with a focus on non-transcriptional activities of selected transcription factors.