Bacterial infection profile and predictors among patients admitted to a burn care center: A retrospective study

Bourgi, Joseph; Said, J M; Yaakoub, Celestie; Atallah, Bachir; Al-Akkary, Nancy; Sleiman, Ziad; Ghanimé, G

doi:10.1016/j.burns.2020.05.004

Cited by 23 publications

(18 citation statements)

References 37 publications

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“…In line with several other studies ( Vickers et al., 2019 ; Bourgi et al., 2020 ; Emami et al., 2020 ), A. baumannii , P. aeruginosa , and K. pneumoniae are the predominant Gram-negative bacteria in BICU and BCW. Overall, the resistant rate of A. baumannii and K. pneumoniae gradually increased in BICU and BCW although the resistance rate of P. aeruginosa decreased in BICU and stayed low in BCW in accordance with all of China ( Hu et al., 2018 ).…”

Section: Discussionsupporting

confidence: 90%

“…In comparing the current results with our preliminary study ( Yali et al., 2014 ), Gram-negative bacteria is still the main pathogen in BICU and BCW, which is also similar to studies in Southeast China ( Li et al., 2018 ), Iran ( Emami et al., 2020 ), Morocco ( Frikh et al., 2018 ), and Lebanon ( Bourgi et al., 2020 ). However, the ranks of the main pathogens have changed.…”

Section: Discussionsupporting

confidence: 89%

“…In the absence of more effective methods, hand hygiene, use of personal protective equipment, contact isolation, negative-pressure patient rooms, frequent room cleaning, and daily evaluation of invasive lines and devices are necessary to reduce the risk of hospital infection (Tejiram and Shupp, 2020). In line with several other studies (Vickers et al, 2019;Bourgi et al, 2020;Emami et al, 2020), A. baumannii, P. aeruginosa, and K. pneumoniae are the predominant Gram-negative bacteria in BICU and BCW. Overall, the resistant rate of A. baumannii and K. pneumoniae gradually increased in BICU and BCW although the resistance rate of P. aeruginosa decreased in BICU and stayed low in BCW in accordance with all of China (Hu et al, 2018).…”

Section: Fungimentioning

confidence: 82%

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Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common Wards

Gong

Peng

Luo

et al. 2021

Front. Cell. Infect. Microbiol.

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Infection is the leading cause of complications and deaths after burns. However, the difference in infection patterns between the burn intensive care unit (BICU) and burn common wards (BCW) have not been clearly investigated. The present study aimed to compare the infection profile, antimicrobial resistance, and their changing patterns in burn patients in BICU and BCW. Clinical samples were analyzed between January 1, 2011, and December 31, 2019, in the Institute of Burn Research in Southwest China. The patient information, pathogen distribution, sources, and antimicrobial resistance were retrospectively collected. A total of 3457 and 4219 strains were detected in BICU and BCW, respectively. Wound secretions accounted for 86.6% and 44.9% in BCW and BICU, respectively. Compared with samples in BCW, samples in BICU had more fungi (11.8% vs. 8.1%), more Gram-negative bacteria (60.0% vs. 50.8%), and less Gram-positive bacteria (28.2% vs. 41.1%). Acinetobacter baumannii were the most common pathogen in BICU, compared with Staphylococcus aureus in BCW. S. aureus was the most frequent pathogen in wound secretions and tissues from both BICU and BCW. However, A. baumannii were the first in blood, sputum, and catheter samples from BICU. Overall, the multidrug-resistance (MDR) rate was higher in BICU than in BCW. However, the gap between BICU and BCW gradually shortened from 2011 to 2019. The prevalence of MDR A. baumannii and Klebsiella pneumonia significantly increased, especially in BCW. Furthermore, Carbapenem resistance among K. pneumoniae significantly increased in BICU (4.5% in 2011 vs. 40% in 2019) and BCW (0 in 2011 vs. 40% in 2019). However, the percentage of MDR P. aeruginosa sharply dropped from 85.7% to 24.5% in BICU. The incidence of MRSA was significantly higher in BICU than in BCW (94.2% vs. 71.0%) and stayed at a high level in BICU (89.5% to 96.3%). C. tropicalis and C. albicans were the two most frequent fungi. No resistance to Amphotericin B was detected. Our study shows that the infection profile is different between BICU and BCW, and multidrug resistance is more serious in BICU than BCW. Therefore, different infection-control strategies should be emphasized in different burn populations.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Section: Fungimentioning

confidence: 82%

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Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common Wards

Gong

Peng

Luo

et al. 2021

Front. Cell. Infect. Microbiol.

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“… 34 Tsao LH reported the risk of CRPA infection increases 1% with each hospitalization day, 35 which was in line with another independent risk factor LOS > 14 days. 36 – 37 With the extension of hospital stay, they were more likely to infect P. aeruginosa , including endogenous infection by colonization in nasopharynx, respiratory tract, skin and intestinal tract, and exogenous infection by the prolonged survival of P. aeruginosa in hospital surroundings. 36 …”

Section: Discussionmentioning

confidence: 99%

Carbapenem Resistant Pseudomonas aeruginosa Infections in Elderly Patients: Antimicrobial Resistance Profiles, Risk Factors and Impact on Clinical Outcomes

Qin¹,

Zou²,

Tao³

et al. 2022

IDR

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“…However, the necrotic tissue in the wound bed represents an excellent growth medium for microorganisms, especially for bacteria with a short generation time. Burn wound infections are relatively diverse, ranging from cellulitis and impetigo to invasive wound infections requiring prompt antimicrobial treatment with early debridement [ 8 ]. In our patient, we used manual debridement with the removal of larvae and antiseptic treatment.…”

Section: Review and Discussionmentioning

confidence: 99%

Human Infections by Wohlfahrtiimonas chitiniclastica: A Mini-Review and the First Report of a Burn Wound Infection after Accidental Myiasis in Central Europe

et al. 2021

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Wohlfahrtiimonas chitiniclastica are bacteria that cause rare infections, typically associated with the infestation of an open wound with fly larvae. Here, we present a unique case report of the first W. chitiniclastica isolation from a burn wound with accidental myiasis in a 63-year-old homeless man and a literature review focused on human infections caused by these bacteria. So far, 23 cases of infection with W. chitiniclastica have been reported; in 52% of these, larvae were found in the wound area. Most of these cases suffered from chronic non-healing wound infections but none of these were burn injuries. The overall fatality rate associated directly with W. chitiniclastica in these cases was 17%. Infections with parasitic larvae occur in moderate climates (especially in people living in poor conditions); therefore, an infection with rare bacteria associated with accidental myiasis, such as W. chitiniclastica, can be expected to become more common there. Thus, in view of the absence of recommendations regarding the treatment of patients with accidental myiasis and, therefore, the risk of infection with W. chitiniclastica or other rare pathogens, we provide a list of recommendations for the treatment of such patients. The importance of meticulous microbial surveillance using molecular biological methods to facilitate the detection of rare pathogens is emphasized.

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Bacterial infection profile and predictors among patients admitted to a burn care center: A retrospective study

Cited by 23 publications

References 37 publications

Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common Wards

Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common Wards

Carbapenem Resistant Pseudomonas aeruginosa Infections in Elderly Patients: Antimicrobial Resistance Profiles, Risk Factors and Impact on Clinical Outcomes

Human Infections by Wohlfahrtiimonas chitiniclastica: A Mini-Review and the First Report of a Burn Wound Infection after Accidental Myiasis in Central Europe

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