Bacteriophages in Nanotechnology: History and Future

Hyman, Paul; Denyes, Jenna

doi:10.1007/978-3-319-41986-2_22

Cited by 5 publications

(5 citation statements)

References 127 publications

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“…Phage display is used in many applications to identify binding peptides to target the phages. This technique, in which a library of binding peptides is inserted into a bacteriophage for screening for the best binding peptides to a target, has been extensively reviewed elsewhere [ 65 , 66 , 67 ]. Briefly, a population of phages, modified to contain potential binding peptides fused to surface protein of the phage capsid, are exposed to a target material such as a protein or a cell, those with matching binding peptides bind, and the others are washed away.…”

Section: Genetically Engineered Phages For Eukaryotic Applicationsmentioning

confidence: 99%

“…Another method for detecting bacteria relies not on whole modified phages but rather on phage proteins that have specificity for binding to bacteria. These proteins include the receptor binding proteins (RBPs, components of tail fibers and tail spikes) as well as the cell binding domains (CBDs, also called cell-wall binding domains) of the phage endolysins [ 67 , 119 ]. Each of these binds to specific molecules on the surface of a bacterium with varying levels of specificity.…”

Section: Genetically Engineered Phages As Sensorsmentioning

confidence: 99%

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The Many Applications of Engineered Bacteriophages—An Overview

2021

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Since their independent discovery by Frederick Twort in 1915 and Felix d’Herelle in 1917, bacteriophages have captured the attention of scientists for more than a century. They are the most abundant organisms on the planet, often outnumbering their bacterial hosts by tenfold in a given environment, and they constitute a vast reservoir of unexplored genetic information. The increased prevalence of antibiotic resistant pathogens has renewed interest in the use of naturally obtained phages to combat bacterial infections, aka phage therapy. The development of tools to modify phages, genetically or chemically, combined with their structural flexibility, cargo capacity, ease of propagation, and overall safety in humans has opened the door to a myriad of applications. This review article will introduce readers to many of the varied and ingenious ways in which researchers are modifying phages to move them well beyond their innate ability to target and kill bacteria.

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Section: Genetically Engineered Phages For Eukaryotic Applicationsmentioning

confidence: 99%

Section: Genetically Engineered Phages As Sensorsmentioning

confidence: 99%

The Many Applications of Engineered Bacteriophages—An Overview

2021

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“…They can have a broad range of bacterial hosts or a narrow spectrum of activity by infecting several species only or even a single bacterial strain 183 . Whole phage particles and phage proteins are being employed in the advancing new functional nanomaterials with nanosize properties 184 . Bacteriophage-functionalized bioactive surfaces are functional substances that can be employed as antibacterial/ antifouling surfaces in biomedical uses (e.g., indwelling medical devices (implants, stents, catheters) and wound dressings) 183 .…”

Section: Phage-based Nanomaterials Strategies: An Alternative To Conv...mentioning

confidence: 99%

“…182 Whole phage particles and phage proteins are being employed in the advancing new functional nanomaterials with nanosize properties. 183 Bacteriophagefunctionalized bioactive surfaces are functional substances that can be employed as antibacterial/antifouling surfaces in biomedical uses (e.g., indwelling medical devices (implants, stents, catheters) and wound-dressings). 182 The ability to target and destroy bacteria is a key principle for employing phages in antimicrobial chemotherapy and for bacterial diagnosis.…”

Section: Detection Prevention and Treatmentmentioning

confidence: 99%

Nanoscience-Led Antimicrobial Surface Engineering to Prevent Infections

Zare

Butler

et al. 2021

ACS Appl. Nano Mater.

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One of the major complications associated with the implantation of biomedical devices regardless of their function is biomaterial associated infection. Infections are generally initiated by opportunistic bacterial colonization and biofilm development on the surface of implanted biomaterials, rendering the infection impervious to host defenses and antimicrobials. Moreover, the infection around soft tissues also has a significant role in biomaterial-associated infections. It is well documented that the nature of an implant infection is influenced by the design and composition of the implant biomaterial, host environment, clinical procedure and patient hygiene. Herein, we explore the adhesion mechanisms of bacteria to the biomaterials and review systematic antimicrobial strategies to reduce the contamination of biomaterials and underlying implant infection using Staphylococcus aureus as a model bacterial pathogen. Also, we discuss the preventive and therapeutic strategies and explain the future perspectives for the development of nanoscience-based strategies for the engineering of antimicrobial surfaces, including nanostructure surface, microbe-surface interactions, synthetic nanostructured surfaces, dynamic surfaces with antifouling agents, coated surfaces with antimicrobial properties (polymer coating, surface release active coating).

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“…However, the issue of bacterial resistance development towards phages could happen during the process of phage treatment [11][12][13][14]. Therefore, to improve phage efficiency, tolerance, and delivery, recent approaches support coupling phages with other bio-control agents such as antibiotics [15], natural products (e.g., venom, propolis, and extracted oils) [16], phage purified enzymes (e.g., lysins, endopeptidases, amidases, and transglycosylases) [17], in addition to syntactic compounds and nanoparticles [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

The Synergistic Effect of Biosynthesized Silver Nanoparticles and Phage ZCSE2 as a Novel Approach to Combat Multidrug-Resistant Salmonella enterica

et al. 2021

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The emergence and evolution of antibiotic-resistant bacteria is considered a public health concern. Salmonella is one of the most common pathogens that cause high mortality and morbidity rates in humans, animals, and poultry annually. In this work, we developed a combination of silver nanoparticles (AgNPs) with bacteriophage (phage) as an antimicrobial agent to control microbial growth. The synthesized AgNPs with propolis were characterized by testing their color change from transparent to deep brown by transmission electron microscopy (TEM) and Fourier-Transform Infrared Spectroscopy (FTIR). The phage ZCSE2 was found to be stable when combined with AgNPs. Both minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were evaluated for AgNPs, phage, and their combination. The results indicated that MIC and MBC values were equal to 23 µg/mL against Salmonella bacteria at a concentration of 107 CFU/mL. The combination of 0.4× MIC from AgNPs and phage with Multiplicity of Infection (MOI) 0.1 showed an inhibitory effect. This combination of AgNPs and phage offers a prospect of nanoparticles with significantly enhanced antibacterial properties and therapeutic performance.

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Bacteriophages in Nanotechnology: History and Future

Cited by 5 publications

References 127 publications

The Many Applications of Engineered Bacteriophages—An Overview

The Many Applications of Engineered Bacteriophages—An Overview

Nanoscience-Led Antimicrobial Surface Engineering to Prevent Infections

The Synergistic Effect of Biosynthesized Silver Nanoparticles and Phage ZCSE2 as a Novel Approach to Combat Multidrug-Resistant Salmonella enterica

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