Axin1‘s mystique in manipulating microbiome amidst colitis
Shari Garrett,
Monica C. Asada,
Jun Sun
Abstract:Classically, Axin1 is considered a regulator of Wnt/β-catenin signaling. However, Axin1’s roles in host-microbial interactions have been unknown. Our recent study has demonstrated that deletion of intestinal epithelial Axin1 in epithelial cells and Paneth cells protects the host against colitis by enhancing
Akkermansia muciniphila
. Loss of intestinal epithelial or Paneth cell Axin1 results in increased Wnt/β-catenin signaling, proliferation, and cell migration. This is associated with m… Show more
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