Bacterial Infections in the Early Posttransplant Period After Liver Transplantation – Etiological Agents and Their Susceptibility.

Kawecki, D.; Sawicka-Grzelak, A.; Kot, Katarzyna; Swoboda-Kopeć, Ewa; Chmura, A.; Pacholczyk, Marek; Łągiewska, B; Małkowski, Piotr; Rowińskí, W; Łuczak, M.

doi:10.1097/01.tp.0000330702.62835.ff

Cited by 28 publications

(42 citation statements)

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“…Intra-class variation of susceptibility reinforces the need for antimicrobial susceptibility testing before antimicrobial administration. While the proportion of ESBL producing coliforms is comparable, the proportion of MRSA is in contrast with data from developed countries [16][17][18][19]. Though, the pattern of isolates is comparable to other studies 3, 5, 6, 10 , resistance patterns observed may be alarming.…”

Section: T a P H Y L O C O C C U S Hemolyticuscontrasting

confidence: 51%

Bacterial infections and emerging resistance in renal transplant recipients

Khan

Sahni

2014

Bangladesh J Med Sci

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Objective: Renal transplantation is frequently complicated by bacterial infections in the scenario of immunosuppression, altered metabolism and interventions resulting in prolonged morbidity. Subdued clinical presentation, antimicrobial resistance and toxicity question the outcome of transplantation. This retrospective study conducted at tertiary care apex transplant centre highlights colonization, clinical infection and antimicrobial resistance patterns in Renal Transplant Recipients (RTR). Materials and methods: Infection and antimicrobial resistance patterns in 130 RTR were studied. Clinico-demographic and transplant parameters were noted. Infection screening in the post transplant period along with antimicrobial susceptibility were used to analyze data in a post transplant time frame. Results and discussion: Culture positivity timeline was dominated by post surgical infections in the first week post transplant. Urinary infections followed by blood stream infections were noted. Infection profile included simultaneous polymicrobial, prolonged and widespread infections. Multi-resistant organisms producing beta lactamases and extended spectrum beta lactamases were isolated. Conclusion: Transplant recipients remain prone to bacterial infections with multi-resistant organisms which may persist due to immunosuppression, altered metabolism and toxicity, and contribute to nosocomial hazard. Infection control may be targeted at avoidance of donor derived infections, surgical complications, epidemiologic exposures, strengthening antimicrobial prophylaxis and anti-infection engineering. Antimicrobial stewardship, outbreak and epidemic preparedness should be ensured. DOI: http://dx.doi.org/10.3329/bjms.v14i1.16306 Bangladesh Journal of Medical Science Vol.14(1) 2015 p.14-21

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Section: T a P H Y L O C O C C U S Hemolyticuscontrasting

confidence: 51%

Bacterial infections and emerging resistance in renal transplant recipients

Khan

Sahni

2014

Bangladesh J Med Sci

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“…Hepatic artery thrombosis (HAT) may be the most common pre‐disposing factor leading to abscess formation, in addition to other major contributors including hepatic artery stenosis, biliary stricture, and Roux‐en‐Y choledochojejunostomy . Donation after cardiac death and traumatized liver graft are rare but important conditions associated with hepatic abscess development …”

Section: Introductionmentioning

confidence: 99%

Hepatic abscess: a rare complication after liver transplant

Kornasiewicz

Hołówko

Grąt

et al. 2016

Clinical Transplantation

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“…However, with successful LT more than 90% of patients survive one year and 75% of them survive five years post-transplant, with most of patients having an excellent quality of life [95]. Early referral to an LT center is essential, since deterioration in a patient’s health status can occur suddenly, the chance of receiving a liver transplant increases with early placement on the waiting list, the prediction of which patients will recover spontaneously is quite difficult, and once brainstem herniation has occurred patients cannot be saved by any means, including LT [96]. …”

Section: Treatment Of Hepatic Encephalopathymentioning

confidence: 99%

Hepatic encephalopathy: An updated approach from pathogenesis to treatment

et al. 2011

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SummaryOne of the most serious complications of chronic or fulminant liver failure is hepatic encephalopathy (HE), associated most commonly with cirrhosis. In the presence of chronic liver disease, HE is a sign of decompensation, while in fulminant liver failure its development represents a worrying sign and usually indicates that transplantation will be required. Despite the significance of HE in the course of liver disease, the progress in development of new therapeutic options has been unremarkable over the last 20 years. An up-to-date review regarding HE, including both research and review articles. HE is a serious and progressive, but potentially reversible, disorder with a wide spectrum of neuropsychiatric abnormalities and motor disturbances that ranges from mild alteration of cognitive and motor function to coma and death. Although a clear pathogenesis is yet to be determined, elevated ammonia in serum and the central nervous system is the mainstay for pathogenesis and treatment of HE. Management includes early diagnosis and prompt treatment of precipitating factors. Clinical trials and extensive clinical experience have established the efficacy of diverse substances in HE treatment. Novel therapies with clinical promise include: L-ornithine L-aspartate, sodium benzoate, phenylacetate, AST-120, and the molecular adsorbent recirculating system. Eventually, liver transplantation is often the most successful long-term therapy for HE.

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Bacterial Infections in the Early Posttransplant Period After Liver Transplantation – Etiological Agents and Their Susceptibility.

Cited by 28 publications

References 0 publications

Bacterial infections and emerging resistance in renal transplant recipients

Bacterial infections and emerging resistance in renal transplant recipients

Hepatic abscess: a rare complication after liver transplant

Hepatic encephalopathy: An updated approach from pathogenesis to treatment

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