Bacterial, viral, and fungal infection‐related risk of Parkinson's disease: Meta‐analysis of cohort and case–control studies

Wang, Hui; Xi, Liu; Tan, Chong-Tin; Zhou, Wen; Jiang, Jin; Peng, Wuxue; Mo, Lijuan; Chen, Lifen

doi:10.1002/brb3.1549

Cited by 66 publications

(71 citation statements)

References 56 publications

(101 reference statements)

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“…In that context, a recent meta-analysis that included 23 studies investigated the impact of viral, fungal, and bacterial infections in the risk of PD and found a positive association between H. pylori infection and that disease (pooled OR, 95%CI: 1.653, 1.426-1.915, P < 0.001)[ 118 ]. Furthermore, another meta-analysis which included 7 studies found that the H. pylori infection is also associated with the clinical severity of the PD, since H. pylori -positive patients presented poorer scores when undergone Unified Parkinson Disease Rating Scale (UPDRS) evaluation [mean ± SD, 95%CI: 6.83, 2.29-11.38, P = 0.003][ 119 ].…”

Section: Extragastric Manifestationsmentioning

confidence: 99%

“…Last but not least, H. pylori infection is closely related to various socioeconomic factors, including hygiene. Consequently, some of the associations between H. pylori and PD could have been correlational and not causal[ 118 , 119 ].…”

Section: Extragastric Manifestationsmentioning

confidence: 99%

“…It is known that the H. pylori infection increases the synthesis of 1-methyl-4-phenyl-1,2,36-tetrahydropyridine (MPTP)[ 118 ]. Such substance can cause dopamine depletion, as well as damage to the substantia nigra, what can lead to PD.…”

Section: Extragastric Manifestationsmentioning

confidence: 99%

“…Such substance can cause dopamine depletion, as well as damage to the substantia nigra, what can lead to PD. Concomitantly, H. pylori infection has been found to reduce levodopa absorption, what potentially has the exacerbation of PD symptoms as a consequence[ 118 ].…”

Section: Extragastric Manifestationsmentioning

confidence: 99%

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Helicobacter pylori infection: Beyond gastric manifestations

Santos

Brito

Silva

et al. 2020

WJG

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Helicobacter pylori ( H. pylori ) is a bacterium that infects more than a half of world’s population. Although it is mainly related to the development of gastroduodenal diseases, several studies have shown that such infection may also influence the development and severity of various extragastric diseases. According to the current evidence, whereas this bacterium is a risk factor for some of these manifestations, it might play a protective role in other pathological conditions. In that context, when considered the gastrointestinal tract, H. pylori positivity have been related to Inflammatory Bowel Disease, Gastroesophageal Reflux Disease, Non-Alcoholic Fatty Liver Disease, Hepatic Carcinoma, Cholelithiasis, and Cholecystitis. Moreover, lower serum levels of iron and vitamin B12 have been found in patients with H. pylori infection, leading to the emergence of anemias in a portion of them. With regards to neurological manifestations, a growing number of studies have associated that bacterium with multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, and Guillain-Barré syndrome. Interestingly, the risk of developing cardiovascular disorders, such as atherosclerosis, is also influenced by the infection. Besides that, the H. pylori -associated inflammation may also lead to increased insulin resistance, leading to a higher risk of diabetes mellitus among infected individuals. Finally, the occurrence of dermatological and ophthalmic disorders have also been related to that microorganism. In this sense, this minireview aims to gather the main studies associating H. pylori infection with extragastric conditions, and also to explore the main mechanisms that may explain the role of H. pylori in those diseases.

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Section: Extragastric Manifestationsmentioning

confidence: 99%

Section: Extragastric Manifestationsmentioning

confidence: 99%

Section: Extragastric Manifestationsmentioning

confidence: 99%

Section: Extragastric Manifestationsmentioning

confidence: 99%

See 2 more Smart Citations

Helicobacter pylori infection: Beyond gastric manifestations

Santos

Brito

Silva

et al. 2020

WJG

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“…With the acceleration of the population aging process and decrease of physical functions of senile patients, the incidence and prevalence of PD have shown an increasing trend year by year (Nussbaum and Ellis, 2003;Hirsch et al, 2016). Approximately between 4.1 million and 4.6 million people are affected by PD in 2005 totaled, and it has been estimated that number will more than double by 2030 to between 8.7 million and 9.3 million in the most populous nations (Dorsey et al, 2007;Wang et al, 2020). The majority of people who get PD are over the age of 60, the incidence of PD among people over 60 is about one percent, men are more susceptible to PD than women at a ratio of about 3:2 (De Lau and Breteler, 2006;Dorsey and Bloem, 2018;Cerri et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota Approach—A New Strategy to Treat Parkinson’s Disease

Liu

Nie

et al. 2020

Front. Cell. Infect. Microbiol.

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Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by neuronal loss and dysfunction of dopaminergic neurons located in the substantia nigra, which contain a variety of misfolded a-synuclein (a-syn). Medications that increase or substitute for dopamine can be used for the treatment of PD. Recently, numerous studies have shown gut microbiota plays a crucial role in regulating and maintaining multiple aspects of host physiology including host metabolism and neurodevelopment. In this review article, the role of gut microbiota in the etiological mechanism of PD will be reviewed. Furthermore, we discussed current pharmaceutical medicine-based methods to prevent and treat PD, followed by describing specific strains that affect the host brain function through the gut-brain axis. We explained in detail how gut microbiota directly produces neurotransmitters or regulate the host biosynthesis of neurotransmitters. The neurotransmitters secreted by the intestinal lumen bacteria may induce epithelial cells to release molecules that, in turn, can regulate neural signaling in the enteric nervous system and subsequently control brain function and behavior through the brain-gut axis. Finally, we proved that the microbial regulation of the host neuronal system. Endogenous a-syn can be transmitted long distance and bidirectional between ENS and brain through the circulatory system which gives us a new option that the possibility of altering the community of gut microbiota in completely new medication option for treating PD.

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Long-term Risk of Parkinson Disease Following Influenza and Other Infections

et al. 2021

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Influenza has been associated with the risk of developing Parkinson disease, but the association is controversial. OBJECTIVE To examine whether prior influenza and other infections are associated with Parkinson disease more than 10 years after infection. DESIGN, SETTING, AND PARTICIPANTS This case-control study used data from 1977 to 2016 from the Danish National Patient Registry. All individuals with Parkinson disease, excluding those with drug-induced parkinsonism, were included and matched to 5 population controls on sex, age, and date of Parkinson diagnosis. Data were analyzed from December 2019 to September 2021. EXPOSURES Infections were ascertained between 1977 and 2016 and categorized by time from infection to Parkinson disease diagnosis. To increase specificity of influenza diagnoses, influenza exposure was restricted to months of peak influenza activity.

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Bacterial, viral, and fungal infection‐related risk of Parkinson's disease: Meta‐analysis of cohort and case–control studies

Cited by 66 publications

References 56 publications

Helicobacter pylori infection: Beyond gastric manifestations

Helicobacter pylori infection: Beyond gastric manifestations

Gut Microbiota Approach—A New Strategy to Treat Parkinson’s Disease

Long-term Risk of Parkinson Disease Following Influenza and Other Infections

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