Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Garrett, Shari; Zhang, Yongguo; Xia, Yinglin; Sun, Jun

doi:10.1016/j.eng.2023.06.007

Cited by 1 publication

(3 citation statements)

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“… 12 Our previous study has demonstrated that pathogenic Salmonella manipulates Axin1 signaling for its infection and invasion in vitro 13 . In our current paper 3 , we found that Axin1 knockout alleviates DSS-induced colitis via alteration of intestinal environment and microbiota. These findings imply that Axin1 could play multiple roles in different signaling pathways, such as pro-inflammation and anti-tumor responses.…”

Section: Axin1 Contributes To Intestinal Inflammation By Regulating T...mentioning

confidence: 67%

“…Garrett et al . demonstrate a novel and critical role of Axin1 in regulating intestinal epithelial development and microbial homeostasis 3 . Our study has provided insights into the molecular mechanism that might contribute to IBD.…”

Section: Future Directionsmentioning

confidence: 99%

“… 1 , 2 However, little is known regarding its specific function in host-microbial interactions. In a recent study published in Engineering 3 , Garrett et al have demonstrated a new role for intestinal epithelial Axin1 in colitis by reducing Akkermansia muciniphila (A. muciniphila) , thus making the host susceptible to colitis. Conditional deletion of Axin1 in epithelial cells and Paneth cells protects against colitis with enriched A. muciniphila in the microbiome community.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Axin1‘s mystique in manipulating microbiome amidst colitis

Garrett,

Asada,

Sun

2023

Gut Microbes

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Classically, Axin1 is considered a regulator of Wnt/β-catenin signaling. However, Axin1’s roles in host-microbial interactions have been unknown. Our recent study has demonstrated that deletion of intestinal epithelial Axin1 in epithelial cells and Paneth cells protects the host against colitis by enhancing Akkermansia muciniphila . Loss of intestinal epithelial or Paneth cell Axin1 results in increased Wnt/β-catenin signaling, proliferation, and cell migration. This is associated with morphologically altered goblet and Paneth cells, including increased Muc2 and decreased lysozyme. Axin1 deletion specifically enriched Akkermansia muciniphila . Akkermansia muciniphila in Axin1 knockout mice is the driver of protection against DSS-induced inflammation. Here, we feature several significant conceptual changes, such as differences between Axin1 and Axin2, Axin1 in innate immunity and microbial homeostasis, and Axin1 reduction of Akkermansia muciniphila . We discuss an important trend in the field related to Paneth cells and tissue-specific Axin1 manipulation of microbiome in health and inflammation.

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Section: Axin1 Contributes To Intestinal Inflammation By Regulating T...mentioning

confidence: 67%

Section: Future Directionsmentioning

confidence: 99%