Bacterial translocation and barrier dysfunction enhance colonic tumorigenesis

Zhang, Yongguo; Zhang, Jilei; Xia, Yinglin; Sun, Jun

doi:10.1016/j.neo.2022.100847

Cited by 12 publications

(5 citation statements)

References 35 publications

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“…Alcian blue/periodic acid-Schiff staining was performed on paraffin sections of colon tissue fixed with Carnoy’s fixative [ 25 ]. Slides were used for counting GCs.…”

Section: Methodsmentioning

confidence: 99%

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Garrett¹,

Zhang²,

Xia³

et al. 2024

Engineering

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“…Alcian blue/periodic acid-Schiff staining was performed on paraffin sections of colon tissue fixed with Carnoy’s fixative [ 25 ]. Slides were used for counting GCs.…”

Section: Methodsmentioning

confidence: 99%

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Garrett¹,

Zhang²,

Xia³

et al. 2024

Engineering

Self Cite

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“…OMVs secreted from F. nucleatum alter epithelial home-ostasis by targeting the receptor-interacting protein kinase 1 (RIPK1)-mediated cell death pathway. This weakens the intestinal mucosal barrier and leads to ulcerative colitis [91,92].…”

Section: Cancermentioning

confidence: 99%

Gut Bacteria Provide Genetic and Molecular Reporter Systems to Identify Specific Diseases

Dicks

2024

IJMS

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With genetic information gained from next-generation sequencing (NGS) and genome-wide association studies (GWAS), it is now possible to select for genes that encode reporter molecules that may be used to detect abnormalities such as alcohol-related liver disease (ARLD), cancer, cognitive impairment, multiple sclerosis (MS), diabesity, and ischemic stroke (IS). This, however, requires a thorough understanding of the gut–brain axis (GBA), the effect diets have on the selection of gut microbiota, conditions that influence the expression of microbial genes, and human physiology. Bacterial metabolites such as short-chain fatty acids (SCFAs) play a major role in gut homeostasis, maintain intestinal epithelial cells (IECs), and regulate the immune system, neurological, and endocrine functions. Changes in butyrate levels may serve as an early warning of colon cancer. Other cancer-reporting molecules are colibactin, a genotoxin produced by polyketide synthetase-positive Escherichia coli strains, and spermine oxidase (SMO). Increased butyrate levels are also associated with inflammation and impaired cognition. Dysbiosis may lead to increased production of oxidized low-density lipoproteins (OX-LDLs), known to restrict blood vessels and cause hypertension. Sudden changes in SCFA levels may also serve as a warning of IS. Early signs of ARLD may be detected by an increase in regenerating islet-derived 3 gamma (REG3G), which is associated with changes in the secretion of mucin-2 (Muc2). Pro-inflammatory molecules such as cytokines, interferons, and TNF may serve as early reporters of MS. Other examples of microbial enzymes and metabolites that may be used as reporters in the early detection of life-threatening diseases are reviewed.

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“…In the tumor microenvironment (TME), microbes thrive due to factors like angiogenesis and immune suppression, influencing the cancer phenotype and progression [504,505]. Intratumoral bacteria, such as F. nucleatum, enhance metastatic potential and inhibit local antitumor immunity, impacting cancer prognosis [506,507].…”

Section: Gut Microbiota: a Double-edged Sword In Cancer Treatmentmentioning

confidence: 99%

Neutrophils in the Focus: Impact on Neuroimmune Dynamics and the Gut–Brain Axis

Krsek,

Baticic

2024

Gastrointestinal Disorders

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The growing field of gut–brain axis research offers significant potential to revolutionize medical practices and improve human well-being. Neutrophils have emerged as key players in gut–brain inflammation, contributing to the relocation of inflammatory cells from the gut to the brain and exacerbating neuroinflammation in conditions, such as inflammatory bowel disease and neurodegenerative diseases. The intricate network of molecular and functional connections that interlinks the brain with the gastrointestinal system is characterized by complex signaling pathways. Understanding the complex interplay among the microbiota, gut, and brain offers unparalleled opportunities to develop novel therapeutic interventions for neurological disorders and improve overall health outcomes. The aim of this review was to comprehensively summarize current knowledge and future perspectives regarding the multifaceted role of neutrophils and their impact on the neuroimmune dynamics in the context of the gut–brain axis.

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Bacterial translocation and barrier dysfunction enhance colonic tumorigenesis

Cited by 12 publications

References 35 publications

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Gut Bacteria Provide Genetic and Molecular Reporter Systems to Identify Specific Diseases

Neutrophils in the Focus: Impact on Neuroimmune Dynamics and the Gut–Brain Axis

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